Isolated vitamin D supplementation improves the immune-inflammatory biomarkers in younger postmenopausal women: a randomized, double-blind, placebo-controlled trial

Bueloni-Dias, Flávia Neves; Orsatti, Cláudio Lera; Cangussu, Luciana Mendes; Poloni, Priscila Ferreira; Dias, D.S.; Nahás-Neto, Jorge; Nahas, Eliana A.

doi:10.1097/gme.0000000000001106

Cited by 14 publications

(15 citation statements)

References 43 publications

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“…The final column details reported statistical effect of Vitamin D at lowering IL-6 level. Reference Location Condition Age (yrs] N Duration (wks] D3 Dose (IU/day) Outcome Bueloni-Dias [39] Brazil Healthy Women 57 ± 7 160 39 1000 p < 0.05 Costenbader [40] Boston Healthy Older Adults 65 ± 8 1561 52 2000 p > 0.05 Duggan [41] Seattle Overweight Women 62 ± 12 218 52 2000 p = 0.004 Goncalves-Mendes [42] France Healthy Older Adults 71 ± 6 38 13 6667 p = 0.046 Hashemi [43] Iran Multiple Sclerosis 30 ± 9 75 8 7143 p < 0.001 Hashemi [44] Iran Multiple Sclerosis 30 ± 10 75 8 7143 p < 0.001 Miroliaee [45] Iran Ventilator Pneumonia 56 ± 20 46 Single 300,000 p = 0.01 Reid [46] St Louis Asthma 40 ± 13 100 12 4000 p > 0.05 Stepanova [47] Russia Type 2 Diabetes Not Stated 62 …”

Section: Resultsmentioning

confidence: 99%

Correlation between premorbid IL-6 levels and COVID-19 mortality: Potential role for Vitamin D

Silberstein

2020

International Immunopharmacology

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Highlights Interleukin IL-6 facilitates COVID-19 viral cell entry and replication. Healthy IL-6 levels correlate with COVID-19 morbidity in similar matched populations. Vitamin D administration appears to lower IL-6 levels in humans. IL-6 modulation with Vitamin D and other means may be a useful therapeutic strategy in COVID-19.

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Section: Resultsmentioning

confidence: 99%

Correlation between premorbid IL-6 levels and COVID-19 mortality: Potential role for Vitamin D

Silberstein

2020

International Immunopharmacology

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“…The increased IL-6 observed in the supplemented children is consistent with in vitro studies showing that macrophages and monocytes up-regulate IL-6 expression upon vitamin D stimulus (1) and IL-6 expression is up-regulated in the peripheral blood mononuclear cells of vitamin D supplemented multiple sclerosis patients (14). At the same time vitamin D supplementation was found to down-regulate IL-6 in some studies (15-18). These seemingly contradictory findings regarding IL-6 and vitamin D could be attributed to various confounders and differences among the studies, such as the duration and dosage of vitamin D supplementation, the participants’ genetic background, underlying clinical conditions and extent of vitamin D insufficiency/deficiency at baseline.…”

Section: Discussionmentioning

confidence: 96%

“…In this study the supplemented group's 25(OH)D 3 concentrations increased gradually reaching 49 nmol/L at six months, while the un-supplemented adolescents remained severely deficient with blood 25(OH)D 3 levels remaining <25 nmol/L throughout the study, (14). At the same time vitamin D supplementation was found to down-regulate IL-6 in some studies (15)(16)(17)(18).…”

Section: Discussionmentioning

confidence: 98%

Effects of vitamin D supplementation and seasonality on circulating cytokines in adolescents: analysis of data from a feasibility trial in Mongolia

Yegorov

Bromage

Boldbaatar

et al. 2019

Preprint

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Vitamin D deficiency is prevalent in human populations and has been linked to immune dysfunction. Here we explored the effects of cholecalciferol supplementation on circulating cytokines in severely vitamin D deficient (blood 25(OH)D3 << 30 nmol/L) adolescents aged 12-15 from Mongolia. The study included 28 children receiving 800 IU daily cholecalciferol for 6 months spanning winter and spring, and 30 children receiving placebo during the same period. The levels of 25(OH)D3 were assessed at baseline, three and six months. Twenty-one cytokines were measured in serum at baseline and at six months. The median blood 25(OH)D3 concentration at baseline was 13.7 nmol/L (IQR=10.0-21.7). Supplementation tripled blood 25(OH)D3 levels (p<0.001) and reversed the direction of change for most cytokines (16/21, 86%). Supplementation was associated with elevated interleukin (IL)-6 (p=0.043). The placebo group had reduced MIP-1α (p=0.007) and IL-8 (p=0.034) at six months. These findings suggest that cholecalciferol supplementation and seasonality have a measurable impact on circulating cytokines in adolescents, identifying chemokines as potentially important biomarkers of vitamin D status in this population.

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“…The increased IL-6 observed in the supplemented children is consistent with IL-6 up-regulation in the peripheral blood mononuclear cells of vitamin D supplemented multiple sclerosis patients (24). At the same time vitamin D deficiency was associated with high IL-6 (25) and vitamin D supplementation down-regulated IL-6 in some studies (26–29). These seemingly contradictory findings regarding IL-6 and vitamin D could be attributed to various confounders and differences among the studies, such as the duration and dosage of vitamin D supplementation, the participants' genetic background, underlying clinical conditions, effects of clinical therapy, and extent of vitamin D insufficiency/deficiency at baseline.…”

Section: Discussionmentioning

confidence: 99%

Effects of Vitamin D Supplementation and Seasonality on Circulating Cytokines in Adolescents: Analysis of Data From a Feasibility Trial in Mongolia

et al. 2019

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Vitamin D deficiency is prevalent in human populations and has been linked to immune dysfunction. Here we explored the effects of cholecalciferol supplementation on circulating cytokines in severely vitamin D deficient [blood 25(OH)D << 30 nmol/L] adolescents aged 12–15 from Mongolia. The study included 28 children receiving 800 IU daily cholecalciferol for 6 months spanning winter and spring, and 30 children receiving placebo during the same period. The levels of 25(OH)D were assessed at baseline, 3 and 6 months. Twenty-one cytokines were measured in serum at baseline and at 6 months. Changes in 25(OH)D and cytokines were assessed using paired parametric tests. The median blood 25(OH)D concentration at baseline was 13.7 nmol/L (IQR = 10.0–21.7). Supplementation tripled blood 25(OH)D levels (p < 0.001) and was associated with elevated interleukin (IL)-6 (p = 0.043). The placebo group had reduced macrophage inflammatory protein (MIP)-1α (p = 0.007) and IL-8 (p = 0.034) at 6 months. Although limited by a small sample size, these findings suggest that cholecalciferol supplementation and seasonality may impact systemic immunity in adolescents, identifying chemokines as potentially important biomarkers of vitamin D status in this Northeast Asian population. Larger clinical trials are warranted to validate these results.Clinical Trial Registration: www.ClinicalTrial.org, Identifier: NCT01244204.

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Isolated vitamin D supplementation improves the immune-inflammatory biomarkers in younger postmenopausal women: a randomized, double-blind, placebo-controlled trial

Abstract: In younger postmenopausal women, isolated supplementation with 1000 IU of VitD3 for 9 months was associated with a reduction in proinflammatory biomarkers.

Cited by 14 publications

References 43 publications

Correlation between premorbid IL-6 levels and COVID-19 mortality: Potential role for Vitamin D

Correlation between premorbid IL-6 levels and COVID-19 mortality: Potential role for Vitamin D

Effects of vitamin D supplementation and seasonality on circulating cytokines in adolescents: analysis of data from a feasibility trial in Mongolia

Effects of Vitamin D Supplementation and Seasonality on Circulating Cytokines in Adolescents: Analysis of Data From a Feasibility Trial in Mongolia

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