Isolation and anti-inflammatory effect of astragalin synthesized by enzymatic hydrolysis of tea seed extract

Lee, Hyang‐Bok; Kim, Eun-Ki; Park, Sang-Jae; Bang, Sang-gu; Kim, Tae Gil; Chung, Dae-Won

doi:10.1002/jsfa.4457

Cited by 36 publications

(27 citation statements)

References 30 publications

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“…Several groups have confirmed that AG exhibits a number of biological properties, including anti-inflammatory, antioxidant, and anti-atopic dermatitis effects [11–14]. In addition, AG can attenuate lipopolysaccharide (LPS)-induced inflammatory responses by suppressing the NF-кB signaling pathway [15]. However, few studies have investigated the therapeutic potential of AG as a cancer therapy agent.…”

Section: Introductionmentioning

confidence: 99%

Astragalin-induced cell death is caspase-dependent and enhances the susceptibility of lung cancer cells to tumor necrosis factor by inhibiting the NF-κB pathway

et al. 2017

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Flavonoids are naturally occurring polyphenolic compounds and are among the most promising anticancer agents. Here, we demonstrate that the flavonoid astragalin (AG), also known as kaempferol-3-O-β-D-glucoside, induces cell death. This was prevented by the caspase inhibitors z-DEVD-FMK and z-LEHD-FMK. AG-induced cell death was associated with an increase in the Bax:Bcl-2 ratio and amplified by the inhibition of extracellular signal-regulated kinase (ERK)-1/2 and Akt signaling. Meanwhile, AG suppressed LPS-induced NF-κB activation. Additional studies revealed that AG inhibited tumor necrosis factor-alpha (TNFα)-induced NF-κB activity. AG also potentiated TNFα-induced apoptosis in A549 cells. Furthermore, using a mouse xenograft model, we demonstrated that AG suppressed tumor growth and induced cancer cell apoptosis in vivo. Taken together, these results suggest that AG may be a promising cancer therapeutic drug that warrants further investigation into its potential clinical applications.

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Section: Introductionmentioning

confidence: 99%

Astragalin-induced cell death is caspase-dependent and enhances the susceptibility of lung cancer cells to tumor necrosis factor by inhibiting the NF-κB pathway

et al. 2017

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“…From the flavonoid glycosides determined in the current study, astragalin (Lee et al, 2011), isoquercitrin (Rogerio et al, 2007), nicotiflorin (Soberon et al, 2010) and rutin (Lee et al, 2015), as well as chlorogenic acids (Liang and Kitts, 2016) have been previously stated as demonstrating anti-inflammatory activity.…”

Section: Anti-inflammatory Activitymentioning

confidence: 70%

Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago

Svobodová

Barros

Calhelha

et al. 2017

Industrial Crops and Products

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a b s t r a c tA wild variety of bitter melon Momordica charantia L. (Cucurbitaceae) has been used in bush medicine of Trinidad and Tobago for treatment of diabetes, inflammations and cancer. Despite many studies regarding the cultivated bitter melon, the wild variety has been poorly investigated. This study evaluates the biological activities of the ethanol/water extract of aerial parts and correlates these activities with the presence of phenolic compounds. The extract exhibited antioxidant activity in the four assays (DPPH, reducing power, ␤-carotene bleaching and TBARS). The key role of oxidative stress in inflammation and tumorigenesis was supported by the results of anti-inflammatory (inhibition of nitric oxide production) and cytotoxicity (human tumor cell lines, namely HeLa, HepG2, MCF-7, and NCI-H460) assays. In contrast, no toxicity was observed in non-tumor cells. In the antibacterial screening, clinical resistant isolates were significantly affected (MIC 50 = 10-0.625 g/mL), being Listeria monocytogenes the most susceptible. Three phenolic acids and eleven flavonol glycosides derivatives were identified, quercetin-3-O-pentosylhexoside being the most abundant.

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“…Astragalin has also been reported to have antioxidant (Choi et al, 2013) and anti-inflammatory (Lee et al, 2011) effects. Astragalin is considered to be ubiquitous in the plant kingdom, Note: Different small letters (a, b, c) in the same row and capital letters (A, B, C) in the same column represent significant differences between harvest time and cultivar, respectively, at p < 0.05.…”

Section: Flavonoidsmentioning

confidence: 99%

Influence of Harvest Time on Biologically Active Compounds and the Antioxidant Activity in Leaves of Mulberry Grown in Lithuania

Levickienė

Jarienė

Gajewski

et al. 2017

Not Bot Horti Agrobo

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The aim of this study was to establish the influence of harvest time on the contents of flavonoid compounds (rutin, isoquercetin, nicotiflorin, and astragalin) and chlorogenic acid, as well as the antiradical activity in white mulberry (Morus alba L.) leaves grown in Lithuania. Mulberry leaves contain a wide range of bioactive compounds, such as flavonoids and phenolic acids, which are responsible for beneficial effects on human health. Leaves from two mulberry cultivars were collected from July to September in 2015-2016. Quantitative determinations of four flavonoids and chlorogenic acid were conducted by HPLC method and antiradical activity using the 2.2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method. The results showed that the total flavonoid contents of mulberry leaves in the two cultivars ranged from 921.92 to 1512.02 mg 100 g −1 (dry matter). The highest accumulated rutin, nicotiflorin, and chlorogenic acid contents and the greatest antioxidant activity were found in the leaves of 'Plodovaja 3'. The bioactive compounds in the leaves of the mulberry cultivars varied over a period of time, where 'Turchanka' and 'Plodovaja 3' accumulated the highest total flavonoid contents in September and August, respectively. In both cultivars, the antiradical activity was highest in September. There were a very strong positive correlations between the antiradical activity as determined using the DPPH method and the chlorogenic acid contents (r = 0.887, p < 0.05) and the isoquercetin contents (r = 0.848, p < 0.05).

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Isolation and anti-inflammatory effect of astragalin synthesized by enzymatic hydrolysis of tea seed extract

Abstract: It was concluded that pure AS can be prepared by enzymatic partial hydrolysis of TSE and employed as an anti-inflammatory material. This is the first study to address the preparation of pure AS from natural sources.

Cited by 36 publications

References 30 publications

Astragalin-induced cell death is caspase-dependent and enhances the susceptibility of lung cancer cells to tumor necrosis factor by inhibiting the NF-κB pathway

Astragalin-induced cell death is caspase-dependent and enhances the susceptibility of lung cancer cells to tumor necrosis factor by inhibiting the NF-κB pathway

Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago

Influence of Harvest Time on Biologically Active Compounds and the Antioxidant Activity in Leaves of Mulberry Grown in Lithuania

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