Isolated orbital mucormycosis: a rare presentation ending in a fatal outcome

Ziakas, Panayiotis D.; Adraktas, Panayiotis; Ntountas, John; Skarpidi, Eva; Filippi, Vasiliki; Kechagias, Dimitrios; Karianakis, George

doi:10.1016/j.ijid.2008.01.015

Cited by 5 publications

(2 citation statements)

References 4 publications

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“…To our knowledge, there are only 2 other published cases of mucormycosis isolated to the orbits and CNS. 6,7 Both of these cases had bilateral orbital involvement, making ours the first published case with isolated, unilateral orbitocerebral mucormycosis (Pubmed search July 10, 2018 using combinations of search terms orbito-cerebral, orbital-cerebral, and orbitocerebral with mucomycosis, mucormycosis and zygomycosis).…”

Section: Discussionmentioning

confidence: 99%

Orbitocerebral Mucormycosis in a Patient With Central Nervous System Lymphoma

Beketova

Bailey

Crowell

et al. 2018

Ophthalmic Plastic &Amp; Reconstructive Surgery

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A 61-year-old man with well-controlled diabetes mellitus type 2, cirrhosis from hepatitis C, alcohol abuse, and portal hypertension presented with painful vision loss and left orbital swelling. Imaging showed diffuse orbital, perineural, and pachymeningeal inflammation. He was initially diagnosed with neurosarcoidosis. However, cerebrospinal fluid analysis revealed central nervous system lymphoma, and lacrimal gland biopsy showed fungal organisms consistent with mucormycosis. We describe a case of Mucorales infection lacking sinonasal involvement and discuss the differential diagnosis and management of patients presenting with orbital and central nervous system inflammation from this uncommon fungal infection.

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Section: Discussionmentioning

confidence: 99%

Orbitocerebral Mucormycosis in a Patient With Central Nervous System Lymphoma

Beketova

Bailey

Crowell

et al. 2018

Ophthalmic Plastic &Amp; Reconstructive Surgery

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“…[7][8][9] Up to the present, to the best of our knowledge, only 1 case of isolated orbital mucormycosis has been reported in the English literature. 10 Though commonly reported to have a high rate of nasal involvement, the lack of strong evidence of such involvement should not delay or exclude a diagnosis of ROCM. The black eschar, which is present in 20% to 40% of patients is highly suggestive of the disease and is usually in the nasal cavity.…”

Section: Discussionmentioning

confidence: 99%

Isolated Orbito-cerebral Mucormycosis

Lau¹,

Wang²,

Yeh³

et al. 2011

The Neurologist

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Rhino-orbito-cerebral mucormycosis is a fatal infection in immunocompromised hosts. Prompt recognition of this clinical condition is essential for early diagnosis to avoid a delay of treatment. The presence of black eschar, usually in the nasal cavity, is the most alerting sign to the diagnosis. We present a patient with extremely fulminant ROCM in which the disease might be acquired via an orbital infection without nasal or paranasal involvement. With black eschars appearing at the bilateral canthi as the first alarm to extensive vascular involvement, the lethal infection rapidly evolved to occlusion of the bilateral ophthalmic arteries and eventually major intracranial arteries.

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