Isolation and characterization of horse α2-macroglobulin protease inhibitor

Pellegrini, Antonio; Zweifel, Hans-Rudolf; Fellenberg, R. von

doi:10.1016/0020-711x(83)90036-8

Cited by 7 publications

(1 citation statement)

References 16 publications

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“…One alpha macroglobulin molecule can bind to and remove 1 or 2 molecules of proteinase. 7 Alpha macroglobulins have been identified and studied in a variety of species other than humans, including the rat, 8 mouse, 9 dog, 10 pig, 11 cow, 12 horse, 13,14 and many others. [15][16][17][18][19] In the dog, 2 alpha macroglobulins have been identified.…”

Section: Alpha Macroglobulinsmentioning

confidence: 99%

An Overview of Proteinase Inhibitors

Hibbetts

Hines

Williams

1999

Veterinary Internal Medicne

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Proteinase inhibitors are proteins in the body that regulate the catalytic activity of proteinases. They are important in a large variety of physiologic processes including coagulation, digestion, tumor metastasis and immunity. Proteinase inhibitors are categorized as either nonspecific proteinase inhibitors or class-specific proteinase inhibitors. Nonspecific proteinase inhibitors are comprised soley of the alpha macroglobulins, most notably alpha2-macroglobulin. Class-specific proteinase inhibitors are subcategorized as serine proteinase inhibitors, aspartic proteinase inhibitors, metalloproteinase inhibitors, and cysteine proteinase inhibitors. Each subcategory is made up of numerous inhibitors. As the roles of individual proteinase inhibitors are determined, the therapeutic use of natural and synthetic proteinase inhibitors is also being investigated. The purpose of this article is to review the history and classification of proteinase inhibitors and their relevance to veterinary medicine.

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