Isolation and characterization of multidrug-resistant Leclercia species from animal clinical case

Abstract

Significance and Impact of the Study: Leclercia adecarboxylata is a rarely reported human pathogen. We report here the case from bovine suffering from respiratory distress; the sample yielded Leclercia species as polymicrobial culture. The isolate was found to be multidrug resistant and evidenced for uncertain clinical relevance and could act as hidden source of public health hazard. The limited literature available on this organism is reviewed, and the potential implications of findings are discussed. To the best of our knowledge, this is the first report of isolation and characterization of multidrug-resistant Leclercia species from animal clinical case from India. AbstractLeclercia adecarboxylata, a Gram-negative bacillus of family Enterobacteriaceae, is an uncommonly identified pathogen isolated from environmental and clinical specimens. Most of the human infections are polymicrobial and commonly occur in immunocompromised hosts, although nosocomial infections in immunocompetent hosts have been documented. Here, we describe the case of isolation of Leclercia species as polymicrobial infection from bovine suffering from respiratory distress in Chhattisgarh state of India. The isolates were identified by their phenotypes, 16S rDNA sequencing and MALDI-TOF-MS. The isolate was found to be resistant to aminoglycosides and fluoroquinolone antibiotics and intermediate resistant to cephalosporins and evidenced for uncertain clinical relevance and could act as hidden source of public health hazard.

Migration of retrobulbar wooden foreign body between diagnostic imaging and surgical extraction in a German shepherd dog

“…It has been identified in a cow with a polymicrobial infection that succumbed to respiratory distress. 16 It has also been reported in an Antillean manatee blood culture, a bull shark oral cavity, a milk sample from a cow with mastitis, and a hen's eggshell surface. [17][18][19][20] Of those reports, the other clinically ill animal was the Antillean manatee.…”

“…To the authors’ knowledge, there are no reports of L. adecarboxylata infection in dogs. It has been identified in a cow with a polymicrobial infection that succumbed to respiratory distress . It has also been reported in an Antillean manatee blood culture, a bull shark oral cavity, a milk sample from a cow with mastitis, and a hen's eggshell surface .…”

Seltene Superinfektion bei einem COVID-19-Patienten – Eine Chronologie

“…Darüber hinaus gehört es zur Darmflora. In der Regel bestehen keine ausgeprägten Antibiotikaresistenzen, wobei auch schon resistente Stämme beschrieben worden sind [ 11 ].

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Genome sequencing and analysis of plant growth-promoting attributes from Leclercia adecarboxylata

“…Leclercia adecarboxylata, a member of the Enterobacteriaceae family, is a motile, aerobic, omnipresent Gram-negative bacterium. Infections by L. adecarboxylata in humans are scarcely reported, being considered an opportunistic pathogen (Kashani et al, 2014;Hoyos-Mallecot et al, 2017;Choudhary et al, 2018). This strain was first described and named Escherichia adecarboxylata by Leclerc (1962), and, later received the generic name Leclercia from Tamura et al, (1986).…”

“…This strain was first described and named Escherichia adecarboxylata by Leclerc (1962), and, later received the generic name Leclercia from Tamura et al, (1986). It was phenotypically differentiated by biochemical and DNA hybridization assays from other Enterobacteriaceae species (Choudhary et al, 2018). Recently, Hoyos-Mallecot et al (2017) published the draft genome of L. adecarboxylata strain harboring an NDM1 (Multidrug-resistant New Delhi metallo-β-lactamase 1) gene.…”