Isolation and purification of coumarin compounds from Cortex fraxinus by high-speed counter-current chromatography

Liu, Renmin; Sun, Qinghua; Sun, Ailing; Cui, Jichun

doi:10.1016/j.chroma.2005.03.023

Cited by 82 publications

(31 citation statements)

References 8 publications

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“…The physical and spectral data were in accordance with those reported in the literature (Liu et al, 2005). This is the first report for its isolation from the genus Chorisia.…”

Section: -Hydroxymethyl Furfural [5-(hydroxymethyl) Furan-2-carsupporting

confidence: 78%

Chemical constituents from Chorisia chodatii flowers and their biological activities

et al. 2015

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From the flowers of Chorisia chodatii Hassl.(family: Bombacaceae), seventeen compounds were isolated and identified, including: two sterols, b-sitosterol (1) and bsitosterol 3-O-b-D-glucopyranoside (10); two furanoids, 5-hydroxymethyl furfural (3) and (3R,4R,5S)-3,4-dihydroxy-5-methyl-dihydrofuran-2-one (12); two coumarins, scopoletin (8) and aesculetin (9); four phenolic acids and esters, ethyl vanillate (4), vanillic acid (5), protocatechuic acid ethyl ester (6) and p-hydroxy benzoic acid (7); five flavonoids, kaempferol 3-O-b-D-(6 00 -acetyl)-glucopyranoside (13), kaempferol 3-O-b-D-(6 00 -E-p-coumaroyl)-glucopyranoside (14), kaempferol 3-O-b-D-glucopyranoside (15), luteolin 7-O-b-D-glucopyranoside (16) and apigenin 7-Oneohesperidoside (17), in addition to mono-octyl phthalate (2) and succinic acid (11). All the isolated metabolites were reported for the first time from this plant, and among them, compounds (3), (4), (6), (7), (12) and (13) were isolated for the first time from family Bombacaceae. Besides, this is the first report for isolation of (2) in a pure form from a natural source. These phytochemical data revealed important chemotaxonomic value and may broaden the use of this plant in future phytotherapy. Moreover, all of the obtained phytocompounds were evaluated for their DPPH free radical scavenging properties and cytotoxic activities against the human lung cancer cell line A549.

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“…The physical and spectral data were in accordance with those reported in the literature (Liu et al, 2005). This is the first report for its isolation from the genus Chorisia.…”

Section: -Hydroxymethyl Furfural [5-(hydroxymethyl) Furan-2-carsupporting

confidence: 78%

Chemical constituents from Chorisia chodatii flowers and their biological activities

et al. 2015

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“…Compounds 1-5 were identifi ed as scopoletin (Carpinella et al, 2005), aesculetin, fraxetin, fraxin and aesculin (Liu et al, 2005), respectively, by comparing their physicochemical and spectroscopic data with those published in the literature. Previously, the isolation and structural elucidation of 12 coumarins, 6-15 from A. dahurica (Thanh et al, 2004), 16 from E. daniellii (Yoo et al, 2002) and 17 from P. japonicum (Zheng et al, 2005) were reported.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant activities of coumarins from Korean medicinal plants and their structure–activity relationships

Thương

Hung

Ngoc

et al. 2009

Phytotherapy Research

122

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The aim of this work was to study the structure-activity relationships of the antioxidant activity of natural coumarins isolated from four Korean medicinal plants (1-17) and four purchased coumarins (18-21). The free radical scavenging and lipid peroxidation assays revealed that five phenolic coumarins, scopoletin (1), aesculetin (2), fraxetin (3), umbelliferone (18) and daphnetin (19), possessed considerable antioxidant activities. The coumarins having a catechol group, 2, 3 and 19, showed significant free radical scavenging activity and inhibitory effects on lipid peroxidation, indicating that the catechol group significantly contributed to the antioxidant activities of coumarins. In contrast, the sugar moiety markedly reduced the activities of coumarin glycosides. The results also demonstrate that the alpha-pyrone ring of coumarins significantly enhanced the capacity of inhibiting oxidative reactions of coumarins.

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“…Other three compounds were identified as gallic acid (1) [6], brevifolin carboxylic acid (3) [7] and fraxin (4) [8] by comparing physical and spectral data with the literature (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

“…Recently, we have reported two new phorbol derivatives and twelve known phenolic compounds from this plant [5]. On continuing further chemical analysis, we isolated and identified a new phenolic compound, 4-dehydrochebulic acid-1,6-dimethyl ester (2) and three known compounds such as gallic acid (1) [6], brevifolin carboxylic acid (3) [7] and fraxin (4) [8] from the leaves of Sapium insigne, which are reported in this paper. All these compounds are reported for the first time in this plant.…”

Section: Introductionmentioning

confidence: 91%

A new phenolic compound, 4-dehydrochebulic acid-1,6-dimethyl ester from Sapium insigne leaves

2009

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Isolation and purification of coumarin compounds from Cortex fraxinus by high-speed counter-current chromatography

Cited by 82 publications

References 8 publications

Chemical constituents from Chorisia chodatii flowers and their biological activities

Chemical constituents from Chorisia chodatii flowers and their biological activities

Antioxidant activities of coumarins from Korean medicinal plants and their structure–activity relationships

A new phenolic compound, 4-dehydrochebulic acid-1,6-dimethyl ester from Sapium insigne leaves

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