Isolation and characterization of phospholipase A2, from Agkistrodon bilineatus (common cantil) venom

Nikai, Toshiaki; Komori, Yumiko; Satoru, Yagihashi; Ohara, A.; Ohizumi, Yasushi; Sugihara, Hisayoshi

doi:10.1016/0020-711x(93)90243-8

Cited by 7 publications

(1 citation statement)

References 19 publications

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“…Akihito had reported that the maternal microbiome has a great impact on the development of the offspring's immune system. The offspring of high fiber diet fed mice exhibited higher autoimmune regulator (Aire) expression, a transcription factor expressed in the thymic microenvironment, suggesting SCFAs promote thymic Treg differentiation through increased Aire expression [54].…”

Section: Plos Onementioning

confidence: 99%

Inulin alleviates offspring asthma by altering maternal intestinal microbiome composition to increase short-chain fatty acids

et al. 2023

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Technically, symptom of offspring asthma is also closely reliant on its maternal high-fiber diet as well as the intestinal microbiome. Fruits and vegetables are abundant in inulin, and this naturally soluble dietary fiber is endowed with a potential value on offspring asthma control through the maternal intake, but the mechanism now remains less studied. In this study, rats were given with inulin-included drinking water, whereas in normal group rats were allowed with normal water. Afterwards, we analyzed both the formations of the offspring intestinal microbiome ahead of asthma model establishment and of the maternal intestinal microbiome through high throughput sequence and the short-chain fatty acids (SCFAs) by metabolomic analysis. Subsequently, lung inflammation indexes were detected by Elisa, and the expression of short-chain fatty acid receptors (GPR41, GPR43) in the offspring of asthma models were evaluated through qPCR assay. Inulin intake resulted in altered maternal intestinal microbiome composition, with a significant increase in SCFAs-producing bacteria (mainly Bifidobacterium), attenuating the asthmatic inflammatory response in the offspring. Meanwhile, inulin intake during pregnancy modulates the composition of the intestinal microbiome of the offspring, and this alteration appears before the onset of asthma, hence, there should be further studies onto the impacts of offspring’s intestinal microbiome on asthma procession.

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Section: Plos Onementioning

confidence: 99%