Isolation and identification of three new chromones from the leaves of Pimenta dioica with cytotoxic, oestrogenic and anti-oestrogenic effects

Doyle, Brian J.; Lawal, Temitope O.; Locklear, Tracie; Hernandez, Lorraina; Pérez, Alice L.; Patel, Udeshi; Patel, Shitalben; Mahady, Gail B.

doi:10.1080/13880209.2018.1448873

Cited by 12 publications

(2 citation statements)

References 44 publications

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“…Anti-oxidant [87], anti-diabetic effects [89] and metabolic disorders via upregulation of TGR 5 [90]; oestrogenic effects, inhibitory effect on breast and gastric cancer cells [88].…”

Section: Female Inflorescences Of Humulus Lupulus (Hops)mentioning

confidence: 99%

Peucedanum ostruthium Inhibits E-Selectin and VCAM-1 Expression in Endothelial Cells through Interference with NF-κB Signaling

et al. 2020

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Twenty natural remedies traditionally used against different inflammatory diseases were probed for their potential to suppress the expression of the inflammatory markers E-selectin and VCAM-1 in a model system of IL-1 stimulated human umbilical vein endothelial cells (HUVEC). One third of the tested extracts showed in vitro inhibitory effects comparable to the positive control oxozeaenol, an inhibitor of TAK1. Among them, the extract derived from the roots and rhizomes of Peucedanum ostruthium (i.e., Radix Imperatoriae), also known as masterwort, showed a pronounced and dose-dependent inhibitory effect. Reporter gene analysis demonstrated that inhibition takes place on the transcriptional level and involves the transcription factor NF-κB. A more detailed analysis revealed that the P. ostruthium extract (PO) affected the phosphorylation, degradation, and resynthesis of IκBα, the activation of IKKs, and the nuclear translocation of the NF-κB subunit RelA. Strikingly, early effects on this pathway were less affected as compared to later ones, suggesting that PO may act on mechanism(s) that are downstream of nuclear translocation. As the majority of cognate NF-κB inhibitors affect upstream events such as IKK2, these findings could indicate the existence of targetable signaling events at later stages of NF-κB activation.

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“…Anti-oxidant [87], anti-diabetic effects [89] and metabolic disorders via upregulation of TGR 5 [90]; oestrogenic effects, inhibitory effect on breast and gastric cancer cells [88].…”

Section: Female Inflorescences Of Humulus Lupulus (Hops)mentioning

confidence: 99%

Peucedanum ostruthium Inhibits E-Selectin and VCAM-1 Expression in Endothelial Cells through Interference with NF-κB Signaling

et al. 2020

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“…These biological properties of medicinal plants are exploited in the treatment of some estrogen-dependent ailments. Thus, Doyle et al [5] and Watcho et al [6] have respectively reported that Pimenta dioica and Bambusa vulgaris alleviate menopause-induced bone and metabolic damages. Erigeron floribundus (Asteraceae) is an herbaceous plant commonly found in Cameroon as a weed along roadsides.…”

Section: Introductionmentioning

confidence: 99%

Effects of the Mixture of Erigeron floribundus (Asteraceae) and Tragia benthamii (Euphorbiaceae) on the Growth and Architecture of Estrogen-Sensitive Sexual Organs

Djuidje¹,

Ngadjui²,

Tetsatsi³

et al. 2021

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The mixture of Erigeron floribundus and Tragia benthamii (AEMEFTB) is traditionally used against pelvic pain, dysmenorrhea and female sexual dysfunctions. In a recent study, we showed that the aqueous extract of the mixture of AEMEFTB suppresses the endometrium growth in rats with experimental endometriosis. The present study was aimed at investigating the effects of AEM-EFTB on estrogen's sensitive sexual organs growth and architecture. Immature gonado-intact female rats were randomly distributed into 7 groups of 5 animals each and daily treated during one week with either distilled water (10 ml/kg), refined palm oil (1 ml/kg) or 17β-estradiol (1 μg/day). Plant extract groups received aqueous extract of AEMEFTB at 130 or 260 mg/kg. The remaining groups were co-administered with 17β-estradiol (1 μg) plus 130 or 260 mg/kg of the plant mixture. Moreover, thirty-five immature female rats were bilaterally ovariectomized, then left and treated as before. Five other females, considered as sham animals, orally received distilled water (10 ml/kg). The body weight of each animal was recorded daily and at the end of the treatment (day 8), animals were sacrificed under anesthesia, and the vaginas, uteruses and ovaries (if any) were collected for analysis. Treatment with AEMEFTB did not affect the ovarian weight and architecture in gonado-intact immature female rats. However, a moderate increase of the uterine weight was recorded in animals treated with plant mixture at the high dose (260 mg/kg). On the contrary, a drop in the uterine growth index and total plasmatic proteins was observed in immature females coadministered with the extract and estradiol. Results from this work showed that the mixture of Erigeron floribundus and Tragia benthamii possesses a weak but observable estrogen-mimetic potential.

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Estrogenic flavonoids and their molecular mechanisms of action

Kiyama

2023

The Journal of Nutritional Biochemistry

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Isolation and identification of three new chromones from the leaves of Pimenta dioica with cytotoxic, oestrogenic and anti-oestrogenic effects

Cited by 12 publications

References 44 publications

Peucedanum ostruthium Inhibits E-Selectin and VCAM-1 Expression in Endothelial Cells through Interference with NF-κB Signaling

Peucedanum ostruthium Inhibits E-Selectin and VCAM-1 Expression in Endothelial Cells through Interference with NF-κB Signaling

Effects of the Mixture of <i>Erigeron floribundus</i> (<i>Asteraceae</i>) and <i>Tragia benthamii</i> (<i>Euphorbiaceae</i>) on the Growth and Architecture of Estrogen-Sensitive Sexual Organs

Estrogenic flavonoids and their molecular mechanisms of action

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Isolation and identification of three new chromones from the leaves of Pimenta dioica with cytotoxic, oestrogenic and anti-oestrogenic effects

Cited by 12 publications

References 44 publications

Peucedanum ostruthium Inhibits E-Selectin and VCAM-1 Expression in Endothelial Cells through Interference with NF-κB Signaling

Peucedanum ostruthium Inhibits E-Selectin and VCAM-1 Expression in Endothelial Cells through Interference with NF-κB Signaling

Effects of the Mixture of &lt;i&gt;Erigeron floribundus&lt;/i&gt; (&lt;i&gt;Asteraceae&lt;/i&gt;) and &lt;i&gt;Tragia benthamii&lt;/i&gt; (&lt;i&gt;Euphorbiaceae&lt;/i&gt;) on the Growth and Architecture of Estrogen-Sensitive Sexual Organs

Estrogenic flavonoids and their molecular mechanisms of action

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Effects of the Mixture of <i>Erigeron floribundus</i> (<i>Asteraceae</i>) and <i>Tragia benthamii</i> (<i>Euphorbiaceae</i>) on the Growth and Architecture of Estrogen-Sensitive Sexual Organs