Isolation and Properties of Sialodacryoadenitis Virus of Rats

Replication of sialodacryoadenitis virus of rat in LBC cell culture

“…High incidences of antibody to MTIV in rat. colonies (2,5) suggest that RCV and SDAV might be perpetuating in rat colonies without any apparent illness, while outbreaks of sialodacryoadenitis are common in laboratory rat colonies (4,6,9), causing serious problems in breeding and experimentation.…”

“…4 illustrates representative virM growth curves which were obtMned in LBC cell cultures infected with the virus at an input multiplicity of Fig. 4. Growth curves of SDAV strain 681 in the LBC cell culture.…”

Rat Coronavirus

“…Although RCV, SDAV and CARS can be separated by some criteria, the similarities among them strongly outweigh the differences (TABLE I) and suggest they may merely be strains of a prototype virus. This possibility is strengthened by reports that show the physicochemical and antigenic properties of several coronaviruses isolated from naturally affected rats closely resemble those of SDAV (6,7). Rat coronaviruses are all moderate-sized, enveloped viruses with coronavirus morphology.…”

Viral Disease

“…Additional RCV strains have been reported since the initial isolations by Parker and Bhatt. These include Japanese isolatesdCARS (Kojima et al, 1980;Maru and Sato, 1982)dand US isolates RCV-BCMM, RCV-W, and RCV-NJ (Compton et al, 1999a;1999b).…”