Isolation and characterization of a new type D retrovirus from the Asian primate, Presbytis obscurus (spectacled langur)

Todaro, George J.; Benveniste, Raoul Ė.; Sherr, Charles J.; Schlom, Jeffrey; Schidlovsky, G.; Stephenson, John

doi:10.1016/0042-6822(78)90231-3

Cited by 78 publications

(46 citation statements)

References 17 publications

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“…To date there have been six non-human primate species from which retroviruses have been isolated; these include the baboon, woolly monkey, and gibbon, from which type-C viruses have been isolated, and the three species described here, from which type-D viruses have been isolated. (8,32) have shown that the following viruses compete in an assay utilizing antisera to MPMV and the gp7O of the baboon virus: MPMV, baboon virus, langur virus, SMRV, and RD-1 14. That assay, therefore, appears to be detecting determinants shared by some type-C and type-D viruses.…”

Section: Discussionmentioning

confidence: 99%

“…We have recently shown that the squirrel monkey retrovirus (SMRV) is an endogenous virus of squirrel monkeys (10). Morphologically similar viruses from squirrel monkeys have also been isolated by Todaro et al (8). To date, little if any nucleic acid sequence homology has been detected between the RNA genomes of SMRV and MPMV (10), whereas some homology is observed between the RNA genomes of the Old World monkey isolates, MPMV and the langur virus (8).…”

mentioning

confidence: 98%

“…A virus similar to MPMV has recently been isolated from a spectacled langur (Presbytis obscurus) (8). When purified langur virus was used as competitor in the type-D interspecies assay, complete blocking was observed (Fig.…”

mentioning

confidence: 99%

“…The prototype virus of this group, the Mason-Pfizer monkey virus (MPMV), is transmitted in the rhesus (Macaca mulatta) population by a non-germ-line mechanism (6,7). A virus morphologically similar to MPMV has recently been isolated from a spectacled langur (Presbytis obscuris) and has been shown to be an endogenous virus of that species (8). Both the rhesus and langur are Old World monkeys.…”

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confidence: 99%

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Interspecies radioimmunoassay for the major structural proteins of primate type-D retroviruses.

Colcher¹,

Teramoto²,

Schlom³

1977

Proc. Natl. Acad. Sci. U.S.A.

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A competition radioimmunoassay has been developed in which type-D retroviruses from three primate species compete. The assay utilizes the major structural protein (36,000 daltons) of the endogenous squirrel monkey retrovirus and antisera directed against the major structural protein (27,000 daltons) of the Mason-Pfizer monkey virus isolated from rhesus monkeys. Purified preparations of both viruses grown in heterologous cells, as well as extracts of heterologous cells infected with squirrel monkey retrovirus or Mason-Pfizer monkey virus, compete completely in the assay. Addition of an endogenous virus of the langur monkey also results in complete blocking. No blocking in the assay is observed with type-C baboon viruses, woolly monkey virus, and gibbon virus. Various other type-C and type-B viruses also showed no reactivity. An interspecies assay has thus been developed that recognizes the type-D retroviruses from both Old World monkey (rhesus and langur) and New World monkey (squirrel) species.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 98%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Interspecies radioimmunoassay for the major structural proteins of primate type-D retroviruses.

Colcher¹,

Teramoto²,

Schlom³

1977

Proc. Natl. Acad. Sci. U.S.A.

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“…Genetically transmitted retroviruses have previously been isolated from both New World and Old World monkeys (1)(2)(3)(4)(5)(6)(7)(8)(9). These isolates have been classified as type C or type D viruses based on morphologic properties and can be subdivided into several distinct classes according to both antigenic and nucleic acid hybridization criteria (8,10).…”

mentioning

confidence: 99%

A new endogenous primate type C virus isolated from the Old World monkey Colobus polykomos.

Sherwin¹,

Todaro²

1979

Proc. Natl. Acad. Sci. U.S.A.

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A new, genetically transmitted retrovirus has been isolated from the Old World monkey Colobus polykomos. This virus, designated CPC-1, is readily transmitted to both feline and human cells in culture. Nucleic acid hybridization studies reveal that there are 50-70 copies of the CPC-1 genome in colobus cellular DNA. Related virogene sequences can be detected in the DNA of all other Old World monkeys, as well as in the DNA of at least one ape species, the chimpanzee, indicating that this virus has been genetically transmitted in primates for 30-40 million years. CPC-1 is partially related to the type C virus previously isolated from stumptail monkeys (MAC-1). These two viruses have nucleic acid sequence homology, antigenic crossreactivity in their major viral structural protein, and a very similar host range in vitro. CPC-1 and MAC-1 therefore belong to the same class of genetically transmitted primate type C viruses and, as such, represent the first example in primates of analogous endogenous retroviruses isolated from two distantly related species.

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Betaretroviruses

2009

Simian Virology

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Isolation and characterization of a new type D retrovirus from the Asian primate, Presbytis obscurus (spectacled langur)

Cited by 78 publications

References 17 publications

Interspecies radioimmunoassay for the major structural proteins of primate type-D retroviruses.

Interspecies radioimmunoassay for the major structural proteins of primate type-D retroviruses.

A new endogenous primate type C virus isolated from the Old World monkey Colobus polykomos.

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