Isolation and characterization of anti-inflammatory and analgesic compounds from Uapaca staudtii Pax (Phyllanthaceae) stem bark

Thomas, Paul S.; Essien, Emmanuel E.; Udoh, Anwanabasi E.; Archibong, Bright; Akpan, Ofonasaha; Etukudo, Emediong; Leo, Marinella De; Eseyin, Olorunfemi A.; Flamini, Guido; Ajibesin, K. K.

doi:10.1016/j.jep.2020.113737

Cited by 7 publications

(4 citation statements)

References 15 publications

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“…injection of 2 μg/5 μL of betulinic acid (61), after 7 days PSNL induction, significantly reverted mechanical allodynia 2 and 3 h after administration, in comparison with the vehicle group. Thomas et al confirmed the anti-inflammatory activity of betulinic acid (61), isolated from Uapaca staudtii Pax (Phyllanthaceae) ethanol extract, using fresh egg albumin-induced hind-paw and xyleneinduced ear edema in mice [112]. However, betulinic acid (61) shows poor water solubility and a short half-life, hence, it is not possible to use a systemic administration route.…”

Section: Quercetin and Kaempferolmentioning

confidence: 99%

From Plant to Chemistry: Sources of Antinociceptive Non-Opioid Active Principles for Medicinal Chemistry and Drug Design

Turnaturi,

Piana,

Spoto

et al. 2024

Molecules

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Pain is associated with many health problems and a reduced quality of life and has been a common reason for seeking medical attention. Several therapeutics are available on the market, although side effects, physical dependence, and abuse limit their use. As the process of pain transmission and modulation is regulated by different peripheral and central mechanisms and neurotransmitters, medicinal chemistry continues to study novel ligands and innovative approaches. Among them, natural products are known to be a rich source of lead compounds for drug discovery due to their chemical structural variety and different analgesic mechanisms. Numerous studies suggested that some chemicals from medicinal plants could be alternative options for pain relief and management. Previously, we conducted a literature search aimed at identifying natural products interacting either directly or indirectly with opioid receptors. In this review, instead, we have made an excursus including active ingredients derived from plants whose mechanism of action appears from the literature to be other than the modulation of the opioid system. These substances could, either by themselves or through synthetic and/or semi-synthetic derivatives, be investigated in order to improve their pharmacokinetic characteristics and could represent a valid alternative to the opioid approach to pain therapy. They could also be the basis for the study of new mechanisms of action in the approach to this complex and disabling pathology.

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Section: Quercetin and Kaempferolmentioning

confidence: 99%

From Plant to Chemistry: Sources of Antinociceptive Non-Opioid Active Principles for Medicinal Chemistry and Drug Design

Turnaturi,

Piana,

Spoto

et al. 2024

Molecules

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“…The xylene-induced ear swelling model was adapted from the method of Thomas et al (Thomas et al 2021) and changed a little. All mice were given the treatment specified in part 2.3.1 for seven days in a row.…”

Section: Xylene-induced Ear Swelling In Micementioning

confidence: 99%

Isolation and identification of anti-inflammatory and analgesic polysaccharides from Coix seed ( Coix lacryma-jobi L.var. Ma-yuen (Roman.) Stapf )

Sui

De-ping

2022

Natural Product Research

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Coix seed is a nutrient-rich food and traditional Chinese medicine with anti-inflammatory and analgesic properties. Polysaccharides from Coix seed have been rarely investigated for structure and activities. In this study, the analgesic and anti-inflammatory effects were investigated in vivo and in vitro. The results showed that Coix seed had a significant influence on reducing the number of writhing, increasing the pain threshold and alleviating the swelling degree caused by acute inflammation. Column chromatography was used to obtain two active compounds of Coix seed.Compound 1 was (1→6)-α-D-glucan with a molecular weight of 6.81×10 5 Da. The chemical connection of compound 2 was as follows: α-Frup (2→ [1)-α-Glcp (6] 5 →1)-α-Glcp (4→1)-α-Glcp, which was isolated in Coix seed for the first time. LPS-induced inflammation in RAW264.7 cells was well inhibited by compounds. These findings offered a preliminary investigation into the analgesic and anti-inflammatory properties of Coix seed, which may be helpful for application.

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“…It showed anti-inflammatory [ 163 ], antioxidant [ 163 ], neuroprotective [ 164 ], and anti-proliferative activities [ 165 ]. Protocatechuic acid exhibited significant (p < 0.05) anti-inflammatory (83% and 88% inhibition for egg-albumin induced and xylene induced oedema, respectively), analgesic (56% inhibition and 22 s of pain suppression for acetic acid-induced and hot plate-induced pain, respectively), and antioxidant effects (97% inhibition and absorbance of 2.516 at 100 μg/mL for DPPH and FRAP assay, respectively) in the models [ 166 ]. Extraction of leaf tissue from the golden-fleshed kiwifruit cultivar A. chinensis “Hort16A” expressing genotype-resistance against the fungus Botrytis cinerea , a new phenolic compound, 3,5-dihydroxy-2-(methoxycarbonylmethyl)phenyl 3,4-dihydroxybenzoate 278 was therefore obtained [ 167 ].…”

Section: Chemical Constituentsmentioning

confidence: 99%

Advances in Research on Chemical Constituents and Their Biological Activities of the Genus Actinidia

Liu

et al. 2021

Nat. Prod. Bioprospect.

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Kiwi, a fruit from plants of the genus Actinidia, is one of the famous fruits with thousand years of edible history. In the past twenty years, a great deal of research has been done on the chemical constituents of the Actinidia species. A large number of secondary metabolites including triterpenoids, flavonoids, phenols, etc. have been identified from differents parts of Actinidia plants, which exhibited significant in vitro and in vivo pharmacological activities including anticancer, anti-inflammatory, neuroprotective, anti-oxidative, anti-bacterial, and anti-diabetic activities. In order to fully understand the chemical components and biological activities of Actinidia plants, and to improve their further research, development and utilization, this review summarizes the compounds extracted from different parts of Actinidia plants since 1959 to 2020, classifies the types of constituents, reports on the pharmacological activities of relative compounds and medicinal potentials.

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Isolation and characterization of anti-inflammatory and analgesic compounds from Uapaca staudtii Pax (Phyllanthaceae) stem bark

Cited by 7 publications

References 15 publications

From Plant to Chemistry: Sources of Antinociceptive Non-Opioid Active Principles for Medicinal Chemistry and Drug Design

From Plant to Chemistry: Sources of Antinociceptive Non-Opioid Active Principles for Medicinal Chemistry and Drug Design

Isolation and identification of anti-inflammatory and analgesic polysaccharides from Coix seed ( Coix lacryma-jobi L.var. Ma-yuen (Roman.) Stapf )

Advances in Research on Chemical Constituents and Their Biological Activities of the Genus Actinidia

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