This paper reports the first demonstration of an isolation effect or von Restorff effect (von Restorff, 1933) in the context of a spatial-memory task: Short-term serial recall was enhanced for both the location and the serial position of one red dot presented amongst a sequence of otherwise black dots. When the serial position of the isolate was fixed, the spatial isolation effect only emerged when participants received a control block of trials before the block of isolation trials (Experiment 1). However, when the serial position of the isolate was varied across isolation trials, an isolation effect was still produced regardless of condition order (Experiment 2). It is suggested that both temporal grouping strategies and greater item-specific processing may have contributed to the enhanced retention of the isolate.When an item differs in some way from the other items in a verbal to-be-remembered sequence, memory for the distinct item is enhanced. This isolation effect or von Restorff effect-as it is also commonly known following its discoverer (von Restorff, 1933)-is a robust phenomenon that has been replicated numerous times in many different methodological settings. Although an isolation effect has been found when an item is postcategorically distinct from its neighbours (e.g., a digit amongst syllables; Fabiani & Donchin, 1995), in most demonstrations the isolate has been precategorically (or perceptually) distinct, in terms of, for example, its colour (e.g., Huang & Hynum, 1970;Rosen, Richardson, & Saltz, 1962) or size (e.g., Huang & Hynum, 1970;Kelley & Nairne, 2001). Such effects in which isolation is implemented through precategorical attributes suggest that the phenomenon is unlikely to be related specifically to verbal Correspondence should be addressed to Katherine Guérard, É cole de psychologie, Université Laval, Québec, G1K 7P4, Canada. E-mail: katherine.guerard.1@ulaval.caThanks are due to Josée Bluteau for assistance in running the experiment. We would also like to thank François Vachon for critical reading of an earlier draft.