Isolation and characterization of a new polymorph of D‐sorbitol

Wang, Yanlei; Gao, Jia; Yin, Qiuxiang; Hao, Hongxun

doi:10.1002/crat.201100565

Cited by 9 publications

(4 citation statements)

References 14 publications

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“…Further, O-H bending vibrations can be identified at 1411–1415 cm −1 and C-OH stretching vibrations within 950 to 1150 cm −1 . These spectra and respective assignments [ 43 ] are concordant to others previously reported for glycerol [ 41 , 44 , 45 ] and sorbitol [ 38 , 41 , 46 , 47 ]. Given that glycerol and sorbitol are composed by the same functional groups (hydroxyls and alkyls), their pure spectra have overlapping bands ( Figure 3 a,b).…”

Section: Resultssupporting

confidence: 91%

Therapeutic Liquid Formulations Based on Low Transition Temperature Mixtures for the Incorporation of Anti-Inflammatory Drugs

2021

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Most nonsteroidal anti-inflammatory drugs (NSAIDs) present poor aqueous solubility, impairing their efficiency in physiological media. In this context, Low Transition Temperature Mixtures (LTTMs) are a promising platform to overcome drugs’ poor solubility, forming therapeutic liquid formulations. In this work, the LTTMs of citric acid:L-arginine:water (C:A:W) and glycerol:sorbitol (G:S) were studied in terms of their features and assessed in terms of their ability to increase the solubility of six NSAIDs in physiological media. The physicochemical properties of LTTMs were characterized by state-of-art techniques commonly used for these systems. The cytotoxicity of G:S was also evaluated in L929 mouse fibroblasts and the viscosity, polarity, and pH properties of the studied mixtures were related to the solubility of NSAIDs. The pH and polarity were the parameters that most influenced the drugs’ solubility. Ibuprofen, naproxen, ketoprofen, indomethacin, and flurbiprofen did not present any solubility improvement in the formulations tested. However, concentrated mixtures of C:A:W or G:S in the physiologic-mimicked media (PBS) rendered a celecoxib solubility 4 and 5 times higher than PBS, respectively. These therapeutic liquid formulations of celecoxib in C:A:W or G:S can be a promising tool to increase celecoxib’s therapeutic efficiency in local applications.

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Section: Resultssupporting

confidence: 91%

Therapeutic Liquid Formulations Based on Low Transition Temperature Mixtures for the Incorporation of Anti-Inflammatory Drugs

2021

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“…The s-PEDOT:PSS thin films with and without post water rinsing were further characterized by FTIR spectroscopy (Figure a,b). The absorption peak near 1050 cm –1 is the C–O stretching vibration of d -sorbitol, and the peak at around 3400 cm –1 is the O–H stretching vibration . These vibrations can be clearly observed in d -sorbitol and 6 wt % s-PEDOT:PSS without post water rinsing.…”

Section: Resultsmentioning

confidence: 92%

“…The absorption peak near 1050 cm −1 is the C−O stretching vibration of D-sorbitol, and the peak at around 3400 cm −1 is the O−H stretching vibration. 27 These vibrations can be clearly observed in D-sorbitol and 6 wt % s-PEDOT:PSS without post water rinsing. However, they almost disappear for 6 wt % s-PEDOT:PSS after rinsed with water.…”

Section: ■ Results and Discussionmentioning

confidence: 94%

Biocompatible Conductive Polymers with High Conductivity and High Stretchability

Zhang

Guan

et al. 2019

ACS Appl. Mater. Interfaces

174

133

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Stretchable electronic materials have drawn strong interest due to their important applications in areas such as bioelectronics, wearable devices, and soft robotics. The stretchable electrode is an integral unit of stretchable systems. Intrinsically c o n d u c t i v e p o l y m e r s s u c h a s p o l y ( 3 , 4ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) can have high mechanical flexibility and good biocompatibility. However, their electrical conductivity and mechanical stretchability should be greatly improved for its applications as the stretchable electrode. Here, we report highly conductive and highly stretchable PEDOT:PSS by incorporating biocompatible D-sorbitol. D-Sorbitol can serve as both the secondary dopant and plasticizer for PEDOT:PSS. It can not only significantly improve the conductivity but also the stretchability. D-Sorbitol-PEDOT:PSS (s-PEDOT:PSS) can have a conductivity of >1000 S/cm, and the conductivity could be maintained at a strain up to 60%. The resistance of s-PEDOT:PSS remains almost constant during repeated stretching−releasing cycles. The mechanism for the stretchability improvement by D-sorbitol is ascribed to the softening of PSSH chains. D-Sorbitol can position among the PSSH chains and thus destructs the hydrogen bonds among the PSSH chains. This makes the conformational change of the PSSH chains under stress become easy and thus increases the mechanical flexibility of PEDOT:PSS. This conductivity is the highest for biocompatible intrinsically conductive polymers with high stretchability.

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“…Polymorphs can have different solubilities, growth rates, stabilities, and melting points, to name a few differences. Eight different anhydrous polymorphs and one hydrate have been identified in literature with the crystalline melt being the least stable and the γ polymorph being the most stable (Nezzal et al., 2009; Wang, Gao, Yin & Hao, 2012; Mathlouthi, Benmessoud, & Roge, 2012). As the most stable, the γ polymorph of sorbitol, often called γ sorbitol, is typically what is desired in industrial manufacturing of sorbitol as well as in confectionery products (Du Ross, 1984; Nezzal et al., 2009).…”

Section: Introductionmentioning

confidence: 99%

Quantification of γ‐sorbitol crystal growth rate and solubility in the presence of mannitol and maltitol

DeJong

Hartel

2020

Journal of Food Science

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In many confectionery systems, an understanding of crystallization behavior is essential for proper control of product texture. While this knowledge is well developed in sucrose-based systems, there is little information on controlling crystallization in sugar-free systems, such as those formulated with sorbitol. By leveraging such advances in time domainnuclear magnetic resonance (TD-NMR) methodology, the impact of mannitol and maltitol on modulating sorbitol crystal growth in sugar-free systems. Binary and ternary systems of sorbitol mixed with mannitol, maltitol, or a mixture thereof were evaluated at total impurity addition levels of 10% and 20%. Polyol mixtures were dissolved in water, evaporated to 10% moisture, and mixed with γ sorbitol seed crystals to create a sugar-free fondant. Fondants were crystallized at 25°C, and crystal content was measured using TD-NMR over time. Crystal content increased rapidly at the start but quickly tapered off to a final asymptote indicating phase equilibrium. In all systems, the addition of impurities decreased the extent and rate of sorbitol crystallization, with mannitol having the greatest impact on rate. When both mannitol and maltitol were present as impurities, the rate of crystallization was reduced to a greater extent. At the highest level of mannitol, the final crystal content increased, presumably because mannitol also crystallized.

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Isolation and characterization of a new polymorph of D‐sorbitol

Cited by 9 publications

References 14 publications

Therapeutic Liquid Formulations Based on Low Transition Temperature Mixtures for the Incorporation of Anti-Inflammatory Drugs

Therapeutic Liquid Formulations Based on Low Transition Temperature Mixtures for the Incorporation of Anti-Inflammatory Drugs

Biocompatible Conductive Polymers with High Conductivity and High Stretchability

Quantification of γ‐sorbitol crystal growth rate and solubility in the presence of mannitol and maltitol

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