Isolation and amino acid sequence of caerulein, the active decapeptide of the skin of Hyla caerulea

Ánastasi, A.; Erspamer, V.; Exdean, R.

doi:10.1016/0003-9861(68)90638-3

Cited by 199 publications

(56 citation statements)

References 18 publications

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“…Indeed, desulphated caerulein was 50-100 times less active than caerulein on the dog blood pressure (Anastasi et al, 1968).…”

Section: Resultsmentioning

confidence: 94%

“…Pure caerulein was obtained by a procedure described in detail elsewhere (Anastasi et al, 1967(Anastasi et al, , 1968 Quantitative estimation of caerulein was carried out by bioassay, using dog blood pressure and, subordinately, the contraction of the in situ gall bladder of the guinea-pig.…”

Section: Reagents and Drugsmentioning

confidence: 99%

“…Further details of the methods can be found in previous publications (Erspamer, Vitali, Roseghini & Cei, 1967;Anastasi & Erspamer, 1962;Anastasi et al, 1968).…”

Section: Paper Chromatographymentioning

confidence: 99%

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OCCURRENCE OF CAERULEIN IN EXTRACTS OF THE SKIN OF HYLA CAERULEA AND OTHER AUSTRALIAN HYLIDS

Endean

Erspamer

et al. 1968

British Journal of Pharmacology and Chemotherapy

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“…Indeed, desulphated caerulein was 50-100 times less active than caerulein on the dog blood pressure (Anastasi et al, 1968).…”

Section: Resultsmentioning

confidence: 94%

Section: Reagents and Drugsmentioning

confidence: 99%

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OCCURRENCE OF CAERULEIN IN EXTRACTS OF THE SKIN OF HYLA CAERULEA AND OTHER AUSTRALIAN HYLIDS

Endean

Erspamer

et al. 1968

British Journal of Pharmacology and Chemotherapy

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“…The protein concentration of the pancreatic juice in conscious chicken was increased slightly by the instillation of the pepton solution.Unfortunately we could not determine the action of cholecystokinin-pancreozymine(CCK-PZ)on the exocrine pancreas in chickens.It has been reported that caerulein which is similar to CCK-PZ chemically and biologically (ANASTASI et al,1968;BERTACCINI et al,1969)has a strong stimulating action on the pancreatic volume and protein secretions in chickens (ANGELLUCII et al,1970).The participation of CCK-PZ in the mechanism of the exocrine pancreas in chicken awaits further study.…”

Section: Contents Of Sn-like Substance In Chickensratsand Dogsmentioning

confidence: 98%

The Endogenous Secretin in Chicken: Minor Physiological Role in Exocrine Pancreatic Secretion

Kokue

Hayama

1976

Jpn.J.Physiol

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The action of secretin (SN) on the exocrine pancreas in the chicken was studied in comparison with the rat and dog. Hydrochloric acid (0.1N), pepton (5%) and olive oil were introduced into the small intestine of conscious chickens with chronic pancreatic fistula and caused the volume and protein output to increase slightly in about two-thirds of the chickens tested. The percent increase of the volume output in anesthetized chickens by HCl instillation was only one-tenth of that in the rat. Acid extracts of the intestinal mucosa (80mg) from chickens when given intravenously to rats caused the volume of secretion from the rat pancreas to increase about twofold, whereas the extracts from the dogs' and rats' intestine increased the volume output 5.9 and 5.5 times respectively. The increase of pancreatic secretion in chickens by intravenous injection of commercial SN was about one-third of that in the rat. The present studies indicate that SN or a SN-like hormone may be present in the chicken, but it plays only a minor physiological role.

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“…In this study, we used the discrete shuttle avoidance response in mice to further assess the effect of a comparatively lower dose of MK-801 through combined administration with the cholecystokinin-like decapeptide ceruletide (5). The systemic administration of this pep tide, at over 10 ,ug/kg, significantly reduced the ambulation-increasing and response-in creasing effects of methamphetamine (0.5-2 mg/kg) (6,7).…”

mentioning

confidence: 99%

Differential Antagonism of the Stimulant Effects of MK-801 and Methamphetamine by Ceruletide: Evaluation by Discrete Shuttle Avoidance Response in Mice.

Kuribara¹,

Tadokoro²

1991

Jpn.J.Pharmacol

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ABSTRACT-A noncompetitive NMDA antagonist MK-801 (0.03-0.3 mg/kg, i.p.) increased the response rate of mice trained under the discrete shuttle avoidance situa tion to a degree similar to the increase by methamphetamine (0.1-1 mg/kg, i.p.). The cholecystokinin-like decapeptide ceruletide significantly reduced the response-in creasing effect of MK-801 (0.1 mg/kg) at 0.001 pg/kg; however, only 10 pg/kg of ceruletide, which per se inhibited the response, attenuated that of methamphetamine (0.3 mg/kg). The coadministration of MK-801 (0.1 mg/kg) and methamphetamine (0.3 mg/kg) produced no potentiation of the effect, and almost the same effect was main tained even after the additional administration of ceruletide (0.1 ,ug/kg).

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Isolation and amino acid sequence of caerulein, the active decapeptide of the skin of Hyla caerulea

Cited by 199 publications

References 18 publications

OCCURRENCE OF CAERULEIN IN EXTRACTS OF THE SKIN OF HYLA CAERULEA AND OTHER AUSTRALIAN HYLIDS

OCCURRENCE OF CAERULEIN IN EXTRACTS OF THE SKIN OF HYLA CAERULEA AND OTHER AUSTRALIAN HYLIDS

The Endogenous Secretin in Chicken: Minor Physiological Role in Exocrine Pancreatic Secretion

Differential Antagonism of the Stimulant Effects of MK-801 and Methamphetamine by Ceruletide: Evaluation by Discrete Shuttle Avoidance Response in Mice.

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