Isolated Schneiderian papilloma of the middle ear cleft

Adams, Mark W.; Smith, Catherine A.; Hampton, Susanne

doi:10.1136/bcr-2018-228130

Cited by 4 publications

(1 citation statement)

References 4 publications

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“…There has been a correlation between certain HPV subtypes (6 and 11) and the development of this tumor in the sinonasal cavity. Albeit benign, this type of papilloma has a malignant potential especially if inadequately treated [15]. A meta-analysis of 31 case-controlled studies reported a statistically significant association of HPV 16 and 18 with malignant transformation of sinonasal IP [16].…”

Section: Discussionmentioning

confidence: 99%

Inverted Sinonasal Papilloma Involving the Middle Ear with Evidence of Squamous Cell Carcinoma

Alghamdi

Aldohan

Alotaibi

et al. 2019

Cureus

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Inverted papilloma is an uncommon benign epithelial tumor that typically affects the nasal cavity and originates from the lateral sinonasal wall. Inverted papilloma occurring in the middle ear is an even more rare and aggressive condition. We describe a case of a 76-year-old man who was treated for isolated sinonasal inverted papilloma and after 20 months he was found to have a recurrence in the nasal cavity with middle ear involvement and malignant changes consistent with nonkeratinizing squamous cell carcinoma arising from inverted papilloma. Several surgical procedures were required to remove the tumor along with radiation therapy postoperatively.

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Section: Discussionmentioning

confidence: 99%

Inverted Sinonasal Papilloma Involving the Middle Ear with Evidence of Squamous Cell Carcinoma

Alghamdi

Aldohan

Alotaibi

et al. 2019

Cureus

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Middle Ear and Temporal Bone Papilloma: A Clinicopathologic Study and Comprehensive Literature Review of 57 Cases

Thompson

2021

Head and Neck Pathol

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Inverted Papilloma of the Middle Ear: Two New Cases and Systematic Review

Miller

Walsh

Cho

et al. 2022

Allergy�Rhinol (Providence)

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Introduction Inverted papillomas of the middle ear are extremely rare tumors that carry an increased risk of recurrence and malignant transformation. There are currently 59 cases of middle ear inverted papillomas reported in the literature. The objective in this study was to systematically evaluate outcomes regarding middle ear inverted papillomas with respect to demographics, anatomical tumor sites, malignant transformation status, recurrence rate and HPV status. Study Design Retrospective case series and systematic review. Methods A systematic review was completed on June 25, 2020 with a search strategy including PubMed, Embase, Scopus and Google Scholar. This revealed 181 articles. Full-text review was completed, and 66 articles were included. 115 articles were eliminated due to duplication of articles from databases, article titles not applicable to the aims of the systematic review and articles describing inverted papilloma of body sites other than middle ear. Discussion Thirty-one cases of primary inverted papillomas of the middle ear were found in the literature with an additional 26 cases of secondary tumors. Four case reports did not specify primary versus secondary. The malignant transformation rate was 34.4% with a 53.6% recurrence rate. Treatment of middle ear inverted papillomas is primarily surgical with adjuvant radiation therapy considered for patients with recurrence or malignant transformation. Frequent clinical follow up of these patients is critical due to the increased rate of recurrence and malignant transformation. Conclusion Inverted papillomas of the middle ear are rare tumors that carry a high risk of recurrence and malignant transformation necessitating complete resection and frequent clinical follow up.

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Isolated Schneiderian papilloma of the middle ear cleft

Cited by 4 publications

References 4 publications

Inverted Sinonasal Papilloma Involving the Middle Ear with Evidence of Squamous Cell Carcinoma

Inverted Sinonasal Papilloma Involving the Middle Ear with Evidence of Squamous Cell Carcinoma

Middle Ear and Temporal Bone Papilloma: A Clinicopathologic Study and Comprehensive Literature Review of 57 Cases

Inverted Papilloma of the Middle Ear: Two New Cases and Systematic Review

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