Isolated thrombocytopenia a rare presenting feature of enteric fever

Charan, Shiv; Chander, Rakesh; Singh, Inderpal

doi:10.18203/2349-3933.ijam20161107

Cited by 3 publications

(4 citation statements)

References 8 publications

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“…The thrombocytopenia recovered in the first week of ceftriaxone therapy. 13 Khosla SN, Anand A et al, studied the Haematological profile in 20 culture proven cases of Enteric fever. They found anaemia, leucopenia, eosinopenia, thrombocytopenia and sub clinical DIC.…”

Section: Discussionmentioning

confidence: 99%

Complicated enteric fever: a case series

2020

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Enteric fever is endemic in Indian subcontinent. Authors are presenting 3 rare cases of complicated enteric fever. The first case is a case of enteric fever which was complicated by ARDS leading to respiratory failure. The second case is a case of enteric fever which was complicated by severe thrombocytopenia and the third case is a case of enteric fever which was complicated by severe encephalopathy. In this study authors have discussed and compared the similar cases found in India and other parts of the world. The physicians who are taking care of the patients of enteric fever should be aware of the above complications.

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Section: Discussionmentioning

confidence: 99%

Complicated enteric fever: a case series

2020

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“…Leucopenia and anaemia are well-recognised haematological manifestations of enteric fever. Isolated thrombocytopenia is a rare finding in typhoid fever, and there are only few case reports found in the literature [ 11 ]. Our patient had both leucopenia and thrombocytopenia at presentation without anaemia, which is a common finding in febrile patients due to viral aetiology particularly dengue infection.…”

Section: Discussionmentioning

confidence: 99%

Typhoid Fever due to Extended Spectrum β-Lactamase-Producing Salmonella enterica Serovar Typhi: A Case Report and Literature Review

Riyaaz

Perera²,

Sivakumaran

et al. 2018

Case Reports in Infectious Diseases

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Emergence of cephalosporin-resistant strains of Salmonella enterica serovar Typhi is a cause of concern in the management of enteric fever. Cephalosporin resistance in Salmonella species is mainly due to the production of extended-spectrum β-lactamases (ESBLs). The majority of ESBLs in Salmonella enterica serovar Typhi are derivatives of the TEM, SHV, and CTX-M β-lactamase families. Of these, CTX-M appears to be predominant. This paper discusses the detection and molecular characterization of an ESBL-producing Salmonella enterica serovar Typhi strain isolated from a patient who was admitted to a private hospital in Sri Lanka. The three main types of β-lactamases such as TEM, SHV, and CTX-M were identified in this isolate. This case report from Sri Lanka contributes to the knowledge of the increasingly reported cases of typhoid fever due to Salmonella enterica serovar Typhi resistant to β-lactamase by ESBL production.

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“…The Salmonella species were isolated according to the methods described by Cheesebrough [21] and also methods outlined by the WHO [14].…”

Section: Isolation Of Bacteriamentioning

confidence: 99%

“…Other gram-negative bacteria that possess these include Aeromonas spp., Acinetobacter spp., and Pseudomonas spp. Plasmid-carried β-lactamase genes are most commonly found in the Enterobacteriaceae, but may also be found in some species of grampositive bacteria such as Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium" [19,21]. The aim of this study was to assess the Extended Spectrum Beta-Lactamase (ESBL) resistant genes in Salmonella spp isolated from ready-to-eat foods and food handlers in Port Harcourt Metropolis, Nigeria.…”

Section: Introductionmentioning

confidence: 99%

Extended Spectrum Beta-Lactamase (ESBL) Resistant genes in Salmonella species Isolated from Ready-to-eat Foods and Food Handlers in Port Harcourt Metropolis, Nigeria

Ndu

Nwokah²,

Ollor³

et al. 2022

IJPR

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Aim: To assess the Extended Spectrum Beta-Lactamase (ESBL) resistant genes in Salmonella spp isolated from ready-to-eat foods and food handlers in Port Harcourt Metropolis, Nigeria. Study Design: A cross-sectional study. Place and Duration of Study: This study was conducted in selected places in Port Harcourt, between November 2019 and June 2021. Methodology: A total of 350 food specimens and 230 food handlers were collected and the social demographic information were collected using a questionnaire survey. The samples were analysed for contamination with Salmonella species using conventional and molecular methods. Salmonella species were isolated from samples using Salmonella-Shigella agar (SSA), Xylose-lysine desoxycholate agar (XLD), MacConkey agar (MA), Blood agar (BA) after pre-enrichment and enrichment method has been done using peptone water broth and Selenite F. Salmonella Chromogenic medium (SCM) was also used to confirm the isolate. Antibiotic susceptibility patterns of the Salmonella isolates were determined using Kirby Bauer disk diffusion method. The presence of Extended Spectrum Beta Lactamase genes (CTX-M, SHV, and TEM) in the Salmonella isolates were screened using double disc synergy method and also investigated using Polymerase chain reaction (PCR) technique. Results: Results showed that of the 11 Salmonella species isolated from the food handlers, 7(63.6%) harboured extended spectrum beta-lactamase (ESBL) genes while 18 (64.3%) out of 28 Salmonella isolated from street vended food sample were positive for ESBL genes. However, there was no significant difference in the proportion of ESBL producers observed in the street vended food and those in food handlers’ sample (P= 0.964) PCR result revealed the presence of genes encoding for TEM, SHV and CTX-M. Conclusion: Street vended foods such as white rice/stew, jollof rice, rice/beans stew, porridge beans, beans/stew, moi moi, abacha, and roasted plantain in Port Harcourt harbour Salmonella species that possess the following Extended Spectrum Beta Lactamase (ESBL) genes as CTX-M, SHV and TEM. This should receive particular attention, as the presence of extended spectrum beta-lactamase genes isolated, indicate public health hazard and gives a warning signal for the possible occurrence of food borne diseases and multi-drug resistance.

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Isolated thrombocytopenia a rare presenting feature of enteric fever

Cited by 3 publications

References 8 publications

Complicated enteric fever: a case series

Complicated enteric fever: a case series

Typhoid Fever due to Extended Spectrum β-Lactamase-Producing Salmonella enterica Serovar Typhi: A Case Report and Literature Review

Extended Spectrum Beta-Lactamase (ESBL) Resistant genes in Salmonella species Isolated from Ready-to-eat Foods and Food Handlers in Port Harcourt Metropolis, Nigeria

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