Isolation and characterization of natural and modified seed gum

Shukla, Ajay Kumar; Bishnoi, Ram Singh; Kumar, Mukesh; Jain, C. L.

doi:10.31024/ajpp.2019.5.2.27

Cited by 7 publications

(4 citation statements)

References 9 publications

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“…Moreover, Nayak et al also reported that hydrophilic FSM also binds with water to form viscous gel-structure, which barricades the pores on the surface of polymeric matrix [76] . Retardation of drug release from polymer matrix might be the synergistic effect of both viscosity and gel forming properties of FSM, which also corroborated with various earlier findings [48,[77][78][79] .…”

Section: Able 2: Percent Weight Loss Of 5-fu Sa Fsm Pm Dpm and Bfsupporting

confidence: 90%

Development and Characterization of Colon-targeting 5-Fluorouracil Multiparticulate Beads

Sarangi¹,

Rao²,

Parcha³

et al. 2020

Indian J Pharm Sci

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This investigation is related to the development and optimization of multiparticulate beads of fenugreek seed mucilage-sodium alginate containing 5-flurouracil through ionotropic gelation technique using 3 2 full factorial design generated with Design-Expert® Version11 software. The beads were developed using CaCl 2 as the crosslinking agent. The effect of ratio of fenugreek seed mucilage and sodium alginate blend and concentration of CaCl 2 on the drug encapsulation efficiency, bead size and percent cumulative drug release in 6 h was optimized by 3 2 factorial design. The beads were also characterized using field emission scanning electron microscopy, Fourier-transform infrared spectroscopy and thermal analysis. The percent drug encapsulation efficiency of all these beads was within the range of 43.91 to 85.39 % with an in vitro drug release of 33.92 to 39.23 % in 6 h. The optimized batches of beads were coated with Eudragit S100 (5, 10 and 15 % w/v) to facilitate colon targeting in a prominent way. The in vitro drug release from the coated beads (P3) in various colonic fluids followed zero-order pattern with erosion mechanism in 18 h. The average size of these beads was within the range of 895 to 1021 µm. The optimized fenugreek seed mucilage-alginate beads containing 5-flurouracil showed significant drug permeability over a prolonged period in an ex vivo permeability study through goat colon. The results indicated successful colon targeting of 5-flurouracil multiparticulate beads developed using polymeric blends containing sodium alginate and fenugreek seed mucilage in an appropriate ratio.

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Section: Able 2: Percent Weight Loss Of 5-fu Sa Fsm Pm Dpm and Bfsupporting

confidence: 90%

Development and Characterization of Colon-targeting 5-Fluorouracil Multiparticulate Beads

Sarangi¹,

Rao²,

Parcha³

et al. 2020

Indian J Pharm Sci

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“…[ 7 , 8 ] HAGE-101912 showed proton pump inhibitory activity in both ex vivo and in vivo models, which may be because it contains a substantial concentration of polyphenols and flavonoids, which are known to exhibit significant proton pump inhibitory activity. [ 7 , 18 ]…”

Section: Discussion and C Onclusionmentioning

confidence: 99%

Herbal Combination ‘HAGE-101912’ Ameliorates Gastroesophageal Reflux Disease in Rats

Azeemuddin,

Narendra,

Mallappa

et al. 2023

Journal of Pharmacy and Bioallied Sciences

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Background: Gastroesophageal reflux disease (GERD) is a chronic, relapsing disorder. In this era of modern and fast-track lifestyle and food habits, the incidence of GERD is rapidly increasing. Currently, proton pump inhibitors (PPIs) are the primary choice of treatment. However, the associated side effects and a high relapse rate give rise to the need to explore alternative therapies. Objective: The study aimed to evaluate HAGE-101912, an herbal combination, in different experimental models of GERD. Methods: Antacid activity was assessed based on H+/K+ATPase inhibitory activity of parietal cells using artificial gastric juice. Tonic contraction of the lower esophageal sphincter (LES) was evaluated using an AD Instrument. A GERD model of the pylorus and fundus ligation (preventive and curative models) in rats was selected to assess the efficacy of HAGE-101912 at a dose of 250 mg/kg body weight, and various parameters such as the gastric pH, gastric volume, total acidity, gross esophageal ulcer index, and histopathological changes were evaluated. The prokinetic activity was assessed using the phenol red method. Results: HAGE-101912 increased the acid-neutralizing capacity (P < 0.001), decreased H+/K+ATPase activity (P < 0.01), and increased the contraction of the LES. In the preventive model, HAGE-101912 significantly reduced the gastric acid volume (P < 0.01), total acidity (P < 0.001), and gross esophageal ulcer index (P < 0.01); increased the gastric acid pH (P < 0.01); and protected the esophageal epithelium. In addition, HAGE-101912 increased gastric emptying and gastrointestinal transit through its prokinetic activity (P < 0.05). Conclusion: HAGE-101912 has a beneficial effect in GERD as it effectively inhibits the H+/K+ATPase, increases the gastric pH, restores the LES function, protects the esophageal epithelium, and increases gastric emptying and transit.

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“…Gum Extraction from Samanea saman Seeds (11,12,13): Pods were dried in the oven at a temperature of 60°C for two days. Seeds were separated from pods and powdered separately.…”

Section: Methodsmentioning

confidence: 99%

Design and Development of Oral Mucoadhesive Drug Delivery System Based onNatural Polymer

Baste¹,

Basarkar²,

Gangurde³

et al. 2022

ECS Trans.

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This research paper explains the isolation of gum from the seeds of Samanea saman. Mucoadhesive tablets of Valsartan were formulated using novel gum of Samanea saman as a mucoadhesive polymer and Instamodel 41 as a release retardant. The formulation parameters like the concentration of Samanea saman gum and Instamodel 41 were optimized by using design expert software by constructing response surface graph, contour, and desirability graph. A relationship between variables was developed by constructing a polynomial equation using a quadratic and linear model. The optimized tablet formulation shows mucoadhesive strength 4635.65 Dynes/cm2 and Ex vivo Residence Time 382 min and complete drug release within 12 hours. In the ANOVA model F value, 292.58 for Mucoadhesive strength of tablet and 19.59 for t100% implies that the model is significant. Korsmeyer-Peppas model, suggests anomalous transport of drug release. Stability study suggests that optimized formulation is stable at the accelerated condition of temperature and humidity.

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Isolation and characterization of natural and modified seed gum

Cited by 7 publications

References 9 publications

Development and Characterization of Colon-targeting 5-Fluorouracil Multiparticulate Beads

Development and Characterization of Colon-targeting 5-Fluorouracil Multiparticulate Beads

Herbal Combination ‘HAGE-101912’ Ameliorates Gastroesophageal Reflux Disease in Rats

Design and Development of Oral Mucoadhesive Drug Delivery System Based onNatural Polymer

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