Isolation and Characterization of Human Natural Killer Cell Subsets

Cooper, Megan A.; Caligiuri, Michael A.

doi:10.1002/0471142735.im0734s60

Cited by 22 publications

(17 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Normally, NK cells in the peripheral blood of healthy subjects have the phenotype 90% CD16 + and 10% CD16 - . The CD16 + phenotype is associated with activation and cytotoxicity, while the CD16 - cells release cytokines and are not cytotoxic [102]. In the PF of EOC patients, however, this ratio shifts to 60% CD16 + and 40% CD16 - .…”

Section: Immune Evasionmentioning

confidence: 99%

The detection, treatment, and biology of epithelial ovarian cancer

et al. 2010

View full text Add to dashboard Cite

Ovarian cancer is particularly insidious in nature. Its ability to go undetected until late stages coupled with its non-descript signs and symptoms make it the seventh leading cause of cancer related deaths in women. Additionally, the lack of sensitive diagnostic tools and resistance to widely accepted chemotherapy regimens make ovarian cancer devastating to patients and families and frustrating to medical practitioners and researchers. Here, we provide an in-depth review of the theories describing the origin of ovarian cancer, molecular factors that influence its growth and development, and standard methods for detection and treatment. Special emphasis is focused on interactions between ovarian tumors and the innate and adaptive immune system and attempts that are currently underway to devise novel immunotherapeutic approaches for the treatment of ovarian tumors.

show abstract

Section: Immune Evasionmentioning

confidence: 99%

The detection, treatment, and biology of epithelial ovarian cancer

et al. 2010

View full text Add to dashboard Cite

show abstract

“…In general, cytotoxic activity is associated with CD56 Dim pNKs and cytokine production with CD56 Bright pNKs(12, 13). However, CD56 Dim pNK cells are also capable of cytokine production and CD56 Bright pNKs may acquire cytotoxic capacity upon cytokine induced activation(14-16). …”

Section: Introductionmentioning

confidence: 99%

Conversion of Peripheral Blood NK Cells to a Decidual NK-like Phenotype by a Cocktail of Defined Factors

Cerdeira

Rajakumar

Royle

et al. 2013

The Journal of Immunology

169

172

View full text Add to dashboard Cite

Natural killer (NK) cells that populate the decidua are important regulators of normal placentation. In contrast to peripheral blood NK (pNK) cells, decidual NK cells (dNK) lack cytotoxicity, secrete pro-angiogenic factors and regulate trophoblast invasion. Here we show that exposure to a combination of hypoxia, transforming growth factor beta 1, and a demethylating agent, results in NK cells that express Killer cell Immunoglobulin like Receptors, the dNK cell markers CD9 and CD49a, and dNK pattern of chemokine receptors. These cells secrete vascular endothelial growth factor, a potent pro-angiogenic molecule, display reduced cytotoxicity and promote invasion of human trophoblast cell lines. These findings have potential therapeutic applications for placental disorders associated with altered NK cell biology.

show abstract

“…These soluble forms are increased in a variety of tumors and may serve as a tumor evasion mechanism [106] . According to the frequency of CD56 expression (dim or bright) and the presence or absence of CD16, NK cells can be divided into two subsets: CD56 bright CD16 neg (produces cytokines) and CD56 dim CD16 pos (cytotoxic) [107] . The density of NK cells in the peripheral blood of patients with HCC positively correlated with survival and prognosis similar to many of the other cell lines already mentioned [108] .…”

Section: Natural Killer Cellsmentioning

confidence: 99%