Isolation and identification of furocoumarins from the seeds of<i>Psoralea corylifolia</i>linn.

Sah, Pramilla; Agarwal, Deepshikha; Garg, S. P.

doi:10.4103/0250-474x.31012

Cited by 30 publications

(19 citation statements)

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“…This is an additional parameter with R F and UV spectrum to enhance the method specificity. Sah et al already reported that linear and angular furocoumarins appear as blue or purple spots, respectively . This observation was not confirmed in our study.…”

Section: Resultscontrasting

confidence: 99%

HPTLC methods for qualitative and quantitative analysis of selected furocoumarins in essential oils

Borgne¹,

Cicchetti²,

Bertrand³

2017

Flavour & Fragrance J

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The concentration of furocoumarins, known to induce mutagenesis, carcinogenesis and photodermatitis under UV radiation, is limited by the EU cosmetic regulation in consumer products such as cosmetics, sun protection and bronzing formulations. The bergapten concentration is also limited by the International Fragrance Association. Analytical methods have been proposed for their quantification using high‐performance liquid chromatography (HPLC) coupled with UV detection or mass spectrometry with limits of detection (LOD) and quantification (LOQ) in accordance with the regulation. These methods are time and solvent consuming for routine quality control analyses. In this context, simple and fast HPLC methods in one‐ (1‐D) and two‐ (2‐D) dimensions were developed for the simultaneous analysis of the 15 most common furocoumarins reported in Citrus essential oils: psoralen, bergapten, xanthotoxin, isopimpinellin, oxypeucedanin, oxypeucedanin hydrate, byakangelicol, byakangelicin, heraclenin, 8‐geranyloxypsoralen, bergamottin, imperatorin, isoimperatorin, phellopterin, epoxybergamottin along with five other furocoumarins known to be present in Angelica, bergamot or Heracleum species: angelicin, bergaptol, isobergapten, psora‐4 and 5‐(4‐phenoxybutoxy)psoralen. The 1‐D method was validated for the quantification of bergapten using a Camag TLC Scanner as a detector. The LOD was determined at 2 mg/kg. The method was linear from 2 to 100 mg/kg and the method range was defined using accuracy profiles at with an 80% tolerance interval, with a 30% error, to be 5–100 mg/kg in acetonitrile and 13–100 mg/kg in matrix.

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Section: Resultscontrasting

confidence: 99%

HPTLC methods for qualitative and quantitative analysis of selected furocoumarins in essential oils

Borgne¹,

Cicchetti²,

Bertrand³

2017

Flavour & Fragrance J

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“…Seeds are usually brownish-black in color, smooth, and adhere to the pericarp [28,29]. The plant is widely used in several skin diseases such as psoriasis [30], leucoderma and leprosy [31]. The therapeutic action of P. corylifolia against various diseases such as asthama, diarrhoea, alopecia areata [32], impotency, menstruation disorder and uterine hemorrhage [33].…”

Section: Introductionmentioning

confidence: 99%

Insecticidal and genotoxic activity of Psoralea corylifolia Linn. (Fabaceae) against Culex quinquefasciatus Say, 1823

Dua

Kumar²,

Pandey

et al. 2013

Parasites Vectors

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BackgroundIndiscriminate use of synthetic insecticides to eradicate mosquitoes has caused physiological resistance. Plants provide a reservoir of biochemical compounds; among these compounds some have inhibitory effect on mosquitoes. In the present study the larvicidal, adulticidal and genotoxic activity of essential oil of Psoralea corylifolia Linn. against Culex quinquefasciatus Say was explored.MethodsEssential oil was isolated from the seeds of P. corylifolia Linn. Larvicidal and adulticidal bioassay of Cx. quinquefasciatus was carried out by WHO method. Genotoxic activity of samples was determined by comet assay. Identification of different compounds was carried out by gas chromatography- mass spectrometry analysis.ResultsLC50 and LC90 values of essential oil were 63.38±6.30 and 99.02±16.63 ppm, respectively against Cx. quinquefasciatus larvae. The LD50 and LD90 values were 0.057±0.007 and 0.109±0.014 mg/cm2 respectively against adult Cx. quinquefasciatus,. Genotoxicity of adults was determined at 0.034 and 0.069 mg/cm2. The mean comet tail length was 6.2548±0.754 μm and 8.47±0.931 μm and the respective DNA damage was significant i.e. 6.713% and 8.864% in comparison to controls. GCMS analysis of essential oil revealed 20 compounds. The major eight compounds were caryophyllene oxide (40.79%), phenol,4-(3,7-dimethyl-3-ethenylocta-1,6-dienyl) (20.78%), caryophyllene (17.84%), α-humulene (2.15%), (+)- aromadendrene (1.57%), naphthalene, 1,2,3,4-tetra hydro-1,6-dimethyle-4-(1-methyl)-, (1S-cis) (1.53%), trans- caryophyllene (0.75%), and methyl hexadecanoate (0.67%).ConclusionEssential oil obtained from the seeds of P. corylifolia showed potent toxicity against larvae and adult Cx. quinquefasciatus. The present work revealed that the essential oil of P. corylifolia could be used as environmentally sound larvicidal and adulticidal agent for mosquito control.

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“…The roots of P. corylifolia has been investigated for bioactive compounds. It was found that furanocoumarins psoralen and isopsoralen isolated from a petroleum ether extract were responsible for the anti‐feedant activity against instar Spodoptera litura larvae (Sah et al, ; Figure ).…”

Section: Phytochemical Constituentsmentioning

confidence: 99%

“…In India, it is found as a wild weed in cold weather of the Himalayas. It is found in Bombay, Bengal, Utter Pradesh, Rajasthan, in valley of Karnataka, Bihar, and Deccan (Sah, Agarwal, & Garg, ; Sharma, Yelne, Dennis, Joshi, & Billore, ). The plants are widely distributed in the Himalayan regions of China and Pakistan and there are reports that they have been seen in Southern Africa (Deshaprabhu, ; Srivastava, Singh Rawat, & Mehrotra, ; Xiong et al, ).…”

Section: Introductionmentioning

confidence: 99%

Psoralea corylifolia L: Ethnobotanical, biological, and chemical aspects: A review

Alam

Khan

Asad

2017

Phytotherapy Research

139

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Psoralea corylifolia L. (Leguminosae) is a well-known traditional medicinal plant used from ancient times for treatment of various ailments. It is widely distributed and an important part of therapeutics in Ayurveda and in Chinese medicines. The aim of this review is to present comprehensive and most up to date report on its ethnobotanical, ethnopharmacological, clinical, phytochemical, and side effects. Studies on the ethnobotanical, ethnopharmacological, clinical, phytochemical, and side effects of P. corylifolia were published until year 2017 and were searched using various scientific databases. The scientific literature searched revealed that these plant species has been extensively investigated in vivo and in vitro for various biological and phytochemical studies. It has cardiotonic, vasodilator, pigmentor, antitumor, antibacterial, cytotoxic, and anti-helminthic properties and locally used for alopecia, inflammation, leukoderma, leprosy, psoriasis, and eczema. So far, about a hundred bioactive compounds have been isolated from seeds and fruits, and most important compounds identified belongs to coumarins, flavonoids, and meroterpenes groups. This review article summarized the most updated scientific literature on bioactive phytochemical and biological activities of P. corylifolia. This article will be a useful addition to providing information for future research, and more standard clinical trials are needed for the plant to be used as therapeutic agent.

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Isolation and identification of furocoumarins from the seeds ofPsoralea corylifolialinn.

Cited by 30 publications

References 1 publication

HPTLC methods for qualitative and quantitative analysis of selected furocoumarins in essential oils

HPTLC methods for qualitative and quantitative analysis of selected furocoumarins in essential oils

Insecticidal and genotoxic activity of Psoralea corylifolia Linn. (Fabaceae) against Culex quinquefasciatus Say, 1823

Psoralea corylifolia L: Ethnobotanical, biological, and chemical aspects: A review

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