Isolation and characterization of limonoate and nomilinoate A-ring lactones

Zukas, Audrius A.; Breksa, Andrew P.; Manners, Gary D.

doi:10.1016/j.phytochem.2004.08.016

Cited by 20 publications

(17 citation statements)

References 17 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…ESIMS m/z: [M+H] + 471.1. This compound exhibited similar spectroscopic data ( 1 H and 13 C NMR) to published values (Ng et al, 1987;Zukas et al, 2004).…”

Section: Methodssupporting

confidence: 77%

Modulation of P‐glycoprotein activity by acridones and coumarins from Citrus sinensis

Bayet

Fazio

Darbour

et al. 2007

Phytotherapy Research

View full text Add to dashboard Cite

Bioguided fractionation of the roots of Citrus sinensis (Rutaceae) led to the isolation and identification of five coumarins, namely, clausarin, suberosin, poncitrin, xanthyletin and thamnosmonin, seven acridones, namely, acrimarine B, 2-methoxycitpressine I, citpressine I, buntanine, acrimarine E, honyumine and acrimarine C, and one terpenoid, namely, limonin. Among these compounds, clausarin, 2-methoxycitpressine I and acrimarine E inhibited P-glycoprotein-mediated drug efflux in K562/R7 human leukemic cells over-expressing P-glycoprotein.

show abstract

“…ESIMS m/z: [M+H] + 471.1. This compound exhibited similar spectroscopic data ( 1 H and 13 C NMR) to published values (Ng et al, 1987;Zukas et al, 2004).…”

Section: Methodssupporting

confidence: 77%

Modulation of P‐glycoprotein activity by acridones and coumarins from Citrus sinensis

Bayet

Fazio

Darbour

et al. 2007

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…These mass spectrometric techniques allow positive identification of limonoids in complex matrices. Zukas et al [16] reported the isolation and identification of two metabolites from young Chandler pummelo seedlings. It includes the purification of extracts by column chromatography and preparative HPLC to obtain limonoate A-ring lactone and nomilinoate A-ring lactone.…”

Section: Discussionmentioning

confidence: 99%

“…A modified solid-phase extraction procedure was used for limonin analysis [16]. The C18 Sep-Pak cartridge was preconditioned by first passing 6 ml of MeOH and water successively for 10 min.…”

Section: Sample Preparationmentioning

confidence: 99%

An improved HPLC method for the analysis of citrus limonoids in culture media

Tian

Miller

Jayaprakasha

2007

Journal of Chromatography B

View full text Add to dashboard Cite

“…1 In Citrus (Rutaceae), limonoids are prominent secondary metabolites that occur in high concentration as aglycones and glucosides. 2 The limonoids from Meliaceae are more complex with very high degree of oxidation and rearrangement exhibited in the parent limonoid structure and exhibited a range of potentially useful biological properties, such as insect antifeedant, antifungal activity, antimalarial, cytotoxic and growth-regulating activities, which have attracted much attention in natural products research. 3e5 The genus Toona (Meliaceae) is mainly distributed in tropical Asia and Africa, while four species and six varieties are distributed in China.…”

Section: Introductionmentioning

confidence: 99%