1983
DOI: 10.1016/0378-1097(83)90264-1
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Isolation and characterization of a cholera-related enterotoxin from Salmonella typhimurium

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Cited by 15 publications
(16 citation statements)
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“…Whichever is the case, there is clearly an optimal bacterial phenotype since young log-phase cultures are more efficient elicitors of fluid secretion than organisms taken in late-log or stationary phase. We have not yet proved the existence of a CT-like enterotoxin, as demonstrated by Finkelstein et al (1983); but already, in the strains used in this study, we have shown the existence of a salmonella enterotoxin (Wallis et al, 1986a), and a CT-related antigen (Clarke et al, 1988) which may or may not be a CT-related toxin. The expression of this antigen is dependent on the culture medium and the time at which the culture is examined (Clarke et al, 1988;Qi et al, 1989).…”
Section: Discussionmentioning
confidence: 67%
“…Whichever is the case, there is clearly an optimal bacterial phenotype since young log-phase cultures are more efficient elicitors of fluid secretion than organisms taken in late-log or stationary phase. We have not yet proved the existence of a CT-like enterotoxin, as demonstrated by Finkelstein et al (1983); but already, in the strains used in this study, we have shown the existence of a salmonella enterotoxin (Wallis et al, 1986a), and a CT-related antigen (Clarke et al, 1988) which may or may not be a CT-related toxin. The expression of this antigen is dependent on the culture medium and the time at which the culture is examined (Clarke et al, 1988;Qi et al, 1989).…”
Section: Discussionmentioning
confidence: 67%
“…Enterotoxic activities of non-typhoid salmonellae have been reported by several groups of workers who have used various cell and animal tests. The properties of the enterotoxic entity are said to resemble those of cholera toxin (CT) (Sandefur and Peterson, 1977;Finkelstein et al, 1983), E. coli heat-stable toxin (ST) (Koupal and Deibel, 1975;Jiwa and Mansson, 1983), shiga toxin (ShiT) (O'Brien et al, 1982;Koo et al, 1984) and even a hybrid CT-ShiT (Ketyi et al, 1979). Extracts of strain W118 were tested for ShiT by Dr A. D. O'Brien (O'Brien et al, 1982) and again at our request and contained 20CD50 of ShiT/mg of protein; comparable extracts from Shigella dysenteriae type 1 contained 3 x lo5 CD50 of ShiT/mg of protein (1 CDso kills 50% of tissue-culture cells exposed).…”
Section: Introductionmentioning
confidence: 99%
“…Recently, we reported the discovery of nanH in the salmonellae (Vimr et (40), indicating the presence of a nan system. These observations may be pertinent to the recent discovery of choleralike toxin in the salmonellae (12,32), as they further suggest that NANase may function to increase toxin receptor density in susceptible hosts. We have since shown that NANase production in LT-2 is also modulated by sialic acid, suggesting that nanH expression may be regulated similarly to nanA and nanT in this species.…”
Section: Discussionmentioning
confidence: 77%