Isolation and Biological Properties of the Natural Flavonoids Pectolinarin and Pectolinarigenin—A Review

Abstract

Flavonoids are metabolites widely distributed in plants and commonly present in foods, such as fruits and vegetables. Pectolinarin, which belongs to the flavone subclass, has attracted considerable attention due to its presence in many medicinal plants. It has turned out to be a good biological agent especially due to its antioxidant, anti-inflammatory, antidiabetic, and antitumor activities, evaluated both in vitro and in vivo. Its aglycone, the metabolite pectolinarigenin, is also known for a series of biological properties including anti-inflammatory and antidiabetic effects. In the first overview on the two metabolites here presented, their collection, isolation and the results of their biological evaluation are reported.

Optimization of Ultrasound-Assisted Extraction via Sonotrode of Phenolic Compounds from Orange By-Products

“…With a molecular formula C 17 H 14 O 6 (peak 71) this compound has been assigned to pectolinarigenin according with Cheriet et al [ 76 ] who described it in several plants and fruits as oranges. However, this compound has been previously named in Citrus sinensis peel by Fayek et al [ 59 ] as dihydroxy-dimethoxyflavone, previously identified in Citrus reticulata peel by Yang et al [ 77 ].…”

In Search of Herbal Anti-SARS-Cov2 Compounds

“…Moreover, plants often contain a number of compounds, with different activities that can complement each other. Thus, Cirsium japonicum , popular in traditional Chinese medicine, contains pectolinarin and pectolinarigenin, which have antiviral and immunomodulatory effects, respectively ( Cheriet et al, 2020 ). Pectolinarigenin shows high suppressive immunomodulatory potency, including inhibitory activity of neutrophil phagocytes respiratory burst as well as T-cells proliferation ( Erukainure et al, 2017 ).…”

Natural Products and Their Derivatives with Antibacterial, Antioxidant and Anticancer Activities

“…The majority of natural products are produced from plants, and one of the largest groups of plant-derived products is flavonoids, as more than 13,000 plant flavonoids have been isolated and identified [ 1 ]. These plant-derived compounds have remarkable pharmaceutical and medical applications, particularly in preventing diseases.…”

“…Among plant flavonoids, pectolinarin and its aglycone, pectolinarigenin, are identified as the major constituents in many medicinal herbs around the world. A review on the isolation, pharmacological aspects and therapeutic potential of these two flavonoids was written by Cheriet et al [ 1 ], providing a comprehensive summary of our understanding of these secondary metabolites. Another widely distributed group of products in the plant kingdom is that of stilbenoids.…”