Isolated Optic Nerve Metastasis of Breast Cancer Initially Mimicking Retrobulbar Optic Neuritis

Cho, Hyun Kyung; Park, Shin Hae; Shin, Sun Young

doi:10.5301/ejo.2010.6099

Cited by 11 publications

(10 citation statements)

References 6 publications

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“…MRI findings include optic nerve enlargement that is diffuse (more common) or in a circumscribed area, associated exudates or hemorrhage, and optic canal involvement in osteophilic metastatic tumors such as prostate carcinoma. 10,11,16,17,18,19 Our patient had normal orbital and brain MRI.…”

Section: Discussionmentioning

confidence: 58%

Isolated Unilateral Infiltrative Optic Neuropathy in a Patient with Breast Cancer

Aghdam

Zand

Sanjari

2019

tjo

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Metastasis to the optic nerve is very rare. We report a case of metastatic breast cancer to the optic nerve head without the involvement of other ocular or orbital structures. The patient, a 39-year-old female who had been previously treated for breast cancer, reported a gradually progressive decrement in visual acuity of the right eye during the past two months. Fundus examination of the affected eye revealed swelling of the optic disc which was infiltrated by a yellowish mass. Further evaluation using optical coherence tomography and fluorescein angiography showed optic disc swelling. Magnetic resonance imaging revealed no pathologic findings. With a diagnosis of unilateral infiltrative optic neuropathy, we referred the patient to an oncologist for further evaluation.

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Section: Discussionmentioning

confidence: 58%

Isolated Unilateral Infiltrative Optic Neuropathy in a Patient with Breast Cancer

Aghdam

Zand

Sanjari

2019

tjo

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“…Furthermore, the development of metastatic lesion in optic nerve sheath meningioma has also been reported [10]. The diagnosis of these lesions could be further complicated by unspecific presentation as paraneoplastic optic neurits [11] [12].…”

Section: Discussionmentioning

confidence: 99%

Microsurgical Treatment of Optic Nerve Metastasis: Case Report and Review of the Literature

Kondoff¹,

Milev²,

Tzekov³

et al. 2015

CRCM

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Metastatic lesions to the eye and optic nerve have incidence of 12% and are observed predominantly in patients, diagnosed with breast and lung cancer. However, isolated involvement of the optic nerve by breast cancer metastasis is much rarely reported with only 13 cases reported in the literature by 2013, according to Cherkaev et al., that were often preoperatively misdiagnosed. Herewith we present a rare case of optic nerve metastasis in a previously diagnosed breast cancer patient. Review of the literature was done with analysis of the diagnostic difficulties that these cases present and the role of the neurosurgeon in the management of the patients.

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“…Metastatic disease to the eye is uncommon, with an incidence ranging from 0.07% to 12 %. 1 The commonest primary tumour site was found to be breast cancer (BC). 2 Metastases from BC usually involve the uveal tract or orbital structures in these cases.…”

Section: Introductionmentioning

confidence: 99%

Central retinal vein occlusion as the initial presentation of isolated optic nerve sheath metastasis from breast cancer

Palikat

Zahari

Chung

et al. 2021

MyJO

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Background: Isolated metastasis to the optic nerve (ON) and its sheath from breast cancer (BC) without involvement of other ocular structures is extremely rare. However, it is a pivotal diagnosis to rule out as it is a both sight- and life-threatening condition. We report a case of isolated ON sheath metastasis from BC presenting with central retinal vein occlusion (CRVO). Case presentation: A 47-year-old woman with known metastatic BC presented with painless, progressive vision loss in the left eye. Visual acuity was hand movement with ipsilateral relative afferent pupillary defect. Fundal features suggested CRVO. Atypical rapid resolution of these features led to suspect ON metastasis. Magnetic resonance of the brain showed perineural enhancement of the optic nerves. Vision improved with radiotherapy. Conclusion: Isolated ON sheath metastasis from BC is rare and may present with CRVO. High degree of suspicion is warranted in patients with metastatic disease and atypical findings.

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Isolated Optic Nerve Metastasis of Breast Cancer Initially Mimicking Retrobulbar Optic Neuritis

Abstract: Patients with known cancer at another site of the body who develop optic neuropathy, with or without evidence of metastasis, should be suspected to have cancer as a cause.

Cited by 11 publications

References 6 publications

Isolated Unilateral Infiltrative Optic Neuropathy in a Patient with Breast Cancer

Isolated Unilateral Infiltrative Optic Neuropathy in a Patient with Breast Cancer

Microsurgical Treatment of Optic Nerve Metastasis: Case Report and Review of the Literature

Central retinal vein occlusion as the initial presentation of isolated optic nerve sheath metastasis from breast cancer

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