Isolation and antiviral activity of the gymnemic acids

Sinsheimer, Joseph E.; Rao, G. Sasibhushana; McIlhenny, Hugh M.; Smith, Robert V.; Maassab, Hunein F.; Cochran, Kenneth W.

doi:10.1007/bf02152834

Cited by 32 publications

(12 citation statements)

References 6 publications

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“…From the results obtained as virus yield, synergism was evaluated using the criteria reported by Spector et al (14). As shown in exerted activity against influenza A virus (18,19). Antiviral activities of glycyrrhizic acid (20,21) and glycyrrhizin (22) have been reported.…”

Section: Resultsmentioning

confidence: 96%

Inhibitory Activity of Soyasaponin II on Virus Replicationin vitro

Hayashi

Hiraoka

et al. 1997

Planta Med

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The antiviral activities of two saponins, soyasaponin I and II, isolated from soybean (Glycine max Merrill) were studied in vitro against herpes simplex virus type 1 (HSV-1). Soyasaponin II was more potent than soyasaponin I as shown by reduction of HSV-1 production. Soyasaponin II was also found to inhibit the replication of human cytomegalovirus, influenza virus, and human immunodeficiency virus type 1. The action was not due to inhibition of virus penetration and protein synthesis, but might involve a virucidal effect. When acyclovir and soyasaponin II were evaluated in combination for anti-HSV-1 activity, additive antiviral effects were observed for this virus.

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Section: Resultsmentioning

confidence: 96%

Inhibitory Activity of Soyasaponin II on Virus Replicationin vitro

Hayashi

Hiraoka

et al. 1997

Planta Med

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“…87 Several saponins, for example aescine from Aesculus hippocastanum, primula saponin from Primula veris, saikosaponin A from Bupleurum falcatum, theasaponin from Thea sinensis, and gymnemic acid from Gymnema sylvestre, showed antagonist activity against influenza A2 virus. 88,89 Arganine C, the saponin isolated from the fruit of Tieghemella heckelii Pierre ex A. Chev. (Sapotaceae), showed antiviral activity against HIV virus.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Exploring the possible use of saponin adjuvants in COVID-19 vaccine

Sharma

Palanisamy

Dhama

et al. 2020

Human Vaccines & Immunotherapeutics

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There is an urgent need for a safe, efficacious, and cost-effective vaccine for the coronavirus disease 2019 (COVID-19) pandemic caused by novel coronavirus strain, severe acute respiratory syndrome-2 (SARS-CoV-2). The protective immunity of certain types of vaccines can be enhanced by the addition of adjuvants. Many diverse classes of compounds have been identified as adjuvants, including mineral salts, microbial products, emulsions, saponins, cytokines, polymers, microparticles, and liposomes. Several saponins have been shown to stimulate both the Th1-type immune response and the production of cytotoxic T lymphocytes against endogenous antigens, making them very useful for subunit vaccines, especially those for intracellular pathogens. In this review, we discuss the structural characteristics, mechanisms of action, structure–activity relationship of saponins, biological activities, and use of saponins in various viral vaccines and their applicability to a SARS-CoV-2 vaccine.

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“…Gymnemic Acid is the potent antiviral compound with suf icient scienti ic studies has been reported since 1968 against in luenza (Sinsheimer et al, 1968). Recently, Vimalanathan et al studied the same compound against Human Corona virus, which showed greater activity against the SARS CoV with the concentration of 0.5 µg/ml (Vimalanathan et al, 2009).…”

Section: Gymnemasylvestrementioning

confidence: 99%

Treatments and Prophylactics for a Global Emergency Alert: COVID 19 using Allopathic and Indian Phytomedicine

Venkatesan¹,

Kothandan²,

Radhakrishnan³

et al. 2020

ijrps

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SARS CoV 2 (severe acute respiratory syndrome novel corona virus-2) to which the world paid the complete attention to face the Global Emergency Alert. COVID 19 was first identified in Wuhan, province in China on December, 2020. The virus was originated from the Bats and transmitted through other intermediary animals. There are around 12.7 lakhs reported cases and more than 69.4 thousands deaths (06/04/2020) which pave the way for having the health crises in the entire world’s population. The governing bodies of the various countries are quarantining their people to avoid the various stages of CoV spreading. Compared to the SARS CoV (severe acute respiratory syndrome coronavirus) and MERS CoV (Middle East respiratory syndrome coronavirus), the fatality rate was lower. But it provides the major impacts on elder population (fatality rate more than 40-50 %). Normal/ low white cell counts with elevated CRP (C-reactive protein ) severs as the laboratory findings for the SARS CoV 2 with the symptoms of cough, sneeze, difficulties in breathing and fever followed by ARDS (Acute respiratory distress syndrome) and multi organ dysfunction. By complete understanding of CoV 2 Pathogenesis, presently many drugs are repositioning to completely eradicate the COVID 19. So many drugs are under clinical trials in which the Hydroxychloroquine produces the greater effects on SARS CoV. Likewise many drugs are subjected to this mega clinical trial by repositioning the drugs. AYUSH recommends some of the prophylactics and dietary supplements for the COVID 19. This global emergency was not only for the researchers but also all professionals and their impact to the world’s developed and developing countries still unknown.

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Isolation and antiviral activity of the gymnemic acids

Cited by 32 publications

References 6 publications

Inhibitory Activity of Soyasaponin II on Virus Replicationin vitro

Inhibitory Activity of Soyasaponin II on Virus Replicationin vitro

Exploring the possible use of saponin adjuvants in COVID-19 vaccine

Treatments and Prophylactics for a Global Emergency Alert: COVID 19 using Allopathic and Indian Phytomedicine

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