2009
DOI: 10.1021/jf902496d
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Isolation and Identification of Novel Macrocyclic Lactones from Streptomyces avermitilis NEAU1069 with Acaricidal and Nematocidal Activity

Abstract: Bioactivity-guided fractionation of Streptomyces avermitilis NEAU1069 fermentation broth was used to isolate and determine the chemical identity of bioactive constituents with acaricidal and nemotocidal activity. The structures of novel compounds 1 and 2 were determined on the basis of spectroscopic analysis, including 1D and 2D NMR as well as HRESI-MS, ESI-MS of spectrometry analysis, UV and IR spectroscopic analyses, and comparison with data from the literature. The acaricidal activities of the isolated comp… Show more

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Cited by 30 publications
(21 citation statements)
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“…Along with previously obtained analogs of doramectin, avermectin and milbemycin from S. avermitilis NEAU1069, 3,4 we believe that these two new compounds possibly have important roles in understanding and perfecting the proposed biosynthetic pathways of avermectins and milbemycins.…”
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confidence: 59%
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“…Along with previously obtained analogs of doramectin, avermectin and milbemycin from S. avermitilis NEAU1069, 3,4 we believe that these two new compounds possibly have important roles in understanding and perfecting the proposed biosynthetic pathways of avermectins and milbemycins.…”
mentioning
confidence: 59%
“…3,4 The strain was maintained on a YMS medium containing soluble starch (Bei Jing Ao Bo Xing, Beijing, China) 10 g, yeast extract (Bei Jing Ao Bo Xing) 2 g, KNO 3 Two new doramectin analogs from Streptomyces avermitilis X-J Wang et al of sterile water was added to the slant of the YMS medium. The spores were scraped and transferred onto a sterile tube containing glass beads; the spore suspension was then filtered through six layers of a sterile filter cheesecloth and adjusted to 10 7 -10 8 c.f.u.…”
Section: Strain Fermentation Isolation and Purification Of Compoundsmentioning
confidence: 99%
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“…In our previous study, two novel macrocyclic lactones and three milbemycins, including one new compound, with acaricidal and insecticidal activities were isolated from Streptomyces avermitilis NEAU1069 [10] [11]. In further studies concerning the chemical diversity of the constituents of S. avermitilis NEAU1069, the bioassay-guided fractionation was employed to investigate the active metabolites with acaricidal activity.…”
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confidence: 99%
“…1 are the presence of a,b-conjugated ketone (d(C) 199.5) in 4, and that the C(2) -C(7) aromatic moiety in 3 was replaced by a cyclohexene ring as in doramectin [11]. This was further supported by HMBC correlations of Me(32), with C(3), C(4), and C(5), of Me(33) with C(7), and of HÀC(2) with C(1) (Fig.…”
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confidence: 99%