Isolation and characterization of sodium 2-fluoroacetate from Mascagnia rigida using chromatography and infrared spectroscopy

Cunha, Luciana Castro da; Pípole, Fernando; Carvalho, Luciana Retz de; Lago, João Henrique G.; Górniak, Silvana Lima

doi:10.1016/j.toxicon.2012.04.346

Cited by 11 publications

(3 citation statements)

References 14 publications

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“…Sodium fluoroacetate also occurs naturally in several plant species, and it has been extensively described in toxic plants in South Africa, Australia, and Brazil. 2,6 However, it has not been found in plants in the United States. The source of compound 1080 in this case could not be determined, although according to the referring veterinarian (N.E.E.…”

Section: Discussionmentioning

confidence: 99%

An Outbreak of Sodium Fluoroacetate (1080) Intoxication in Selenium- and Copper-Deficient Sheep in California

et al. 2013

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Sodium fluoroacetate is an organofluorine compound toxic to mammals, insects, and birds, currently registered for use only in livestock protection collars as a predacide in some North American states, with restricted use in California. A flock of 445 lambs and ewes in California were moved into a native pasture on a municipal refuse disposal site. Within 24 hours, 14 ewes were found dead, and the remaining sheep were moved off the site. Both ewes and lambs exhibited disoriented running, followed by apparent blindness, weakness, ataxia, coma, and death. Over the next 4 days, 63 ewes and 80 lambs died with a peak at 3 days after grazing the suspect pasture (157/445, 35% mortality). Two dead 4-month-old lambs and 2 ewes were submitted to the California Animal Health and Food Safety laboratory for necropsy. Grossly, there were bilateral diffuse pulmonary congestion and edema, hydrothorax and hydropericardium with fibrin clots, and multifocally extensive areas of epicardial petechiae, ecchymoses, and pallor. In 1 ewe, there was regional caudodorsal pulmonary hemorrhage and intraluminal tracheal clotted blood. Microscopically in all cases, there was multifocal acute myocardial degeneration and necrosis with nonsuppurative pleocellular myocarditis. Sodium fluoroacetate was detected in kidney from a lamb and a ewe at 27.5 and 12.5 parts per billion, respectively. All sheep were selenium deficient, and concurrent copper deficiency was diagnosed in 3. The pathological and toxicological findings were consistent with 1080 poisoning, possibly exacerbated by micronutrient deficiency. This outbreak raised an alert about the use of restricted products with potential lethal effect in animals in California.

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Section: Discussionmentioning

confidence: 99%

An Outbreak of Sodium Fluoroacetate (1080) Intoxication in Selenium- and Copper-Deficient Sheep in California

et al. 2013

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“…A maioria dessas plantas contem monofl uoroacetato se sódio (MFA) (OLIVEIRA, 1963;KREBS et al, 1994;CUNHA et al, 2012;LEE et al, 2012). Essa substância não foi pesquisada em P. juruana, P. grandifl ora, P. elegans e F. japurensis, no entanto, a semelhança do quadro clínico-patológico entre todas as intoxicações por ingestão dessas plantas sugere que o princípio ativo dessas espécies também seja o MFA.…”

Section: Introductionunclassified

Intoxicação por Amorimia spp. em ruminantes

2013

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RESUMO No Brasil, um dos grupos mais importantes de plantas tóxicas é o das que causam morte súbita associada ao exercício. Integram esse grupo, plantas das famílias INTRODUÇÃOUm dos mais importantes grupos de plantas tóxicas no Brasil é o das que causam morte súbita associada ao exercício, que tem como principal característica a manifestação de sinais clínicos, quando os animais são movimentados. Integram esse grupo plantas das famílias Rubiaceae, Bignoniaceae

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“…Mascagnia), [57,59] Gastrolobium grandiflorum,[60] G. parviforum (formerly Oxylobium parviforum), [49,61] Spondianthus preussii [62] and Cyamopsis tetragonolobus. [63] Altogether, the known FA producing plants account for more than 40 species.…”

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confidence: 99%

Natural production of fluorinated compounds and biotechnological prospects of the fluorinase enzyme

Carvalho

Oliveira

2017

Critical Reviews in Biotechnology

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Fluorinated compounds are finding increasing uses in several applications. They are employed in almost all areas of modern society. These compounds are all produced by chemical synthesis and their abundance highly contrasts with fluorinated molecules of natural origin. To date, only some plants and a handful of actinomycetes species are known to produce a small number of fluorinated compounds that include fluoroacetate (FA), some ω-fluorinated fatty acids, nucleocidin, 4-fluorothreonine (4-FT), and the more recently identified (2R3S4S)-5-fluoro-2,3,4-trihydroxypentanoic acid. This largely differs from other naturally produced halogenated compounds, which totals more than 5000. The mechanisms underlying biological fluorination have been uncovered after discovering the first actinomycete species, Streptomyces cattleya, that is capable of producing FA and 4-FT, and a fluorinase has been identified as the enzyme responsible for the formation of the C-F bond. The discovery of this enzyme has opened new perspectives for the biotechnological production of fluorinated compounds and many advancements have been achieved in its application mainly as a biocatalyst for the synthesis of [F]-labeled radiotracers for medical imaging. Natural fluorinated compounds may also be derived from abiogenic sources, such as volcanoes and rocks, though their concentrations and production mechanisms are not well known. This review provides an outlook of what is currently known about fluorinated compounds with natural origin. The paucity of these compounds and the biological mechanisms responsible for their production are addressed. Due to its relevance, special emphasis is given to the discovery, characterization and biotechnological potential of the unique fluorinase enzyme.

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Isolation and characterization of sodium 2-fluoroacetate from Mascagnia rigida using chromatography and infrared spectroscopy

Cited by 11 publications

References 14 publications

An Outbreak of Sodium Fluoroacetate (1080) Intoxication in Selenium- and Copper-Deficient Sheep in California

An Outbreak of Sodium Fluoroacetate (1080) Intoxication in Selenium- and Copper-Deficient Sheep in California

Intoxicação por Amorimia spp. em ruminantes

Natural production of fluorinated compounds and biotechnological prospects of the fluorinase enzyme

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