Isolated post-operative Aspergillus niger endophthalmitis

Kermani, N.; Aggarwal, S P

doi:10.1038/eye.2000.32

Cited by 15 publications

(6 citation statements)

References 7 publications

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“…16 Only a few studies have reported data concerning the intracameral application of amphotericin B in the management of keratomycosis, and most of them were experimental laboratory studies and not clinical studies. [17][18][19][20] To our knowledge, no clinical study examining intracameral amphotericin B therapy and including .5 patients has previously been reported in the literature, so the 12-patient, 14-eye study that we report here is the first of its scale. Results from previous laboratory or small-scale clinical studies have shown that amphotericin B injection is generally safe; Foster et al 16 found that, in a rabbit model, anterior chamber injection of as much as 50 mg amphotericin B failed to cause corneal or lenticular toxicity.…”

Section: Discussionmentioning

confidence: 95%

“…19,20 Kermani and Aggarwal 19 treated a case of Aspergillus niger endophthalmitis with 2 intracameral injections of 5 mg of amphotericin B in conjunction with oral itraconazole and reported successful resolution of the infection. In a case of Colletotrichum graminicola corneal ulcer, intracameral amphotericin B was repeated twice (in addition to repeated keratoplasties), and the infection was controlled.…”

Section: Discussionmentioning

confidence: 98%

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Efficacy of Intracameral Amphotericin B Injection in the Management of Refractory Keratomycosis and Endophthalmitis

Yilmaz

Ture

Maden

2007

Cornea

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 98%

Efficacy of Intracameral Amphotericin B Injection in the Management of Refractory Keratomycosis and Endophthalmitis

Yilmaz

Ture

Maden

2007

Cornea

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“…Ocular aspergillosis usually presents as keratitis, and rarely as endophthalmitis [92,184–187]. Post‐operative infections have been described following penetrating keratoplasty [188–190], radial keratotomy [191–194], excimer laser photo‐refractive keratectomy [195], laser‐assisted in‐situ keratomileusis [196–199], pterygium excision [200,201], hydroxyapatite orbital implant surgery [202], cataract surgery [179,184,203–212], scleral buckling procedures [213,214], sutureless surgery [215,216] and trabeculectomy [204,217].…”

Section: Literature Reviewmentioning

confidence: 99%

Post-operative aspergillosis

Pasqualotto

Denning

2006

Clinical Microbiology and Infection

160

173

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While invasive aspergillosis occurs typically in severely immunocompromised patients, cases of surgical site infection have been reported in immunocompetent individuals. The Medline, LILACS and EMBASE databases were searched for descriptions of cases of post-operative aspergillosis, and references from relevant articles and conference abstracts were reviewed. More than 500 cases of post-operative aspergillosis were found. Cardiac surgery (n = 188), ophthalmological surgery (n > 90) and dental surgery (n > 100) were associated with the majority of cases. Other cases involved wound infections (n = 22), bronchial infections (n = 30), mediastinitis (n = 11), pleural aspergillosis (n = 1), infections following orthopaedic surgery (n = 42), vascular prosthetic surgery (n = 22), breast surgery (n = 5), abdominal surgery (n = 10) and neurosurgery (n = 25). In most patients, the source was presumed to be airborne infection during the surgical procedure. Prevention of these infections requires special care of the ventilation system in the operating room. Successful treatment requires rapid diagnosis, surgical debridement and antifungal therapy, often with voriconazole. In order to improve the outcome, better diagnostic methods are needed, particularly for cases of endocarditis and aortitis.

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“…This organism causes endogenous ocular infections with chronic erosions/ulceration in immunocompromised hosts and compromised corneal surface (17) after trauma. From phaeohyphomycosis family, Curvularia is the third most prevalent filamentous hyphomycetes in corneal isolates in adults, with rate of 12% (32)(33)(34). Unfortunately, there is no report on FK by these fungi in pediatric patients.…”

Section: Signs and Symptomsmentioning

confidence: 99%

Management of Fungal Keratitis in Pediatric Patients

Badiee

Nejabat

Choopanizadeh

2017

Arch Pediatr Infect Dis

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Context: Fungal keratitis is an uncommon infection with high morbidity in pediatric patients. Trauma is the most common risk factor for infection in children. Thus, rapid diagnosis should be made by scoring clinical features and mycological examination. This review discusses the management of fungal keratitis in pediatric patients. Evidence Acquisition: In this narrative review, the most recently published data on pediatric fungal keratitis, respective prominent signs and symptoms, etiologic agents, diagnosis and treatment of this infection have been reviewed. Results: Laboratory methods such as investigation of smear by potassium hydroxide and staining and cultural and molecular methods can be helpful in the diagnosis. Treatment of this infection with improved outcome is challenging. Medical therapy (topical and systemic treatments) is the first choice of treatment, but early surgical intervention and removal of the infected tissues are critical for effective cure. Lack of response to these therapies requires corneal transplantation. Unfortunately, loss of useful vision rate was found in patients even with treatment by antifungal agents. Conclusions:The signs and symptoms of fungal keratitis are similar to those of other microbial keratitis. Use of diagnostic methods and early treatment are helpful for recovery in infected pediatric patients.

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Isolated post-operative Aspergillus niger endophthalmitis

Cited by 15 publications

References 7 publications

Efficacy of Intracameral Amphotericin B Injection in the Management of Refractory Keratomycosis and Endophthalmitis

Efficacy of Intracameral Amphotericin B Injection in the Management of Refractory Keratomycosis and Endophthalmitis

Post-operative aspergillosis

Management of Fungal Keratitis in Pediatric Patients

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