Isolation and Hypoglycemic Activity of Arborans A and B, Glycans of<i>Aloe arborescens</i>var.<i>natalensis</i>Leaves

Hara, Hiroshi; Takahashi, Michiko; Murakami, Masaya; Chohachikonno,; Mirin, Yoshiaki; Karikura, Masami; Hayashi, Teruaki

doi:10.3109/13880208609060897

Cited by 40 publications

(22 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1), leading us to suppose that their mechanisms of action are different. Our results agree with Beppu et al, (1993) who reported that the activity of glibenclamide was weaker than that of A. arborescens juice powder and also support the claimed hypoglycaemic activity of various Aloe extracts (Ghannam et al, 1986;Hikino et al, 1986;Ajabnoor, 1990;Beppu et al, 1993;. The fact that Aloe leaf gel extract showed a hyperglycaemic effect in NIDDM rats can explain the negative results of some investigations in which the aqueous extract of the whole leaf was used (Mossa, 1985;Roman-Ramos, 1981).…”

Section: Discussionsupporting

confidence: 77%

“…Aloe species have been used for centuries for their laxative, antiinflammatory, immunostimulant, antiseptic (Capasso et al, 1998) wound and burn healing (Chithra et al, 1998a(Chithra et al, ,1998bHeggers et al, 1995), antiulcer (Koo, 1994;Saito, 1993) and antitumour (Winters et al, 1981;Saito, 1993) activities. In the past 15 years there have also been reports on the antidiabetic activity of Aloe extracts (Agarwal, 1985;Hikino et al, 1986;Ghannam et al, 1986;Ajabnoor 1990;Beppu et al, 1993Bunyapraphatsara et al, 1995Yangchaiyudha et al, 1996;Bunyapraphatsara et al, 1996). However, some negative results have also been reported (Mossa, 1985;Roman-Ramos et al, 1991;Koo, 1994).…”

Section: Introductionmentioning

confidence: 73%

“…The chronic effect of A. vera juice was investigated in combination with glibenclamide in diabetic patients and the results also supported its hypoglycaemic effect Bunyapraphatsara et al, 1996). Hikino et al (1986) isolated two hypoglycaemic glycans from A. arborescens, another Aloe species originating from Japan, as well as Beppu et al (1993), who separated two different components with hypoglycaemic activity from the leaf pulp and the leaf skin of the same plant. On the other hand, a study made with A. vera gel in STZ-induced diabetic rats confirmed its efficacy through chronic administration (Bunyapraphatsara et al, 1995) contrarily to Koo (1994) who found an elevation in plasma glucose levels of alloxan-induced diabetic rats in acute as well as chronic studies with a health product containing A. vera gel.…”

Section: Discussionmentioning

confidence: 90%

See 2 more Smart Citations

Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models

Okyar

Can

Akev

et al. 2001

Phytotherapy Research

162

View full text Add to dashboard Cite

Aloe vera (L.) Burm. fil. (= A. barbadensis Miller) (Liliaceae) is native to North Africa and also cultivated in Turkey. Aloes have long been used all over the world for their various medicinal properties. In the past 15 years, there have been controversial reports on the hypoglycaemic activity of Aloe species, probably due to differences in the parts of the plant used or to the model of diabetes chosen. In this study, separate experiments on three main groups of rats, namely, non-diabetic (ND), type I (IDDM) and type II (NIDDM) diabetic rats were carried out. A. vera leaf pulp and gel extracts were ineffective on lowering the blood sugar level of ND rats. A. vera leaf pulp extract showed hypoglycaemic activity on IDDM and NIDDM rats, the effectiveness being enhanced for type II diabetes in comparison with glibenclamide. On the contrary, A. vera leaf gel extract showed hyperglycaemic activity on NIDDM rats. It may therefore be concluded that the pulps of Aloe vera leaves devoid of the gel could be useful in the treatment of non-insulin dependent diabetes mellitus

show abstract

Section: Discussionsupporting

confidence: 77%

Section: Introductionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 90%

See 1 more Smart Citation

Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models

Okyar

Can

Akev

et al. 2001

Phytotherapy Research

162

View full text Add to dashboard Cite

show abstract

“…(Asphodelaceae) -Constituintes químicos: Látex das folhas com derivados antracênicos: aloína, barbaloína e isobarbaloína (Kuzuya et al, 2001), aloe-emodina, aloenina (Ali et al, 1999); a porção interna da folha contém mucilagem (Wozniewski et al, 1990) e glicanos (Hikino et al, 1986). Dados farmacológicos: Derivados antracênicos têm ação laxativa (Kuzuya et al, 2001;Quing et al, 1991).…”

Section: Aloe Arborescensunclassified

Dados químicos e farmacológicos sobre as plantas utilizadas como medicinais pela comunidade do bairro Ponta Grossa, Porto Alegre, Rio Grande do Sul

Vendruscolo¹,

Rates²,

Mentz³

2005

Rev. bras. farmacogn.

View full text Add to dashboard Cite

Para estas espécies foi realizada uma revisão bibliográfi ca, buscando estudos sobre sua constituição química e atividade farmacológica. Para todas as espécies foram encontrados dados químicos e para nove delas dados de atividade farmacológica. Foram encontrados estudos clínicos para quatro espécies e usos terapêuticos aprovados por organismos internacionais para três espécies. Efeitos adversos foram encontrados, na literatura, para cinco das dez espécies pesquisadas e para seis destas, o uso durante a gestação é desaconselhado.Unitermos: Etnobotânica, plantas medicinais, farmacologia.ABSTRACT: "Chemical and pharmacologic data on medicinal plants used by the community of the Ponta Grossa neighborhood, Porto Alegre, Rio Grande do Sul, Brazil". The ten most important species among all plants used as medicinal by the residents and Communitary Agents of Health from the Family Health Offi ce of Ponta Grossa neighborhood, Porto Alegre, Rio Grande do Sul, Brazil were selected. A bibliographical review for these species was accomplished, fi nding studies about the chemical constitution for all species and some pharmacologic activity for nine of them. Clinical studies for four species and therapeutic uses approved by international organisms for three species were found. It was verifi ed that according to the literature, adverse effects for fi ve of the ten researched species and for six of these the use is dissuaded during the gestation.Keywords: Ethnobotany, medicinal plants, pharmacology. INTRODUÇÃONo Brasil, a possibilidade de implementação da fi toterapia no sistema público de saúde vem sendo considerada desde 1988 (CIPLAN) e faz parte das diretrizes da I Conferência Nacional de Assistência Farmacêutica (CNMAF, 2003). A partir de então, várias inicativas pontuais para estabelecer a fi toterapia na rede pública de sáude vêm ocorrendo, com destaque para o Programa de Fitoterapia do Ceará, alicerçado no Projeto Farmácias Vivas, idealizado pelo Prof. Francisco José de Abreu Matos (Matos et al., 2001). No entanto, para a maioria das plantas nativas não existem estudos científi cos e o uso no Brasil é baseado principalmente na tradicionalidade. A OMS reconhece a importância do uso tradicional, mas para a utilização de uma planta com fi nalidade terapêutica, em nível de saúde pública, é fundamental o estabelecimento de sua segurança, efi cácia e garantia de qualidade das preparações (Lapa et al., 2003; WHO, 2002;Rates, 2001). O uso inadequado destes recursos terapêuticos pode originar efeitos adversos retardados e/ou assintomáticos, interações medicamentosas ainda não estudadas e difi cilmente reconhecidas, além de retardar o diagnóstico e tratamento apropriado (Cañigueral; Vila, 2003;Rates, 2001). Nestes termos, o emprego no atendimento primário à saúde pode gerar um impacto social (Lapa et al., 2003), com aumento de gastos nos serviços públicos de saúde, visto que as plantas com maior volume de estudos científi cos que garantam efi cácia e segurança constituem matéria-prima importada, o que torna urgente a busca de inform...

show abstract

“…Hikino et al isolated two hyperglycemic polysaccharides from Aloe arborescens at 1985. 11) Beppu et al separated two different anti-diabetic components from the leaf pulp and leaf skin of the same plant. A previous study made with Kidachi Aloe (Aloe arborescens var.…”

mentioning

confidence: 99%

Identification of Five Phytosterols from Aloe Vera Gel as Anti-diabetic Compounds

Tanaka

Misawa

Ito

et al. 2006

Biological & Pharmaceutical Bulletin

209

128

View full text Add to dashboard Cite

Of the more than 360 Aloe species known, Aloe barbadensis MILLER (Aloe vera) is the most widely used. Aloe vera contain two major parts: firstly, leaves containing a high concentration of anthraquinone compounds that have been used throughout the centuries as a cathartic and for medicinal purges; and secondly, a clear gel that has been used as a food and to treat burns and other wounds. 1,2) Several chemical components of the Aloe gel are thought to be responsible for its wound healing and immunostimulatory properties. For example, glycoprotein Aloectin A is reported to have anti-tumor and anti-ulcer effects, 3) and a 29 kDa glycoprotein has been found to increase proliferation of normal human dermal cells. 4) Most of these polysaccharides are glucomannans, mannans, or pectins with a range of molecular weights. A major focus of research has been on the carbohydrate fraction isolated from Aloe gel known as "acemannan," which comprises a polydispersed b-(1,4)-linked acetylated mannan interspersed with O-acetyl groups. 5)As a result of these studies, there have been numerous reports of Aloe having diverse biological activities, including anti-tumor activity, anti-acid activity, 6) tyrosinase inhibiting activity, 7) and antioxidant activity. 8)Two clinical trials are available from the same research group that reported hyperglycemic effects on fasting blood glucose as well as on HbA1c levels 9,10) with Aloe vera gel. Hikino et al. isolated two hyperglycemic polysaccharides from Aloe arborescens at 1985. 11) Beppu et al. separated two different anti-diabetic components from the leaf pulp and leaf skin of the same plant. A previous study made with Kidachi Aloe (Aloe arborescens var. naralensis) in streptozotocin (STZ)-induced diabetic rats confirmed its efficacy through administration, 12) contrary to Koo who reported hyperglycemic effects in diabetic rats in acute phase with a product containing Aloe vera gel. 13)In this study, we sought to determine the constituents of Aloe vera gel extract that normalize hyperglycemia in the diabetic mouse strain BKS.Cg-m ϩ/ϩ Lepr db/J (db/db), which exhibits many of the metabolic disturbances of human type 2 diabetes including hyperglycemia, obesity, and insulin resistance. Hemoglobin A1c (HbA1c), a binding product of glucose and hemoglobin, increases depending on the severity of hyperglycemia in a glucose level-dependent manner, and the level of HbA1c reflects the past blood glucose control conditions over a long period. Therefore, we tried to isolate the bioactive compounds from Aloe vera gel based on their ability to decrease the HbA1c level of db/db mice. Finally, we examined whether phytosterols and fractions isolated from Aloe vera gel play an important role in anti-hyperglycemic activity. MATERIALS AND METHODS General ProcedureMelting points were determined on a micro melting point apparatus (Yanako MP-3) without correction. NMR spectra were recorded using a Varian Unity-500 spectrometer ( C: 125 MHz). Positive APCI-MS was taken with LC-MS 2000 (Shimadzu).Preparation of Ext...

show abstract

Isolation and Hypoglycemic Activity of Arborans A and B, Glycans ofAloe arborescensvar.natalensisLeaves

Cited by 40 publications

References 2 publications

Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models

Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models

Dados químicos e farmacológicos sobre as plantas utilizadas como medicinais pela comunidade do bairro Ponta Grossa, Porto Alegre, Rio Grande do Sul

Identification of Five Phytosterols from Aloe Vera Gel as Anti-diabetic Compounds

Contact Info

Product

Resources

About