Isolated Pulmonary Langerhans Cell Histiocytosis in a 3-Year-old Girl With Atypical Radiologic Findings

Diffuse cystic lung disease in a child

“…[ 2 3 ] Though, typically upper and middle lung zones are predominantly affected with sparing of lung bases, diffuse involvement has been described in pediatric population (as in the present case). [ 4 5 6 ] Main differential diagnoses of cystic lung disease on HRCT, apart from pulmonary LCH, include lymphangioleiomyomatosis with/without tuberous sclerosis, emphysema and bronchiectasis, which can be differentiated based on combination of clinical and imaging findings. Lymphangioleiomyomatosis and lung disease due to tuberous sclerosis occur in females of child bearing age and on HRCT cysts are small, thin walled, more regular in shape and uniformly distributed.…”