Isolation and characterisation of the monoterpenoid indole alkaloids of Aspidosperma pyrifolium

Araújo, João Xavier de; Antheaume, Cyril; Trindade, Roseane Cristina Prédes; Schmitt, Martine; Bourguignon, Jean‐Jacques; Santana, Antônio Euzébio Goulart

doi:10.1007/s11101-006-9044-y

Cited by 18 publications

(11 citation statements)

References 25 publications

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“…The present study was conducted to evaluate the protective ability of aqueous extract from the leaves of Aspidosperma pyrifolium against inflammation induced by carrageenan and Tityus serrulatus scorpion venom. Previous studies of chemical composition of A. pyrifolium reported the presence of alkaloids in the leaves and stem of this species [ 17 , 31 ]. However, in this approach, with the aid of HPLC-DAD and LC-DAD-MS analyses, the presence of flavonoids and phenolic acid were observed in aqueous extract of A. pyrifolium leaves.…”

Section: Discussionmentioning

confidence: 99%

“…The Apocynaceae family has considerable economic and medicinal importance [ 17 , 18 ]. Aspidosperma pyrifolium , popularly known as “pereiro”, mainly grows in the semi-arid northeastern region of Brazil [ 19 ], and has several applications in folk medicine, such as relief of benign prostatic hyperplasia, erectile dysfunction and inflammation [ 18 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Aspidosperma pyrifolium Has Anti-Inflammatory Properties: An Experimental Study in Mice with Peritonitis Induced by Tityus serrulatus Venom or Carrageenan

Lima

Bitencourt

Furtado

et al. 2017

IJMS

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Scorpions of the genus Tityus are responsible for the majority of envenomation in Brazil, the Tityus serrulatus species being the most common and dangerous in South America. In this approach, we have investigated the ability of the aqueous extract from the leaves of Aspidosperma pyrifolium in reducing carrageenan-induced inflammation and the inflammation induced by T. serrulatus envenomation in mice. We also evaluated the cytotoxic effects of this extract, using the 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl-2H-tetrazolium (MTT) assay and the results revealed that the extract is safe. Analysis by High Performance Liquid Chromatography coupled with Diode Array Detector (HPLC-DAD) and Liquid Chromatography Coupled with Mass Spectrometry with Diode Array Detection (LC-DAD-MS) showed one major chemical component, the flavonoid rutin and phenolics compounds. For in vivo studies in carrageenan-induced peritonitis model, mice received extracts, dexamethasone, rutin or saline, before administration of carrageenan. For venom-induced inflammation model, animals received T. serrulatus venom and were, simultaneously, treated with extracts, antivenom, rutin or saline. The extract and rutin showed a reduction in the cell migration into the peritoneal cavity, and in the same way the envenomated animals also showed reduction of edema, inflammatory cell infiltration and vasodilation in lungs. This is an original study revealing the potential action of A. pyrifolium against inflammation caused by Tityus serrulatus venom and carrageenan, revealing that this extract and its bioactive molecules, specifically rutin, may present potential anti-inflammatory application.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Aspidosperma pyrifolium Has Anti-Inflammatory Properties: An Experimental Study in Mice with Peritonitis Induced by Tityus serrulatus Venom or Carrageenan

Lima

Bitencourt

Furtado

et al. 2017

IJMS

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“…thoxypyrifoline, aspidofractinine and N-formylaspidofractinine [89]. We have identified in A. pyrifolium insecticidal [90], antibacterial [91] and hypotensive activities [92].…”

Section: Phytochemicals -Isolation Characterisation and Role In Humamentioning

confidence: 99%

“…Despite reports of low toxicity associated with the use of plants of the genus Aspidosperma [109,110,[117][118][119], some studies show a contrary position regarding the species A. pyrifolium [89,120]. In a study of the species A. pyrifolium cases of abortion in goats were reported due to ingestion of parts of the plants and when the ethanol extract of the leaves was administered to pregnant rats reduced fetal weight and maternal toxicity was observed, as well as hemolysis and toxicity test the front microcrustacean Artemia salina [120].…”

Section: Phytochemicals -Isolation Characterisation and Role In Humamentioning

confidence: 99%

Aspidosperma Terpenoid Alkaloids — Biosynthetic Origin, Chemical Synthesis and Importance

Aquino¹,

Aquino²,

OliveiraSantos³

et al. 2015

Phytochemicals - Isolation, Characterisation and Role in Human Health

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“…The toxic component of A . pyrifolium remains unknown, but the monoterpenoid indole alkaloids aspidofractinine, 15‐demethoxypyrifoline and N ‐formylaspidofractine have previously been identified in the plant (Araújo et al , ). Leaves of the plant were negative for the presence of isocupressic acid, a known abortifacient in pine needles (Riet‐Correa et al , ).…”

Section: Abortion‐inducing Plantsmentioning

confidence: 99%

A review of poisonous plants that cause reproductive failure and malformations in the ruminants of Brazil

Riet-Correa

Medeiros

Schild

2011

J of Applied Toxicology

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The objective of this review is to provide a report on toxic plants causing reproductive problems in ruminants in Brazil. Aspidosperma pyrifolium causes abortion or stillbirth in goats, as well as most likely in sheep and cattle, in the semiarid regions of Northeastern Brazil. Intoxications by Ateleia glazioveana, Tetrapterys acutifolia and T. multiglandulosa result in abortion and neonatal mortality in cattle and sheep, and the same signs have been experimentally observed in goats. These three plants can also cause cardiac fibrosis and a nervous disease with spongiosis of the central nervous system. Other plants known to cause abortion include Enterolobium contortisiliquum, E. gummiferum, Stryphnodendron coriaceum, S. obovatum and S. fissuratum. These plants can also cause digestive signs and photosensitization. Abortions have been reported in animals intoxicated by nitrates and nitrites as well. Infertility, abortions and the birth of weak offspring have been reported in animals intoxicated by plants containing swainsonine, including Ipomoea spp., Turbina cordata and Sida carpinifolia. Trifolium subterraneum causes estrogenism in cattle. Mimosa tenuiflora and, most likely, M. ophthalmocentra cause malformations and embryonic mortality in goats, sheep and cattle in the semiarid regions of Northeastern Brazil.

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Isolation and characterisation of the monoterpenoid indole alkaloids of Aspidosperma pyrifolium

Cited by 18 publications

References 25 publications

Aspidosperma pyrifolium Has Anti-Inflammatory Properties: An Experimental Study in Mice with Peritonitis Induced by Tityus serrulatus Venom or Carrageenan

Aspidosperma pyrifolium Has Anti-Inflammatory Properties: An Experimental Study in Mice with Peritonitis Induced by Tityus serrulatus Venom or Carrageenan

Aspidosperma Terpenoid Alkaloids — Biosynthetic Origin, Chemical Synthesis and Importance

A review of poisonous plants that cause reproductive failure and malformations in the ruminants of Brazil

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