Isolation and characterization of cefotaxime resistant Escherichia coli from household floors in rural Bangladesh

Tabassum, Tahani; Hossain, Md. Sakib; Ercumen, Ayse; Benjamin-Chung, Jade; Abedin, Md. Foysal; Rahman, Mahbubur; Jahan, Farjana; Haque, Munima; Mahmud, Zahid Hayat

doi:10.1016/j.heliyon.2024.e34367

Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e34367

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Isolation and characterization of cefotaxime resistant Escherichia coli from household floors in rural Bangladesh

Tahani Tabassum,

Md. Sakib Hossain,

Ayse Ercumen

et al.

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2024

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Cited by 1 publication

References 69 publications

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Pathogens and Antimicrobial Resistance Genes in Household Environments: A Study of Soil Floors and Cow Dung in Rural Bangladesh

Nguyen,

Ratnasiri,

Heitmann

et al. 2024

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In low- and middle-income countries, living in homes with soil floors and animal cohabitation may expose children to fecal organisms, increasing risk of enteric and antimicrobial-resistant infections. Our objective was to understand whether cow cohabitation in homes with soil floors in rural Bangladesh contributed to the presence and diversity of potential pathogens and antimicrobial resistance genes (ARGs) in the home. In 10 randomly selected households in rural Sirajganj District, we sampled floor soil and cow dung, which is commonly used as sealant in soil floors. We extracted DNA and performed shotgun metagenomic sequencing to explore potential pathogens and ARGs in each sample type. We detected 6 potential pathogens in soil only, 49 pathogens in cow dung only, and 167 pathogens in both soil and cow dung. Pathogen species with relative abundances >5% in both soil floors and cow dung from the same households includedE. coli(N=8 households),Salmonella enterica(N=6),Klebsiella pneumoniae(N=2), andPseudomonas aeruginosa(N=1). Cow dung exhibited modestly higher pathogen genus richness compared to soil floors (Wilcoxon signed-rank test p=0.002). Using Bray-Curtis dissimilarity, pathogen species community composition differed between floors and cow dung (PERMANOVA p<0.001). All soil floors and cow dung samples contained ARGs against antibiotic classes including sulfonamides, rifamycin, aminoglycosides, lincosamides, and tetracycline. Paired floor and cow dung samples shared ARGs against rifamycin. Our findings support the development of interventions to reduce soil and animal feces exposure in rural, low-income settings.

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Pathogens and Antimicrobial Resistance Genes in Household Environments: A Study of Soil Floors and Cow Dung in Rural Bangladesh

Nguyen,

Ratnasiri,

Heitmann

et al. 2024

Preprint

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Isolation and characterization of cefotaxime resistant Escherichia coli from household floors in rural Bangladesh

Cited by 1 publication

References 69 publications

Pathogens and Antimicrobial Resistance Genes in Household Environments: A Study of Soil Floors and Cow Dung in Rural Bangladesh

Pathogens and Antimicrobial Resistance Genes in Household Environments: A Study of Soil Floors and Cow Dung in Rural Bangladesh

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