Isolation and Identification of the Icosalides — Cyclic Peptolides with Selective Antibiotic and Cytotoxic Activities.

Abstract

Peptides U 0400Isolation and Identification of the Icosalides -Cyclic Peptolides with Selective Antibiotic and Cytotoxic Activities. -The new cyclic depsipeptides (I) and (II) are extracted from two different fungal species found on dead ground wood in a tropical rain forest. Icosalide A1 (I) displays antimicrobial activity and icosalides A2 (IIa) and B (IIb) are cytotoxic to replicating MDCK cells. The unusual D-leucine moiety in (I) is an interesting deviation from the predomination of L-amino acids. -(BOROS*, C.; SMITH, C. J.; VASINA, Y.; CHE, Y.; DIX, A. B.; DARVEAUX, B.; PEARCE, C.; J. Antibiot. 59 (2006) 8, 486-494; MYCOsearch, OSI Pharm., Durham, NC 27707, USA; Eng.) -H. Haber 08-182

NW-G03, a related cyclic hexapeptide compound of NW-G01, produced by Streptomyces alboflavus 313

“…[11][12][13][14][15] As summarized in Table 4, the in vitro compound inhibited the growth of cell lines BEL-7402, HCT-116 and H460 in the concentration of 30 mg ml À1 .…”

Discovery and biosynthesis of gladiochelins: unusual lipodepsipeptide siderophores fromBurkholderia gladioli

“…33 We have recently discovered that B. gladioli BCC0238, isolated from the sputum of a child with cystic fibrosis (CF), produces several specialised metabolites. These include gladiolin, a novel macrolide with potent activity against drug resistant Mycobacterium tuberculosis clinical isolates, 23 and icosalide A1, 34 an asymmetric lipopeptodiolide antibiotic originally isolated from an Aureobasidium species fungus, 35 but subsequently shown to be produced by various strains of B. gladioli including one associated with the fungus. 34,36 Analysis of the B. gladioli BCC0238 complete genome sequence identified several gene clusters encoding cryptic nonribosomal peptide synthetase (NRPS), polyketide synthase (PKS) and hybrid NRPS-PKS assembly lines.…”