Isolation and Characterization of Antithrombin Peptides from the Saliva of Malaysian Leeches

Asrih, Mohamed; Uddin, Abm Helal; Ghawi, Abbas Mohammad

doi:10.4314/tjpr.v13i4.10

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…5 Modern medicine has found use for Leech therapy in a wide array of diseases and conditions such as CVD, reconstructive and microsurgery, malignancy, DM, infectious diseases, hearing abnormalities, arthritis and musculoskeletal pain. 5 …”

Section: Discussionmentioning

confidence: 99%

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Leech Induced Pyoderma Gangrenosum in an Ulcerative Colitis Patient: A Case Report

Sadeghi¹,

Navabakhsh²,

Vahedi³

2015

Middle East J Dig Dis

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Pyoderma gangrenosum (PG) is a painful skin lesion that results from excessive inflammatory response to a host of traumatic, inflammatory, or neoplastic processes in susceptible individuals. A clear pathogenetic mechanism as well as an exhaustive list of potential triggers for PG is yet to be fully characterized. This case documents the occurrence of pyoderma gangrenosum following leech-therapy in a patient who is a known case of ulcerative colitis and it deserves attention because leeches have been part of medical armamentarium since ancient times and have re-emerged in the last century relying on their ancient charm and modern research revealing potential benefits of several bioactive substances in their saliva.

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Section: Discussionmentioning

confidence: 99%

“…5 Hereby, we present a case of unjustified leech therapy for ulcerative colitis triggering several PG lesions at leech bite sites. …”

Section: Introductionmentioning

confidence: 95%

Leech Induced Pyoderma Gangrenosum in an Ulcerative Colitis Patient: A Case Report

Sadeghi¹,

Navabakhsh²,

Vahedi³

2015

Middle East J Dig Dis

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Comparative Transcriptomic Analyses of Three Species ofPlacobdella(Rhynchobdellida: Glossiphoniidae) Confirms a Single Origin of Blood Feeding in Leeches

Siddall

Brugler

Kvist

2016

Journal of Parasitology

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One of the recalcitrant questions regarding the evolutionary history of clitellate annelids involves the feeding preference of the common ancestor of extant rhynchobdellid (proboscis bearing) and arhynchobdellid (jaw bearing) leeches. Whereas early evidence, based on morphological data, pointed towards independent acquisitions of blood feeding in the 2 orders, molecular-based phylogenetic data suggest that the ancestor of modern leeches was a sanguivore. Here, we use a comparative transcriptomic approach in order to increase our understanding of the diversity of anticoagulation factors for 3 species of the genus Placobdella, for which comparative data have been lacking, and inspect these in light of archetypal anticoagulant data for both arhynchobdellid and other rhynchobdellid species. Notwithstanding the varying levels of host specificity displayed by the 3 different species of Placobdella, transcriptomic profiles with respect to anticoagulation factors were largely similar -this despite the fact that Placobdella kwetlumye only retains a single pair of salivary glands, as opposed to the 2 pairs more common in the genus. Results show that 9 different anticoagulant proteins and an additional 5 putative antihemostasis proteins are expressed in salivary secretions of the 3 species. In particular, an ortholog of the archetypal, single-copy, anticoagulant hirudin (not previously available as comparative data for rhynchobdellids) is present in at least 2 of 3 species examined, corroborating the notion of a single origin of blood feeding in the ancestral leech.

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Isolation and Characterization of Antithrombin Peptides from the Saliva of Malaysian Leeches

Cited by 2 publications

References 17 publications

Leech Induced Pyoderma Gangrenosum in an Ulcerative Colitis Patient: A Case Report

Leech Induced Pyoderma Gangrenosum in an Ulcerative Colitis Patient: A Case Report

Comparative Transcriptomic Analyses of Three Species ofPlacobdella(Rhynchobdellida: Glossiphoniidae) Confirms a Single Origin of Blood Feeding in Leeches

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