Isolated splenic metastasis of endometrial cancer 12 years after treatment

Yu, Hong

doi:10.1097/md.0000000000029178

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…Splenic metastasis is unusual and well known as the spleen is rarely subject to malignancy due to its special anatomical architecture and microenvironment. 20 The clinical situation and tumoral spreading behavior can help predict the possibility of splenic metastasis at an advanced stage of cancer. 9 Some authors reported the presence of splenic metastasis in unexpected, controlled cases.…”

Section: Discussionmentioning

confidence: 99%

Solitary Splenic Metastasis from Rectal Cancer; A case report and literature review.

Albahkali

2024

Preprint

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Background: Metastasis to the spleen is rarely seen on imaging and has been little reported in the literature, requires for early diagnosis and a surveillance staging protocol to get a guide for management at the onset of metastatic diseases, and it can occur at the advanced stages of the disease or posttreatment follow-up evaluation. Case Presentation: A 59-year-old Saudi female patient diagnosed with rectal adenocarcinoma with metachronous metastatic hepatic and splenic lesions. Clinical examination of the abdomen was rigid with the development of splenomegaly. post-chemotherapy and laparoscopic-assisted diverting colostomy. She has high (CEA) markers and normal levels of hemoglobin. However, we knew she may relapse based on an advanced stage, thus, the progression of the disease was reported in the form of hepatic (82%) and splenic (46%) lesions. Conclusion: Splenic metastasis is an unusual entity, an incidental finding of radiological examination, requiring further investigation to confirm the malignant character. The standard method in therapeutic strategies for splenic metastasis has not been constituted. Known treatment options include splenectomy, chemotherapy, and radiotherapy.

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Section: Discussionmentioning

confidence: 99%

Solitary Splenic Metastasis from Rectal Cancer; A case report and literature review.

Albahkali

2024

Preprint

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“…Isolated splenic metastasis of endometrioid cancer is also rare, with only 19 cases reported in the literature [ 37 , 38 ]. Previous studies have reported that splenic metastases are often identified as solitary lesions [ 37 , 38 ]; however, two lesions have been occasionally observed [ 38 ]. No reports have documented more than three lesions in the spleen, as observed in the present cases.…”

Section: Discussionmentioning

confidence: 99%

Splenic sarcoid reaction mimicking metastases in patients after uterine cancer surgery: a report of two cases

Kitamura,

Ogura,

Miyamoto

et al. 2023

surg case rep

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Background Tumor-associated sarcoid reactions have been observed with various tumors; however, they have not been reported with uterine cancer. We present two cases of splenic sarcoid reactions that mimicked metastases a few years after uterine cancer surgery. Case presentation Case 1 involved a 67-year-old female patient diagnosed with endometrial cancer (pT1aN0M0, pStage Ia, grade 1). The patient underwent open total abdominal hysterectomy and bilateral salpingo-oophorectomy with pelvic lymphadenectomy. Three years after the initial surgery, computed tomography (CT) and positron emission tomography CT showed multiple splenic masses with increasing numbers and sizes. Splenic metastases were diagnosed, and laparoscopic splenectomy was performed. The histopathological analysis revealed sarcoid reactions in the spleen. Case 2 involved a 47-year-old female patient diagnosed with endometrial cancer (pT1aN0M0, pStage Ia, grade 1). The patient underwent laparoscopic total abdominal hysterectomy and bilateral salpingo-oophorectomy with pelvic lymphadenectomy. Two years after the initial surgery, multiple splenic masses were observed. We performed laparoscopic splenectomy for the splenic metastases. Granuloma formations were identified in the splenic specimen and perisplenic lymph nodes that were removed simultaneously, resulting in a final diagnosis of sarcoid reaction. A review of the lymph nodes at the time of the previous uterine surgery revealed granuloma formation. Other than the presence of splenic masses, no findings suggestive of recurrence were observed in these cases. Uterine cancer and sarcoid reactions progressed without recurrence after splenectomy. Conclusions To the best of our knowledge, this is the first report of the late development of splenic sarcoid reactions after uterine cancer surgery. Sarcoid reactions and metastases are difficult to diagnose based on preoperative imaging results. However, reviewing the specimen at the time of the initial resection, the number of lesions, and the clinical findings (other than imaging findings) may aid in the determination of the correct diagnosis.

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Diagnostic and therapeutic challenges in a recurrent endometrial carcinoma in lung, 15 years after primary treatment

Upadhyay,

Kumar,

Prakash

et al. 2024

BMJ Case Rep

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Endometrial carcinoma (EC) is the sixth most common cancer in females. Most ECs are detected in stage 1 and have a 5-year survival rate of more than 90%. Recurrence rates are highest within 5 years after treatment and are exceptionally rare after 10 years. Here, we describe a woman in her late 70s with endometrial cancer who was treated in 2008 and was diagnosed with a relapse in her left lung in 2023. Due to her advanced age and comorbidities, she was deemed inoperable. However, she received sequential chemotherapy and radiotherapy with a good partial response. She has now been started on hormonal therapy with an alternate megestrol and tamoxifen regime. There is a lack of follow-up imaging guidelines to detect late relapse, a dilemma in preferred treatment sequencing at relapse and an enigma in selecting chemotherapy or hormonal therapy.

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Isolated splenic metastasis of endometrial cancer 12 years after treatment

Cited by 3 publications

References 19 publications

Solitary Splenic Metastasis from Rectal Cancer; A case report and literature review.

Solitary Splenic Metastasis from Rectal Cancer; A case report and literature review.

Splenic sarcoid reaction mimicking metastases in patients after uterine cancer surgery: a report of two cases

Diagnostic and therapeutic challenges in a recurrent endometrial carcinoma in lung, 15 years after primary treatment

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