Isolation and quantification of flavonoids from ethanol extract of Costus igneus rhizome (CiREE) and impact of CiREE on hypoglycaemic, electron microscopic studies of pancreas in streptozotocin (STZ)-induced diabetic rats

Kalailingam, Pazhanichamy; Balasubramanian, K.; Kannaian, Bhuvaneswari; Mohammed, Aashefa Kalandar Naina; Meenakshisundram, Kavitha; Eevera, T.; Kaliaperumal, Rajendran

doi:10.1016/j.bionut.2013.01.001

Cited by 11 publications

(9 citation statements)

References 27 publications

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“…The hexane extract of costus sp. induces a significant fall in blood HDL levels when compared to the control level, supporting the extract's hypolipidemic effect [54].…”

Section: Discussionmentioning

confidence: 74%

Antidiabetic Effect of Hexane Extract of Costus Speciosus and Metformin in Rats

Kilany

Soliman

Marie

et al. 2022

Advances in Environmental and Life Sciences

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The aim of the research was to examine the effects of various antidiabetic agents in albino rats by the selection of two antidiabetic agents, one of which is chemical (metformin) and the other is a natural plant (Costus), and to investigate their possible beneficial effects on diabetes. A total of 36 normal male adults albino rats ( Sprague strain) were randomly assigned into six equal groups. Three of them were normal rats. The first normal group served as the control group. The second normal group received costus rhizome extract at a dose of 250 mg/ kg B. W. once a day for 30 days. The third normal group received metformin cure at a dose of 500 mg/ kg B. W. once a day for 30 days. The other three groups were diabetic rats that injected STZ (45 mg/ kg B.W. /i.p.). The first diabetic group served as control group. The second diabetic group received costus rhizome extract at a dose of 250 mg/ kg B. W. by oral gavage once a day for 30 days, the third diabetic group received metformin cure at a dose of 500 mg/ kg B. W. by oral gavage once a day for 30 days. Our results showed that metformin and hexane extract of costus sp. treated groups revealed enhancement and improvement of disturbance of liver functions, kidney functions, immunological parameters, antioxidant parameters and histopathology of the pancreas.

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“…The hexane extract of costus sp. induces a significant fall in blood HDL levels when compared to the control level, supporting the extract's hypolipidemic effect [54].…”

Section: Discussionmentioning

confidence: 74%

Antidiabetic Effect of Hexane Extract of Costus Speciosus and Metformin in Rats

Kilany

Soliman

Marie

et al. 2022

Advances in Environmental and Life Sciences

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“…1988; Kalailingam et al . 2013). Among these compounds, the steroidal sapogenins have been reported to lack antifungal activity (Yang et al .…”

Section: Resultsmentioning

confidence: 99%

Antifungal activity of extracts and purified saponins from the rhizomes of Chamaecostus cuspidatus against Candida and Trichophyton species

Cota

Oliveira

Borges

et al. 2020

J. Appl. Microbiol.

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Aim: To evaluate the antifungal activity of extracts of Chamaecostus cuspidatus against Candida and Trichophyton species. Methods and Results: Crude ethanol extracts of leaves, stems and rhizomes were prepared and evaluated for antimicrobial activity. Only the rhizomes extract (RE) showed antifungal activity but had no inhibitory effect against bacteria (Staphylococcus aureus and Escherichia coli). The RE was then submitted to liquid-liquid partition with hexane (Hex), dichloromethane, chloroform, ethyl acetate and water. The Hex fraction (Hex Fr) from the RE was found to have the best antifungal effect. Three known saponins were isolated from the Hex Fr, of which two (dioscin and aferoside A) showed good antifungal activity. In addition, Hex Fr and the two bioactive compounds had no antibacterial effect, but exhibited fungicidal activity, caused significant changes in the morphology of the fungal cells and showed anti-Candida albicans biofilm activity. Finally, the bioactive plant products presented greater selectivity for fungal cells over normal human cells. Conclusions: The rhizomes of C. cuspidatus have bioactive saponins that function as effective antifungals against Candida and Trichophyton species, and have antibiofilm activity against C. albicans. Significance and Impact of the Study: Chamaecostus cuspidatus REs may have potential clinical application towards the management of superficial mycoses caused by Candida and Trichophyton species.

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“…Various bio-components from Costus igneus showing anti-diabetic activities are also mentioned in Table 1. [53][54][55][56][57][58][59][60] RESULT AND DISCUSSION: Diabetes mellitus is possibly the world's fastest-growing metabolic disorder. Appropriate therapies are required to prevent it.…”

Section: Proteinsmentioning

confidence: 99%

Untitled

2019

IJPSR

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Objective: Diabetes mellitus is an interminable metabolic disorder that has highly affected human health and quality of life. Conventional agents are being applied to control this disorder along with lifestyle management. But they are not totally effective and nobody has ever been diagnosed with full recovery of diabetes. Medicinal plants have been used for greater extent for control of diabetes mellitus in various traditional system of medicine worldwide as they are of natural origin and many of them are known to be effective against diabetes. Costus igneus is known as a blazing Costus, step stepping stool or Spiral banner. In India, it is popularly known as insulin plant due to the consumption of leaves of Costus igneus helps to prevent diabetes mellitus by decreasing the blood glucose level. A comprehensive review was conducted to collect data about medicinal herbs used for the treatment of diabetes mellitus. This review deals with the study of chemical structures of plant constituents and their mechanism of action. Materials and Methods: Review is mainly focused on Costus igneus especially on its anti-diabetic activity. Result: Reviews suggest that Costus igneus has anti-diabetic potential especially on diabetes mellitus. Conclusion: Considering the ability of the valuable things present in Costus igneus, this review is aimed to summarize the information of the biochemical constituents, their chemical structures, and mode of action. Due to the high therapeutic potential, these bio-compounds deserve special attention.

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Isolation and quantification of flavonoids from ethanol extract of Costus igneus rhizome (CiREE) and impact of CiREE on hypoglycaemic, electron microscopic studies of pancreas in streptozotocin (STZ)-induced diabetic rats

Cited by 11 publications

References 27 publications

Antidiabetic Effect of Hexane Extract of Costus Speciosus and Metformin in Rats

Antidiabetic Effect of Hexane Extract of Costus Speciosus and Metformin in Rats

Antifungal activity of extracts and purified saponins from the rhizomes of Chamaecostus cuspidatus against Candida and Trichophyton species

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