Isolation and identification of metabolites of bakuchiol in rats

2020

A new aurone, (2 Z)-2-[(4′-hydroxyphenyl) methylene]-6-methoxy-7-prenyl-3(2 H)-benzofurane (1), together with 6 known compounds (2-7), was isolated from the EtOAc-soluble extract of the seeds of Psoralea corylifolia. Their structures were elucidated on the basis of spectroscopic methods. All compounds were evaluated for in vitro inhibitory activity against a human colon cancer cell line (SW620). Compounds 1 to 3 showed moderate cytotoxicity against the SW620 cells with IC50 values ranging from 24.31 to 28.72 μM. Among these compounds, 1 showed higher cytotoxicity against SW620 cells with an IC50 value of 24.31 μM.

mentioning

confidence: 99%

“…1 H and13 C Nuclear Magnetic Resonance Spectral Data of Compound 1 in Acetone-d 6 ( 1 H: 500 MHz and 13 C: 125 MHz).…”

mentioning

confidence: 99%

Anticolon Cancer Potential of (2Z)-2-[(4′-Hydroxyphenyl) Methylene]-6-Methoxy-7-Prenyl-3(2H)-Benzofurane, a New Aurone From Psoralea corylifolia

2020

“…Psoralea corylifolia L. (Leguminosae), an important Chinese folk medicine, is distributed widely in Southeast Asia. The seeds of P. corylifolia are traditionally used to treat bacterial infections, 3 osteoporosis, 3 asthma, 4 spermatorrhea, 3 and gynecological bleeding. 5 Published studies have shown that P. corylifolia has a large number of biological constituents including flavonoids, 6 meroterpenes, 7 and coumarins 8 with reported biological activities such as antioxidant, 9 anti-inflammatory, 10 and antibacterial 11 properties.…”

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confidence: 99%

“…During the course of our search for DGAT inhibitors from P. corylifolia, a new aurone was isolated from the EtOAc extract of the seeds of P. corylifolia, together with 5 known compounds (2)(3)(4)(5)(6). Herein, we report the isolation and structural elucidation of the new aurone and the evaluation of DGAT inhibitory activity.…”

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confidence: 99%

A New Aurone and Other Constituents From the Seeds of Psoralea corylifolia With Their Diacylglycerol Acyltransferase Inhibitory Activity

Ren

Dong

2019

A new aurone (1), together with 5 known compounds (2-6), were isolated from EtOAc-soluble extract of the seeds of Psoralea corylifolia. Their structures were elucidated on the basis of spectroscopic methods. All compounds were evaluated for in vitro inhibitory activity against diacylglycerol acyltransferase (DGAT). Among them, compound 1 showed selective inhibitory activity on DGAT1 with IC50 value of 54.9 ± 1.4 µM.

“…Psoralea corylifolia L. (Leguminosae), belonging to the family of legumes, is an annual herbaceous plant distributed widely in Southeast Asia [5]. It is renowned as a polyphenol-rich plant and the dried seeds of P. corylifolia have been used as a Chinese traditional medicine for treating a large range of diseases such as asthma [6], spermatorrhea [7], bacterial infections [7], gynecological bleeding [7] and osteoporosis [7]. Previous studies on P. corylifolia led to the isolation of bioactive constituents including coumarins [4], flavonoids [8] and meroterpenoids [9].…”

mentioning

confidence: 99%

A New Flavanone from Seeds of Psoralea corylifolia with α-Glucosidase Inhibitory Activity

Dong

Ren

2018

A new flavanone (2S)-7,4'-hydroxyl-6-(2'',3''-epoxy-3''-methylbutyl)flavanone (1), together with five known compounds (2-6) were isolated from EtOAcsoluble extract of seeds of Psoralea corylifolia. Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. All compounds were evaluated for in vitro inhibitory activity against α-glucosidase. Among them, new compound 1 was found to exhibit inhibitory activity on α-glucosidase with IC 50 value of 29.2 µM.