Isolation and anticancer activity of quercetin from Acalypha indica L. against breast cancer cell lines MCF-7 and MDA-MB-231

Chekuri, Sudhakar; Vyshnava, Satyanarayana Swamy; Somisetti, Swarupa Lakshmi; Cheniya, Sai Bindu Karamthote; Gandu, Chakradhar; Anupalli, Roja Rani

doi:10.1007/s13205-023-03705-w

Cited by 11 publications

(1 citation statement)

References 68 publications

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“…Moreover, in a literature review with a similar perspective, the researchers discussed the issue, and presented ample evidence to support the efficacy of flavonoids on breast cancer [45], which is in alignment with our results. Moreover, Chekuri et al [46] showed that quercetin inhibited MCF-7 and MDA-MB-231 cells, as evaluated by apoptosis and cell cycle phase measurements. On the other hand, none of the tested bee pollen extracts showed toxic effects against a normal cell line (hFOB (human fetal osteoblastic)).…”

Section: Cell Linesmentioning

confidence: 99%

Differentiating between Monofloral Portuguese Bee Pollens Using Phenolic and Volatile Profiles and Their Impact on Bioactive Properties

Larbi,

Aylanc,

Rodríguez-Flores

et al. 2023

Molecules

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Nowadays, bee products are commended by consumers for their medicinal and dietary properties. This study aimed to differentiate between monofloral bee pollens originating from Portugal using phenolic and volatile profiles and investigate their antioxidant and cytotoxic activity. Total phenolic and flavonoid compounds were recorded between 2.9–35.8 mg GAE/g and 0.7–4.8 mg QE/g, respectively. The LC/DAD/ESI-MSn analytical results allowed us to identify and quantify a total of 72 compounds, including phenolic and phenylamide compounds, whereas GC-MS results revealed the presence of 49 different compounds, mostly ketones, aldehydes, esters, hydrocarbons, and terpenes. The highest DPPH• radical scavenging activity, EC50: 0.07 mg/mL, was recorded in the sample dominated by Castanae sp. pollen, whereas the Rubus sp. (1.59 mM Trolox/mg) and Cistaceae sp. (0.09 mg GAE/g) pollen species exhibited the highest antioxidant activity in ABTS•+ and reducing power assays, respectively. Regarding the anti-carcinogenic activity, only Carduus sp. showed remarkable cytotoxic potential against MCF-7.

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Section: Cell Linesmentioning

confidence: 99%