Isolation and Characterization ofLRP6,a Novel Member of the Low Density Lipoprotein Receptor Gene Family

Brown, S. D.; Twells, Rebecca C.J.; Hey, P.; Cox, Roger D.; Levy, ER; Soderman, Avery R.; Metzker, Michael L.; Caskey, C. Thomas; Todd, John A.; Hess, J. Fred

doi:10.1006/bbrc.1998.9061

Cited by 188 publications

(136 citation statements)

References 33 publications

Supporting

Mentioning

134

Contrasting

Unclassified

Order By: Relevance

“…We identified seven distinct candidate transcriptional units, including ETV6, LRP6, BCL-G and MKP-7 that were characterised previously. 13,22,24,25 LOH1CR1, LOH2CR12 and LOH3CR12 are three novel genes characterized in this study.…”

Section: Discussionmentioning

confidence: 71%

“…LRP6 possesses two transcripts of 6 and 11 kb. 13 Using the same reasoning, it is clear that the 3' end of clusters Hs.23672, which includes the coding sequence of LRP6, and Hs.41269, containing over 90 ESTs, correspond to the 3' end of the short and long transcripts, respectively. All the other identified transcribed sequences, with the exception of LOH2CR12, were characterised by at least two different mRNA species by Northern hybridisation (Figure 3) suggesting the presence of alternative splicing or alternative usage of termination sites.…”

Section: Alternative Terminationmentioning

confidence: 94%

“…No other putative transcriptional units were present on the corresponding BAC clone RPCI11 ± 180M15 (data not shown). Two of the clusters corresponded to the ETV6 22 and LRP6 13 genes that were previously characterised in detail and mapped to this region 13,22 and as such will not be further discussed in this section.…”

Section: Transcription Map Of the Chromosome 12p12 Locusmentioning

confidence: 99%

“…11,12 This region was shown to contain two known genes, LRP6 and ETV6. LRP6 encodes a member of the LDL receptor family 13 that was recently shown to act as the WNT coreceptor. 14 ± 16 However Baens et al 10 failed to reveal any inactivating mutations in leukaemia patients.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A detailed transcriptional map of the chromosome 12p12 tumour suppressor locus

2002

View full text Add to dashboard Cite

Loss of heterozygosity of the short arm of chromosome 12 is a frequent event in a wide range of haematological malignancies and solid tumours. In previous studies, the shortest commonly deleted region was delimited to a 750-kb interval, defined by the markers D12S89 and D12S358, in pre-B acute lymphoblastic leukaemia patients, suggesting the presence of a tumour suppressor locus. Here we report the construction of a transcriptional map that integrates the data obtained by genomic sequence analysis, EST database search, comparative analysis and exon amplification. We identified seven putative transcriptional units as well as six pseudogenes. Four of these candidate genes were already known: ETV6, encoding an ets-like transcription factor, LRP6, a member of the LDL receptor gene family, BCL-G, a recently identified pro-apoptotic gene and MKP-7, encoding a new member of the dual-specificity phosphatase family. The products encoded by the three new genes identified in this study, LOH1CR12, LOH2CR12 and LOH3CR12, have no clear homology to known proteins. The gene predictions were all confirmed by expression analysis using RT ± PCR and Northern blot. This transcriptional map is a crucial step toward the identification of the tumour suppressor gene at 12p12.

show abstract

Section: Discussionmentioning

confidence: 71%

Section: Alternative Terminationmentioning

confidence: 94%

Section: Transcription Map Of the Chromosome 12p12 Locusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A detailed transcriptional map of the chromosome 12p12 tumour suppressor locus

2002

View full text Add to dashboard Cite

show abstract

“…Extracellular Wnt molecules bind to Fz seven-pass transmembrane receptors and to low-density lipoprotein receptor-related proteins (LRP5 or LRP6) to form a ternary complex [35][36][37][38]. This receptor complex induces the phosphorylation of Dishevelled (Dsh).…”

Section: The Canonical Wnt Signaling Pathwaymentioning

confidence: 99%

Wnt signaling: multiple functions in neural development

Ille

Sommer

2005

CMLS, Cell. Mol. Life Sci.

View full text Add to dashboard Cite

Abstract. Wnt signaling has proven to be essential for neural development at various stages and across species. Wnts are involved in morphogenesis and patterning, and their proliferation-promoting role is a key function in stem cell maintenance and the expansion of progenitor pools. Moreover, Wnt signaling is involved in differentiation CMLS, Cell. Mol. Life Sci. 62 (2005) 1100-1108 1420-682X/05/101100-09 DOI 10.1007/s00018-005-4552-2 © Birkhäuser Verlag, Basel, 2005 CMLS Cellular and Molecular Life Sciencesprocesses and lineage decision events during both central and peripheral nervous system development. Additionally, several reports point to a role of Wnt signaling in axon guidance and neurite outgrowth. This article reviews and consolidates the existing evidence for the functions of Wnt signaling in neural development.

show abstract

Wnt Signaling at the Membrane

Davidson

Niehrs²

2014

WNT Signaling in Development and Disease

View full text Add to dashboard Cite

Isolation and Characterization ofLRP6,a Novel Member of the Low Density Lipoprotein Receptor Gene Family

Cited by 188 publications

References 33 publications

A detailed transcriptional map of the chromosome 12p12 tumour suppressor locus

A detailed transcriptional map of the chromosome 12p12 tumour suppressor locus

Wnt signaling: multiple functions in neural development

Wnt Signaling at the Membrane

Contact Info

Product

Resources

About