Isolation and characterization of new limonoid glycosides from Citrus unshiu peels

Cytotoxic effects of peel extracts from Citrus limon and Citrus sinensis

“…In table 2 the mitotic indexes are given for control and for each Citrus species. It is evident Cytotoxic activities of some limonoids from the plants of the order Rutales have been reported before (Poulose et al 2005;Ö zmen and Sü mer 2004;Salehzadeh et al 2003;Sawabe et al 1999;Tada et al 1999;Cohen et al 1996;Ahn et al 1994). In conformity to these reports Citrus limon and Citrus sinensis peel extracts contains antimitotic substances.…”

“…Some of the most exciting applications of limonoids and their derivatives are their use in the treatments of cancers. Limonin and nomilin are limonoids that have been shown succesful in treatments on human tumor cell lines (Poulose et al 2005;Sawabe et al 1999;Tada et al 1999;Cohen et al 1996;Ahn et al 1994).…”

An insight into the role of citrus bioactives in modulation of colon cancer

“…The limonoids are chiefly present in seeds of citrus species such as Citrus sudachi (Nakagawa, Duan, & Takaishi, 2001), C. reticulate (Khalil, Maatooq, & El Sayed, 2003) in high concentration. However, peels (Citrus unshiu) have also been reported to possess these in significant amounts (Sawabe et al, 1999). On an average, orange, grapefruits and lemon juice contain 320, 190 and 80 mg/ml of limonoid glucosides, respectively (Miller, Porter, Binnie, Guo, & Hasegawa, 2004).…”

Citrus Limonoids: Analysis, Bioactivity, and Biomedical Prospects

“…Limonin glucoside (12), nomilin glucoside (13), and other limonoid glucosides have been obtained chromatographically from polar extracts of defatted citrus seeds (23) and structurally characterized (48,(55)(56)(57)(58)(59)(60)(61). The characterized limonoid glucosides are mono-glucosylated mono-or dicarboxylic acid derivatives of A-and D-ring limonoid aglycones.…”