Isolation and identification of phenolic compounds from the seeds of Perilla frutescens (L.) and their inhibitory activities against α-glucosidase and aldose reductase

Ha, Tae Joung; Lee, Jin Hwan; Lee, Myoung-Hee; Lee, Byeong Won; Kwon, Hyun Sook; Park, Chang-Hwan; Shim, Kang-Bo; Kim, Hyun-Tae; Baek, In-Youl; Jang, Dae Sik

doi:10.1016/j.foodchem.2012.05.104

Cited by 152 publications

(103 citation statements)

References 26 publications

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“…Luteolin has been previously reported as an un-competitive a-glucosidase inhibitor (Ha et al, 2012), in fact when the enzyme is treated with this compound, v max is altered while no change in the K m value is recorded. This suggests that compounds, other than luteolin, present in the extract, may contribute to the total inhibitory activity of A. tenorii conferring the un-competitive mechanism of inhibition.…”

Section: Resultsmentioning

confidence: 85%

“…Moreover, according to our results ( Figure 2) extracts of A. tenorii are endowed with an interesting a-glucosidase inhibitory activity (the IC 50 value is 32.07 ± 2.2 mg/mL). Hypothesizing that the activity exhibited by the extract was probably due to flavonoids, in particular luteolin, which is a well-known a-glucosidase inhibitor (Ha et al, 2012) the purified compound was tested, giving an IC 50 value of 47 ± 1.5 mM (13.23 mg/mL) (Figure 3). Moreover, considering the high content of chlorogenic acid recognized in the extract, pure standard of this compound was also tested and an activity considerably lower than luteolin was found (IC 50 1.3 ± 0.2 mM; 461 mg/ml).…”

Section: Resultsmentioning

confidence: 99%

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Antioxidant andα-glucosidase inhibitory activities ofAchillea tenorii

Venditti¹,

Maggi

Vittori

et al. 2015

Pharmaceutical Biology

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Context: There is a need for the discovery of novel natural remedies to prevent and treat metabolic disorders such as hyperglycemia, type II non-insulin-dependent diabetes mellitus, and obesity. Several Achillea species have been utilized for centuries all around the world and are generally considered effective as hypoglycemic. Objective: Considering the ethnobotanical uses of Achillea genus, we evaluated the in vitro inhibitory activity of Achillea tenorii Grande (Asteraceae) extract on a-glucosidase, which is a valuable target to prevent and treat metabolic disorders. We also tested its antioxidant activity. Moreover, the phytochemical profile was discussed from a chemotaxonomic point of view. Materials and methods: In vitro a-glucosidase inhibition of crude ethanolic extract obtained from the aerial parts was assayed as well as the in vitro antioxidant activity (ABTS, DPPH, and FRAP-FZ tests) was measured. The extract was characterized from a phytochemical point of view by means of spectroscopic analysis. Results: The extract results endowed with a-glucosidase inhibitory activity (IC 50 32 mg/mL) with a particular mechanism of action definable as un-competitive, which differed from the mechanism observed for the best-known a-glucosidase inhibitor (acarbose and miglitol). In addition, a considerable antioxidant potential has been found for A. tenorii extract, which resulted mainly constituted by phenolic compounds such as caffeoylquinic acids and flavonoids. Discussion and conclusions: These results suggest the potential of A. tenorii as a possible natural remedy to prevent and treat metabolic disorders of carbohydrates.

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Section: Resultsmentioning

confidence: 85%

Section: Resultsmentioning

confidence: 99%

Antioxidant andα-glucosidase inhibitory activities ofAchillea tenorii

Venditti¹,

Maggi

Vittori

et al. 2015

Pharmaceutical Biology

View full text Add to dashboard Cite

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“…Acetone extract of the leaves of Picralima nitida was also reported to be a competitive inhibitor of α-glucosidase [18], although there are more reports of plant extracts and natural products as non-competitive [19,20] and mixed-type [21] α-glucosidase inhibitors. Our study revealed that BF differs in its mode of inhibition from quercetin, which exerts either noncompetitive [22] or mixed-type [23,24] inhibition on α-glucosidase.…”

Section: Discussionmentioning

confidence: 99%

Alpha-Glucosidase Inhibitory and Antioxidant Activity of Solvent Extracts and Fractions of <i>Typha domingensis</i> (Typhaceae) Fruit

et al. 2015

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“…[3,4] Perilla frutescens (L.) Britt (PF), commonly referred to as perilla, is an annual short-day plant belonging to the mint family Lamiaceae, which is primarily cultivated and consumed in Asian countries such as Korea, China, and Japan. [5][6][7] Perilla is an important crop source of oil and edible vegetable with many beneficial properties including anti-inflammatory, anti-allergic, anti-carcinogenic effects, and antioxidant. [8][9][10] The seeds of perilla are commonly used for oil extraction.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive evaluation of the antioxidant capacity of Perilla frutescens leaves extract and isolation of free radical scavengers using step-wise HSCCC guided by DPPH-HPLC

Kwon

Wang

Hwang

et al. 2017

International Journal of Food Properties

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To comprehensively examine the antioxidant capacity of Perilla frutescens leaves extract, eight assays including hydroxyl radical, hydrogen peroxide, ferrous ionchelating, total antioxidant capacity, nitric oxide, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), 2,2′-diphenyl-1-picrylhydrazyl, and ferrous reducing antioxidant assays were employed. The results indicated that the ethyl acetatesoluble fraction of P. frutescens leaves extract displayed the highest antioxidant activities. The antioxidant constituents from ethyl acetate-soluble fraction of P. frutescens leaves extract were screened by 2,2′-diphenyl-1-picrylhydrazyl highperformance liquid chromatography, and 11 compounds were identified after isolation using step-wise high-speed countercurrent chromatography. Protocatechuic acid, chlorogenic acid, caffeic acid, rosmarinic acid, luteolin, methyl-rosmarinic acid, apigenin, and 4′,5,7-trimethoxyflavone are the major antioxidant constituents in ethyl acetate-soluble fraction of P. frutescens leaves extract. ARTICLE HISTORY

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Isolation and identification of phenolic compounds from the seeds of Perilla frutescens (L.) and their inhibitory activities against α-glucosidase and aldose reductase

Cited by 152 publications

References 26 publications

Antioxidant andα-glucosidase inhibitory activities ofAchillea tenorii

Antioxidant andα-glucosidase inhibitory activities ofAchillea tenorii

Alpha-Glucosidase Inhibitory and Antioxidant Activity of Solvent Extracts and Fractions of <i>Typha domingensis</i> (Typhaceae) Fruit

Comprehensive evaluation of the antioxidant capacity of Perilla frutescens leaves extract and isolation of free radical scavengers using step-wise HSCCC guided by DPPH-HPLC

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