Starting from 3,6‐dichloropyridazine, a new route is described to antihypertensive 5,6‐diarylpyridazin‐3‐ones. This pathway comprises the regioselective metalation followed by a substitution of the trimethylsilyl moeity. The introduction of iodine by another metalation allowed the cross coupling of arylboronic acids. The 6‐methoxy group was then cleaved to afford the pyridazinones.