Isolates of  Alpinia officinarum  Hance as COX-2 inhibitors: Evidence from anti-inflammatory, antioxidant and molecular docking studies

Honmore, Varsha S.; Kandhare, Amit D.; Kadam, Parag P.; Khedkar, Vijay M.; Sarkar, Dhiman; Bodhankar, Subhash L.; Zanwar, Anand A.; Rojatkar, Supada R.; Natu, Arun D.

doi:10.1016/j.intimp.2016.01.024

Cited by 105 publications

(71 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[41][42][43][44] Several lines of studies reported that GM-induced GSH level depletion might be due to excess generation of free radicals or increased consumption in the protection of -SH group-containing proteins and decreased SOD antioxidant enzymes associated with overproduction of superoxide anions and hydrogen peroxide. 18,[45][46][47] In consistent with the previous finding, our results showed that GM administration increased MDA level as an end product of lipid peroxidation while decreased GSH and SOD levels in renal tissue.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction

et al. 2016

Self Cite

View full text Add to dashboard Cite

Background: Gentamicin (GM) is the commonly used antibiotics against Gram-negative infection, but the nephrotoxic potential of drug limit its clinical interest. The aim of this study was to investigate the protective effect of berberine (BER) against GM-induced nephrotoxicity and possible underlying mechanisms. Material and methods: The rats were divided into various group, namely normal, GM-control, GM þ BER (10, 20, and 40 mg/kg). Nephrotoxicity was induced by intraperitoneal administration of GM (120 mg/kg) for 7 consecutive days. BER (10, 20, and 40 mg/kg; p.o.) was also administered for the 7 days. Various biochemical, molecular, and histological parameters were assessed in serum and kidney. Results: GM-administration significantly increased (p < 0.001) the serum creatinine and blood urea nitrogen (BUN) as well as renal malonaldehyde (MDA), nitric oxide (NO) along with Kidney Injury Molecule-1 (KIM-1), Neutrophil gelatinase-associated lipocalin (NGAL), and nuclear factor-kappa B (NF-KB) renal mRNA expressions. In addition, GM also significantly decreased (p < 0.001) the renal superoxide dismutase (SOD), reduced glutathione (GSH), B-cell lymphoma 2 (Bcl-2) mRNA expression, and mitochondrial enzymes (NADH dehydrogenase and cytochrome c oxidase) activities. Rats treated with BER (20 and 40 mg/kg; p.o.) significantly and dose-dependently (p < 0.05 and p < 0.01) restore the altered levels of antioxidant, inflammatory, apoptosis, AKI markers as well as depleted mitochondrial enzymes. Histopathological abbreviations were also ameliorated by BER administration. Conclusion: Berberine exerts renoprotective effects through its anti-oxidant, anti-inflammatory, and anti-apoptotic properties.

show abstract

Section: Discussionmentioning

confidence: 99%

Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…[34] The extract showed inhibition of right hind paw edema on carrageenan-induced inflammation in rats and promising free radical scavenging effect of DPPH in a concentration-dependent manner up to a concentration of 100 μg/ml. Ghil reported the ability of A. officinarum rhizome methanolic extract to inhibit cell proliferation in a dose- and time-dependent manner against human breast cancer cell line MCF-7, by promoting cell cycle arrest, hence triggering cell apoptosis.…”

Section: Solvent Extracts/fractions and Isolated Compounds Of Alpiniamentioning

confidence: 99%

“…[34] The ethyl acetate fraction from this extract had isolated compound 5 and 5-hydroxy-7-(4’-hydroxy-3’-methoxyphenyl)-1-phenylheptan-3-one (21) that has shown its effectiveness in acute inflammatory animal model, comparable to a clinical non-steroidal anti-inflammatory drug, diclofenac, that acts as the positive control. The compounds have displayed a significant inhibition of the increase in the carrageenan-induced paw edema in a time-dependent manner, as well as in vitro scavenging activity in a concentration-dependent manner.…”

Section: Solvent Extracts/fractions and Isolated Compounds Of Alpiniamentioning

confidence: 99%

“…The compounds have displayed a significant inhibition of the increase in the carrageenan-induced paw edema in a time-dependent manner, as well as in vitro scavenging activity in a concentration-dependent manner. [34] In another study, the ethyl acetate fraction of acetone crude extract showed a more potent activity compared to other solvent extracts (acetone and aqueous) and was responsible for the isolation of compounds 5, 9, 21, pinobaksin (22), 5-hydroxy-1,7-diphenyl-3-heptanone (23), 7-(4’’-hydroxy-3’’-methoxyphenyl)-1-phenylhept-4-en-3-one (24), 3,5-dihydroxy-1,7-diphenylheptane (25), 3-phenylpropanoic acid (26), and zingerone (27). Only compounds 5, 24, and 25 showed the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced murine RAW 264.7 macrophage cell line while, as melanogenesis inhibitors, compounds 5, 9, 21, 23, 24, and 25 substantially inhibited melanogenesis in theophylline-stimulated B16 melanoma 4A5 cells, and in addition, compounds 5, 9, and 24 inhibited the enzyme activity of mushroom tyrosinase.…”

Section: Solvent Extracts/fractions and Isolated Compounds Of Alpiniamentioning

confidence: 99%

See 1 more Smart Citation

A review on the pharmacological activities and phytochemicals of Alpinia officinarum (Galangal) extracts derived from bioassay-guided fractionation and isolation

Basri¹,

Taha²,

Ahmad³

2017

Phcog Rev

103

View full text Add to dashboard Cite

The rhizomes of Alpinia officinarum Hance have been used conventionally for the treatment of various ailments, triggering a wide interest from the scientific research community on this ethnomedicinal plant. This review summarizes the phytochemical and pharmacological properties of the extracts and fractions from A. officinarum, a plant species of the Zingiberaceae family. Different parts of the plant – leaves, roots, rhizomes, and aerial parts – have been extracted in various solvents – methanol, ethanol, ethyl acetate, hexane, dichloromethane, aqueous, chloroform, and petroleum ether, using various techniques – Soxhlet extraction, maceration, ultrasonication, and soaking, whereas fractionation of the plant extracts involves the solvent–solvent partition method. The extracts, fractions, and isolated compounds have been studied for their biological activities – antioxidant, antibacterial, anti-inflammatory, anticancer, antiproliferative, inhibition of enzymes, as well as the inhibition of nitric oxide production. More findings on A. officinarum are certainly important to further develop potential bioactive drug compounds.

show abstract

“…The role of LTC 4 in allergic asthma has been extensively evaluated (85). LTC 4 is produced in mast cells by assembly of a biosynthetic complex at the nuclear envelope, consisting of cytosolic phospholipase A2 (cPLA2), (64) Oxi-CaMKII inhibitor KN-93 KN-93 significantly decreased goblet cell hyperplasia, bronchial epithelial thickness, airway eosinophilia, the eosinophil chemoattractant molecule, Ccl-11, and NF-κB activity in allergic asthma (61) Leukotriene C4 (LTC 4 ) inhibitor A LTC 4 inhibitor reduced NOX4 levels and attenuated cell death (32) Galangin Galangin demonstrated decreased airway remodeling, angiogenic activity, and ASMC proliferation through the TGF-β1-ROS-MAPK pathway (65)(66)(67) Astragalin Astragalin suppressed LPS-induced ROS production and eotaxin-1 expression in epithelial cells through the TLR4-PKCγ1-PKCβ2-NADPH signaling pathway (68,69) Glutathione GSH balances Th1/Th2 responses, alters nitric oxide metabolism and inhibits ROS (55,59,70) SOD SODs protects against the harmful effects of ROS and airway inflammation (71)(72)(73) Glutathione peroxidases Glutathione peroxidases prevent airway inflammation and alveolar destruction (74)(75)(76) Vitamins C and E Vitamins C and E reduce AHR, inflammation, and oxidative stress (77)(78)(79) TLR7, toll-like receptor 7; Oxi-CaMKII, oxidative-CaMKII; SOD, superoxide dismutase; AHR, airway hyper-reactivity; Nrf2, nuclear factor E2-related factor 2; Cu/Zn SOD, copper/zinc superoxide dismutase; ROS, reactive oxygen species; NOX4, NADPH oxidase 4; LPS, lipopolysaccharide; Th2, type 2 helper T.…”

Section: Ltc 4 Inhibitorsmentioning

confidence: 99%

Recent developments in the role of reactive oxygen species in allergic asthma

Zhong

et al. 2017

J. Thorac. Dis.

132

View full text Add to dashboard Cite

Allergic asthma has a global prevalence, morbidity, and mortality. Many environmental factors, such as pollutants and allergens, are highly relevant to allergic asthma. The most important pathological symptom of allergic asthma is airway inflammation. Accordingly, the unique role of reactive oxygen species It is well known that reactive oxygen species (ROS), endogenous nitric oxide (NO) and NO derived reactive nitrogen species (RNS) have been reported to mediate oxidative stress and airway inflammation and pathogenesis. However, ROS are more common in allergic asthma development (6,7). Hence, in our review, we mainly focus on the relationship between ROS and allergic asthma. ROS, such as hydrogen peroxide, may be directly or indirectly involved in epithelial cell apoptosis and inactivation of antioxidant enzymes and contribute to allergic asthma (8-11). ROS are derived from endogenous or exogenous oxidants. Endogenous ROS are composed of mitochondria, NADPH, and the xanthine/xanthine oxidase (XO) system. Exogenous sources of ROS production have been linked to strong oxidizing gases, such as ozone (O 3 ), sulfur dioxide (SO 2 ), nitrogen dioxide (NO 2 ) and particulate matter (PM), which are a major component of air pollution (12,13). The oxygen stress level in asthma is increased because of inflammatory cells in vivo, and cigarette smoke (CS) or PM produces ROS in vitro. For example, compared with normal subjects, the level of H 2 O 2 and superoxide that are produced by eosinophils and neutrophils are significantly increased in asthma patients (14). Increased levels of ROS can cause harmful pathophysiological disorders of allergic asthma. Studies have reported that excessive ROS can damage DNA, carbohydrates, proteins, and lipids, ultimately leading to an increased inflammatory response in allergic asthma (15,16). In this review, we will discuss the updated pathophysiological and mechanisms of oxidative stress relating to allergic asthma. Exogenous oxidants and allergic asthmaPatients' exposure to the environmental atmosphere is the main way that exogenous oxidative stress is induced (17). CS is a complex mixture including more than 4,000 different compounds. It has been demonstrated that inhaled CS can increase ROS levels. Most of these compounds have ability to generate ROS during their metabolism. The mechanism of CS induced inflammation is incorporated with oxidative stress leading to cell death and oxidative DNA damage via apoptosis and/or necrosis (7). It was reported that antioxidants have the ability to protect cells from cigarette smoke extract (CSE) induced apoptosis (18). Isolated human airway smooth muscle (hASM) cells were used to determine Ca 2+ responses and hASM proliferation, as well as ROS level and cytokine generation, by incubating these cells in the presence or absence of CSE. The results revealed that Ca 2+ regulatory proteins alter airway remolding and function in smoking-related airway disease, especially allergic asthma (19). CSE can damage bronchial epithelial cells from asthm...

show abstract

Isolates of Alpinia officinarum Hance as COX-2 inhibitors: Evidence from anti-inflammatory, antioxidant and molecular docking studies

Cited by 105 publications

References 43 publications

Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction

Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction

A review on the pharmacological activities and phytochemicals of Alpinia officinarum (Galangal) extracts derived from bioassay-guided fractionation and isolation

Recent developments in the role of reactive oxygen species in allergic asthma

Contact Info

Product

Resources

About