Isolation and identification of antibacterial compound from Indo–Himalayan Aconitum nagarum

Sinam, Yoirentomba Meetei; Kumar, Sanjeev; Hajare, Sachin N.; Gautam, Satyendra; Chatterjee, Suchandra; Variyar, Prasad S.; Devi, Geeta; Sharma, Arun

doi:10.1016/s2222-1808(12)60284-9

Cited by 7 publications

(1 citation statement)

References 12 publications

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“…Numerous ailments are treated by A . heterophyllum , including joint pain, rheumatic fever, bronchial asthma and endocrine disorders such as irregular menstruation. , The root of this plant shows great antimicrobial and antibiotic effects and is used in the treatment of skin, blood diseases, diarrhea and urinary tract infections. − It is also used as an expectorant and has been shown to be responsible for promoting hepatoprotective activity. ,, The phytochemical components reported in this species include aconitine, N-diethyl-N-formyllaconitine, N-succinoylanthranilate, anthorine, 12-secohetisan-2-ol and atesinol-6-benzoylheterastine. , In Ayurveda, the stem part was renowned for its better flavor and has been recommended as an alternative treatment for diabetic patients . Traditionally, the powdered forms of the stem part are mixed with honey and juice to address bronchitis and cough irritations.…”

Section: Introductionmentioning

confidence: 99%

Insights into Metabolites Profiling and Pharmacological Investigation of Aconitum heterophyllum wall ex. Royle Stem through Experimental and Bioinformatics Techniques

Ilyas,

Shad,

Bakht

et al. 2024

ACS Omega

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Section: Introductionmentioning

confidence: 99%

Insights into Metabolites Profiling and Pharmacological Investigation of Aconitum heterophyllum wall ex. Royle Stem through Experimental and Bioinformatics Techniques

Ilyas,

Shad,

Bakht

et al. 2024

ACS Omega

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Antimicrobials from medicinal plants

Pandey¹,

Agnihotri

2015

Biotechnology of Bioactive Compounds

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Identification and characterization of antibacterial compound(s) of cockroaches (Periplaneta americana)

Ali

Siddiqui

Ong

et al. 2016

Appl Microbiol Biotechnol

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Infectious diseases remain a significant threat to human health, contributing to more than 17 million deaths, annually. With the worsening trends of drug resistance, there is a need for newer and more powerful antimicrobial agents. We hypothesized that animals living in polluted environments are potential source of antimicrobials. Under polluted milieus, organisms such as cockroaches encounter different types of microbes, including superbugs. Such creatures survive the onslaught of superbugs and are able to ward off disease by producing antimicrobial substances. Here, we characterized antibacterial properties in extracts of various body organs of cockroaches (Periplaneta americana) and showed potent antibacterial activity in crude brain extract against methicillin-resistant Staphylococcus aureus and neuropathogenic E. coli K1. The size-exclusion spin columns revealed that the active compound(s) are less than 10 kDa in molecular mass. Using cytotoxicity assays, it was observed that pre-treatment of bacteria with lysates inhibited bacteria-mediated host cell cytotoxicity. Using spectra obtained with LC-MS on Agilent 1290 infinity liquid chromatograph, coupled with an Agilent 6460 triple quadruple mass spectrometer, tissues lysates were analyzed. Among hundreds of compounds, only a few homologous compounds were identified that contained isoquinoline group, chromene derivatives, thiazine groups, imidazoles, pyrrole containing analogs, sulfonamides, furanones, flavanones, and known to possess broad-spectrum antimicrobial properties, and possess antiinflammatory, anti-tumour, and analgesic properties. Further identification, characterization and functional studies using individual compounds can act as a breakthrough in developing novel therapeutics against various pathogens including superbugs.

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Isolation and identification of antibacterial compound from Indo–Himalayan Aconitum nagarum

Cited by 7 publications

References 12 publications

Insights into Metabolites Profiling and Pharmacological Investigation of Aconitum heterophyllum wall ex. Royle Stem through Experimental and Bioinformatics Techniques

Insights into Metabolites Profiling and Pharmacological Investigation of Aconitum heterophyllum wall ex. Royle Stem through Experimental and Bioinformatics Techniques

Antimicrobials from medicinal plants

Identification and characterization of antibacterial compound(s) of cockroaches (Periplaneta americana)

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