1983
DOI: 10.7164/antibiotics.36.1295
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Isolation and characterization of ancovenin,a new inhibitor of angiotensin I converting enzyme,produced by Actinomycetes.

Abstract: Ancovenin, an inhibitor of angiotensin I converting enzyme isolated from the culture broth of a Streptomyces species, is a dialysable peptide composed of sixteen amino acid residues containing unusual amino acids such as threo-;3-methyllanthionine, meso-lanthionine, and dehydroalanine. * In the preliminary tests , the IC50 value of ancovenin to rat lung ACE is 8.5 x 10-8 M, while the values of captopril, MK-422, and potentiator C, a peptidyl inhibitor, are 1.4X10-1m, 3.5x10-1m, and 5.6x10-7M, respectively.

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Cited by 75 publications
(31 citation statements)
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“…In addition, many nonlantibiotic bacteriocins, such as propionicin T1 (11), propionicin F (3), propionicin PLG-1 (29), propionicin SM1 (32), and jenseniin G (14), have been characterized from different species of Propionibacterium, an important genus of the Actinobacteria used in food fermentations. Lantibiotics were also characterized from different species of Streptomyces, such as ancovenin (22) and duramycins B and C (13). Recently, a novel lantibiotic compound, microbisporicin from the actinomycete Microbispora corallina, was also characterized (5,12), substantiating the propensity for lantibiotic production by different members of the Actinobacteria.…”
mentioning
confidence: 89%
“…In addition, many nonlantibiotic bacteriocins, such as propionicin T1 (11), propionicin F (3), propionicin PLG-1 (29), propionicin SM1 (32), and jenseniin G (14), have been characterized from different species of Propionibacterium, an important genus of the Actinobacteria used in food fermentations. Lantibiotics were also characterized from different species of Streptomyces, such as ancovenin (22) and duramycins B and C (13). Recently, a novel lantibiotic compound, microbisporicin from the actinomycete Microbispora corallina, was also characterized (5,12), substantiating the propensity for lantibiotic production by different members of the Actinobacteria.…”
mentioning
confidence: 89%
“…No. A647P-2 [28] pH 6.0. Deep-frozen cultures of the producing strain were used to inoculate agar discs and after inoculation for 12 h at 37°C transferred into conical flasks containing 100 ml medium consisting of meat extract 3.3%, malt extract 3.0%, Ca(OH)2 0.38%, pH 6.5.…”
Section: H -I~~~-a~~~-n H -C~~-~~-~~~~-~~~~-~~~~-n H -C H~-c O -N H -mentioning
confidence: 99%
“…Actinobacterial bacteriocins inhibit the growth of species related to the producer, such as michiganin A [13], although many of them possess a broad spectrum of inhibitory activity that includes non-related bacteria (microbisporicin), protozoans (thiostrepton), yeasts and fungi (cinnamycin) and viruses (labyrinthopeptin A1 and duramycin) [14][15][16][17][18]. In addition to antimicrobial activity, some actinobacterial bacteriocins and their semisynthetic derivatives also exhibit anti-inflammatory [19][20][21], anti-allergic [20], antitumour [22][23][24] and antinociceptive activities [25,26], and may also act in blood pressure regulation [19,27]. Some of these peptides have already found clinical applications, such as thiostrepton, a thiopeptide used in dermatologic ointment for veterinary use [28], and others are in stages of pre-clinical and clinical trials, such as NAI-107, NAI-112 [29] and lancovutide/duramycin (https://clinicaltrials.gov/ct2/show/study/ NCT00671736?term=Lancovutide&rank=1; accessed September 17,2016), which reinforces the great potential of practical application of bacteriocins produced by Actinobacteria.…”
Section: Bacteriocins Produced By Actinobacteriamentioning
confidence: 99%
“…Ancovenin and cinnamycin inhibit the activity of the angiotensin-converting enzyme, presenting a potential application in blood pressure regulation [19,27]. Cinnamycin and duramycin act as phospholipase A 2 (PLA 2 ) inhibitors [20,21].…”
Section: Cinnamycin Groupmentioning
confidence: 99%