Isolation and Characterization of a Papovavirus from Human Urine

Prevalence Rate and Age of Acquisition of Antibodies against JC Virus and BK Virus in Human Sera

“…It seems likely that these viruses are transmitted to individuals by urinary or salivary contamination among childhood contacts since antibodies are rapidly acquired during early childhood; urine was a suitable specimen for most isolations of BK virus (8,12,14,30,31,36) and, less frequently, JC virus (5, 16); and a possible association between acute respiratory illness and primary infection with BK virus has been suggested (14,18,38). In regard to pregnant women (7,27,34), the prevalence of antibody against BK virus and against JC virus was 70-90% and 55% respectively; a fourfold or greater increase in titer during pregnancy was demonstrated at higher frequency for BK virus than JC virus (5); and the occurrence of IgM antibodies during pregnancy was more frequent for BK virus than for JC virus (13).…”

Isolation of a variant of BK virus with altered restriction endonuclease pattern

“…After the initial isolation of BK virus by GARDNER et al (5) a number of human papovaviruses that are related to BK virus has been isolated (2,3,8,9, 10, 11,12,13,15,20,22,24) and a number of differences has been reported between the various isolates. LECATSAS et al (13) found immunological differences between the prototype BK virus strain and their isolate MG. W~IG~T et al (22) reported small differences in protein composition of four BKV-]ike isolates.…”

The human polyomavirus BK: Potential role in cancer

“…BKV and JCV are antigenically different from one another and from all other animal polyomaviruses although, cross‐reactions occur by using hyperimmune antisera. BKV, JCV, and simian virus 40 (SV40) share a minor, common antigenic determinant which is exposed on the surface of virions (Penney and Narayan, 1973; Takemoto and Mullarkey, 1973; Dougherty and DiStefano, 1974; Padgett and Walker, 1976; Jin and Gibson, 1996). BKV is ubiquitous in human populations worldwide (Padgett and Walker, 1976) except in some segregated populations living in isolated regions of Brazil, Paraguay, and Malaysia (Brown et al, 1975).…”