Isolation and characterization of new lactam compounds that inhibit lung and colon cancer cells from adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) bran

Lee, Ming-Yi; Lin, Hsiao‐Yun; Cheng, Faiwen; Chiang, Wenchang; Kuo, Yueh‐Hsiung

doi:10.1016/j.fct.2008.01.033

Cited by 107 publications

(80 citation statements)

References 22 publications

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“…In previous studies, flavonoids were reported to show antimicrobial (Cushnie & Lamb, 2006, anti-allergic (Chen et al, 2010), anti-inflammatory (Seo et al, 2000), and anticarcinogenic (Lee et al, 2008) activities. Until 2004, it was suggested Lamb, 2005, 2011) that their antibacterial efficacy was dependent upon cytoplasmic membrane damage by perforation (Ikigai et al, 1993), inhibition of nucleic acid synthesis (Mori et al, 1987) and disruption of energy metabolism due to NADH-cytochrome c reductase inhibition (Haraguchi et al, 1998).…”

mentioning

confidence: 99%

Antimycobacterial Activity Some Different Lamiaceae Plant Extracts Containing Flavonoids and Other Phenolic Compounds

Aşkun¹,

Tümen²,

Satıl³

et al. 2012

Understanding Tuberculosis - New Approaches to Fighting Against Drug Resistance

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confidence: 99%

Antimycobacterial Activity Some Different Lamiaceae Plant Extracts Containing Flavonoids and Other Phenolic Compounds

Aşkun¹,

Tümen²,

Satıl³

et al. 2012

Understanding Tuberculosis - New Approaches to Fighting Against Drug Resistance

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“…Secara fitokimia, jali mengandung 4-ketopinoresinol; alpha-coixin; alpha-sitosterol; betasitosterol; coicin; coixan A; coixan B; coixan C; coixenolide; coixlactam; coixol; coixspirolactam A; coixspirolactam B; coixspirolactam C; palmitic acid; stearic acid; oleic acid; linoleic acid; alkohol coniferyl alcohol; ferulic acid; gamma-sitosterol; glukosa; metil dioksindol-3-asetat; myuenolide; palmatate; phytin; kalium klorida, stearat, stigmasterol; syringic acid; syringaresinol; vitamin B1; dan peracetylated yang terbentuk dari glukosa, maltosa, maltotriosa, maltotetraose, dan maltopentaose (Bao et al 2005;Chang et al 2003;Chang et al 2006;Check dan K'Ombut 1995;Chung et al 2010;Dalimartha 2008;Hsia et al 2007;Hsia et al 2006;Kim et al 2004;Koh et al 2009;Kuo et al 2002;Lee et al 2008;Otsuka et al 1988;Shih et al 2004;Sugimoto et al 2001;Yang et al 2008).…”

Section: Potensi Dan Pemanfaatan Coix Lacryma-jobi Lunclassified

Jali (Coix lacryma-jobi L.): Biji, perkecambahan, dan potensinya

Irawanto

Lestari

Hendrian

2017

Prosiding Seminar Nasional Masyarakat Biodiversitas Indonesia

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Abstrak. Irawanto R, Lestari DA, Hendrian R. 2017. Jali (Coix lacryma-jobi L.): Biji, perkecambahan,. Tumbuhan jali (Coix lacryma-jobi L.) termasuk dalam famili Poaceae. Jenis ini secara alami ditemukan di daerah lahan basah (wetland) di tepian sungai/riparian, sehingga jali tergolong tumbuhan akuatik emergent, dimana salah satu koleksi Kebun Raya Purwodadi yang menarik adalah koleksi tumbuhan akuatik. Di sisi lain, daerah riparian/perairan sungai yang merupakan habitat C. lacryma-jobi L. seringkali terkena dampak pencemaran akibat berbagai aktivitas manusia. Pencemaran oleh limbah cair dari pertanian, domestik, perkotaan, bahkan industri, dapat merusak ekosistem perairan dan menganggu kesehatan manusia. Jali biasanya tumbuh liar dan belum banyak diketahui potensinya. Meskipun sangat jarang dimanfaatkan, beberapa penelitian merekomendasikan C. lacryma-jobi L. untuk dimanfaatkan dalam fitoteknologi pengolahan limbah dengan sistem constructed wetland. Fitoteknologi merupakan konsep yang memusatkan peran tumbuhan sebagai teknologi alami untuk mengatasi permasalahan lingkungan. Pengunaan jali dalam fitoteknologi sangat sesuai untuk negara berkembang karena sederhana, mudah, dan murah serta berpotensi untuk dikembangkan dalam skala besar. Oleh karena itu, penelitian mengenai perbanyakan (biji dan perkecambahan) jenis ini serta potensinya dalam fitoteknologi lingkungan perlu dilakukan. Penelitian dilakukan pada bulan Maret sampai Juni 2014 di rumah kaca Teknik Lingkungan -ITS dengan material biji C. lacryma-jobi L. dari Kebun Raya Purwodadi -LIPI. Hasil penelitian menunjukkan biji jali bersifat ortodok-rekalsitran, berkecambah sekitar 1-2 minggu dengan fase perkecambahan sekitar 1 bulan. Bibit jali berumur 1-3 bulan membutuhkan naungan dan air yang cukup. Bibit jali dikatakan dewasa apabila sudah berumur di atas 90 hari (>3 bulan) berumur 90 hst (hari setelah tanam) sekitar 3 bulan memiliki 3-10 helai daun, 1-4 ruas pada batang, dan tinggi rata-rata 30,5 cm. Kata kunci: Coix lacryma-jobi L., fitoteknologi, Kebun Raya PurwodadiAbstract. Irawanto R, Lestari DA, Hendrian R. 2017. Jali (Coix lacryma-jobi L.): Seeds, germination, and its potential. Pros Sem Nas Masy Biodiv Indon 3: 147-153. Jali (Coix lacryma-jobi L.) belongs to Poaceae family. This plant is naturally found in wetlands areas on the banks of the river / riparian. That Jali classified as emergent aquatic plants, where one of the Purwodadi Botanic Garden interesting collections is aquatic plants collection. On the other hand, the riparian area/river waters that are the habitat of Jali. often affected by pollution due to various human activities. Pollution by wastewater from agricultural, domestic, urban, industrial and even, can damage aquatic ecosystems and disrupt human health. Jali usually grows wild and has not been known potential. Although very rarely used, some studies recommend Jali. phytotechnology to be utilized in wastewater treatment with constructed wetland system. Phytotechnology is a concept that addresses the role of plants as natural technolo...

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“…ma-yuen) and showed that Coix seed extracts and these 3 substances has hypoglycemic effects in mice (Lu, Wu, Dong, & Li, 2009;Lu, Li, & Dong, 2008;Takahashi, Konno, & Hikino, 1986). Lee, Lin, Cheng, Chiang, & Kuo (2008) studied the effect of Coix stem extract and 5 lactam compounds separated from Coix stem extract by using Methanol (MeOH) on tumor cell inhibition. The experiments were conducted on A549 cell -human lung cancer cells; H-29 cellscolorectal cancer cell, etc.…”

Section: Impact Of Nitrogen Management On the Triolein Content In Coimentioning

confidence: 99%

“…Coix seed is a tonic, able to give a good results either to adults or children. It is used as a cure for milk supply for breast-feeding women (Lee, Lin, Cheng, Chiang, & Kuo, 2008;Lợi, 2006). Recently, studies that were conducted domestically and internationally showed that Coix really helps lowering the level of blood sugar and able to fight against cancer (Huang, Chiang, Yao, & Chiang W., 2005;Kim et al, 2004;Li, Chen, Lin, Chiang, & Shih, 2011;Takahashi, Konno, & Hikino, 1986).…”

Section: Introductionmentioning

confidence: 99%

EFFECT OF DOSE FERTILIZER AND CULTIVARS TO THE ACTIVE COMPOUND GLYCERYL TRIOLEATE OF Coix lacryma-jobi L.

Nghiem

Jiang²,

Shen³

et al. 2016

Agrivita.J.Agr.Sci

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In order to provide a method for quality control of glyceryl trioleate in Coix lacryma-jobi L., this paper focused on differentiating the glyceryl trioleate compound in 14 cultivars and effect of nitrogen on glyceryl trioleate in Coix seed by clustering of High Performance Liquid Chromatography (HPLC). This research was carried out to find a variety that has active glyceryl trioleate with the highest content and to investigate the effect of nitrogen to the active ingredients of glyceryl trioleate in Coix lacryma-jobi L. and its effect in Coix lacryma-jobi L. treatment. The standard regressive curve equation of glyceryl trioleate obtained by using HPLC was: Y = (7.10 6 ) X-495293, R² = 0.9997. The average reproducible experiment result of glyceryl trioleate is 0.097, RSD (relative standard deviation) is 1.95%; recovery rate is 97.69% and RSD is 0.89%. The experiment measured the glyceryl trioleate content of 14 varieties of Coix lacryma-jobi L using Qianyin #1 (C14). The result showed that fertilizer combination N10F2 (4:1:2:3) produced the highest glyceryl trioleate content in Coix lacryma-jobi L. Thus, nitrogen that applied in the fertilizer for 150kg ha -1 and the ratio of pre plant application including seedbed application, tillering application and earing application were optimized at 4:1:2:3 ratio.

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Isolation and characterization of new lactam compounds that inhibit lung and colon cancer cells from adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) bran

Cited by 107 publications

References 22 publications

Antimycobacterial Activity Some Different Lamiaceae Plant Extracts Containing Flavonoids and Other Phenolic Compounds

Antimycobacterial Activity Some Different Lamiaceae Plant Extracts Containing Flavonoids and Other Phenolic Compounds

Jali (Coix lacryma-jobi L.): Biji, perkecambahan, dan potensinya

EFFECT OF DOSE FERTILIZER AND CULTIVARS TO THE ACTIVE COMPOUND GLYCERYL TRIOLEATE OF Coix lacryma-jobi L.

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