Isolation and Biological Properties of Endogenous Baboon (Papio cynocephalus) Type C Viruses1

Heberling, R. L.; Kalter, S. S.; Barker, S. T.; Weislow, Owen S.

doi:10.1159/000399118

Comparative Leukemia Research 1975

DOI: 10.1159/000399118

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Isolation and Biological Properties of Endogenous Baboon (Papio cynocephalus) Type C Viruses1

R. L. Heberling¹,

S. S. Kalter²,

S. T. Barker³

et al.

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“…Type C baboon endogenous viruses (BaEV) have been isolated by cocultivation of baboon cells in vitro with cells of heterologous species; this has been necessary because homologous cells are generally nonpermissive for replication of BaEV and cultures of most baboon tissues do not produce the virus (3,9,16,17). Only a few examples of chronic or induced release of virus in baboon cell cultures have been reported (12; Lavelle and Foote, Abstr.…”

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confidence: 99%

Expression of baboon endogenous virus in exogenously infected baboon cells

Lavelle¹,

Foote²,

Heberling³

et al. 1979

J Virol

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Strains of low-passage, fetal diploid, baboon (Papio cynocephalus) fibroblasts were susceptible to exogenous infection with three independent isolates of baboon endogenous virus, as measured by an immunofluorescence assay specific for viral p28. Infectivity of the M7 strain of baboon endogenous virus for baboon cells of fetal skin muscle origin was equivalent to that for human and dog cells in that similar, linear, single-hit titration patterns were obtained. The assay for supernatant RNA-dependent DNA polymerase, however, showed that baboon cells produced only low levels of virus after infection compared with the production by heterologous cells. The results showed that baboon endogenous virus was capable of penetrating baboon cells and that viral genes were expressed in infected cells. Replication of complete infectious virus was restricted, however, indicating that in this primate system homologous cells differentially regulated the expression of viral genes.

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mentioning

confidence: 99%

Expression of baboon endogenous virus in exogenously infected baboon cells

Lavelle¹,

Foote²,

Heberling³

et al. 1979

J Virol

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Decreased colony forming ability of human cells persistently infected with baboon endogenous virus

Kamiya

Tanaka

Ogura

et al. 1983

Archives of Virology

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Plating efficiency (PE), i.e. colony forming ability, of primary human embryonic lung fibroblasts persistently infected with baboon endogenous virus (BaEV) decreased to less than 10 per cent of that of the uninfected cells. A line of human amnion (FL) cells showed a 55 per cent reduction of PE after the establishment of BaEV carrier state. No decrease of PE did occur as a result of BaEV persistent infection in a rhabdomyosarcoma cell line (A204) and in fibroblasts derived from adult human skin. This characteristic reduction of PE in the infected primary embryonic fibroblasts was completely abolished by cultivation of the cells with conditioned medium from confluent either virus-infected or uninfected culture.

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Isolation and Biological Properties of Endogenous Baboon (Papio cynocephalus) Type C Viruses1

Cited by 2 publications

References 0 publications

Expression of baboon endogenous virus in exogenously infected baboon cells

Expression of baboon endogenous virus in exogenously infected baboon cells

Decreased colony forming ability of human cells persistently infected with baboon endogenous virus

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