Isolation and structural characterization of 2R, 3R taxifolin 3-O-rhamnoside from ethyl acetate extract of Hydnocarpus alpina and its hypoglycemic effect by attenuating hepatic key enzymes of glucose metabolism in streptozotocin-induced diabetic rats

Balamurugan, Ramadass; Vendan, S. Ezhil; Aravinthan, Adithan; Kim, Jong-Hoon

doi:10.1016/j.biochi.2015.02.003

Cited by 22 publications

(17 citation statements)

References 62 publications

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“…Abnormal changes on glucose metabolism, including decreased glycolysis, impeded glycogenesis, and increased gluconeogenesis in diabetic patients, are observed [ 23 ]. Pyruvate kinase couples the free energy of phosphoenolpyruvate hydrolysis for ATP synthesis to form pyruvate [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Studies on the Antidiabetic and Antinephritic Activities ofPaecilomyces hepialiWater Extract in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats

Wang

Teng

Liu

et al. 2016

Journal of Diabetes Research

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Paecilomyces hepiali is a fungus widely used in Asian countries for various potential pharmacological activities. The present study aims to evaluate the antidiabetic and antinephritic effects of the Paecilomyces hepiali mycelium water extract (PHC) in diabetic rat, which is established by eight-week high-fat diet administration followed by one-week tail intravenous injection of 25 mg/kg streptozotocin (STZ). After four-week 0.12 g/kg metformin and PHC at doses of 0.08, 0.4, and 2.0 g/kg treatment, an increment of body weight, a decrement of plasma glucose, low levels of total cholesterol, and low density lipoprotein cholesterol in diabetic rats were observed. PHC promotes glucose metabolism by enhancing insulin, pyruvate kinase activity, and increasing the synthesis of glycogen. PHC normalized the disturbed levels of superoxide dismutase, methane dicarboxylic aldehyde, and glutathione peroxidase in kidney. The inhibitory effects on the levels of interleukin-2, interleukin-6, interleukin-10, and tumor necrosis factor-α in serum and kidney revealed the protection of PHC against diabetic nephropathy. Compared with nontreated diabetic rats, four-week PHC treatment resulted in a decrement on nuclear factor kappa B expression in kidney. These results show that Paecilomyces hepiali possesses antidiabetic and antinephritic effects which are related to the modulation of nuclear factor kappa B activity.

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Section: Discussionmentioning

confidence: 99%

Studies on the Antidiabetic and Antinephritic Activities ofPaecilomyces hepialiWater Extract in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats

Wang

Teng

Liu

et al. 2016

Journal of Diabetes Research

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“…isolated an flavanone: 2R, 3R taxifolin 3-O-rhamnosid, and tested its action as insulin secretagogue, which showed action through closure of K ATP channels and the opening of cell surface Ca 2+ channels signaling pathway. [ 46 ] This mechanism is similar to the mechanism of sulfonylureas. [ 123 ] Thus, further studies are needed to confirm effective and low side effects that sulfonylureas to be a more effective alternative.…”

Section: Discussionmentioning

confidence: 72%

Influence of flavonoids on mechanism of modulation of insulin secretion

Soares¹,

Leal²,

Silva³

et al. 2017

Phcog Mag

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Background:The development of alternatives for insulin secretion control in vivo or in vitro represents an important aspect to be investigated. In this direction, natural products have been progressively explored with this aim. In particular, flavonoids are potential candidates to act as insulin secretagogue.Objective:To study the influence of flavonoid on overall modulation mechanisms of insulin secretion.Methods:The research was conducted in the following databases and platforms: PubMed, Scopus, ISI Web of Knowledge, SciELO, LILACS, and ScienceDirect, and the MeSH terms used for the search were flavonoids, flavones, islets of Langerhans, and insulin-secreting cells.Results:Twelve articles were included and represent the basis of discussion on mechanisms of insulin secretion of flavonoids. Papers in ISI Web of Knowledge were in number of 1, Scopus 44, PubMed 264, ScienceDirect 511, and no papers from LILACS and SciELO databases.Conclusion:According to the literature, the majority of flavonoid subclasses can modulate insulin secretion through several pathways, in an indication that corresponding molecule is a potential candidate for active materials to be applied in the treatment of diabetes.SUMMARY The action of natural products on insulin secretion represents an important investigation topic due to their importance in the diabetes controlIn addition to their typical antioxidant properties, flavonoids contribute to the insulin secretionThe modulation of insulin secretion is induced by flavonoids according to different mechanisms. Abbreviations used: KATP channels: ATP-sensitive K+ channels, GLUT4: Glucose transporter 4, ERK1/2: Extracellular signal-regulated protein kinases 1 and 2, L-VDCCs: L-type voltage-dependent Ca+2 channels, GLUT1: Glucose transporter 1, AMPK: Adenosine monophosphate-activated protein kinase, PTP1B: Protein tyrosine phosphatase 1B, GLUT2: Glucose transporter 2, cAMP: Cyclic adenosine monophosphate, PKA: Protein kinase A, PTK: Protein tyrosine kinase, CaMK II: Ca2+/calmodulin-dependent protein kinase II, GSIS: Glucose-stimulated insulin secretion, Insig-1: Insulin-induced gene 1, IRS-2: Insulin receptor substrate 2, PDX-1: Pancreatic and duodenal homeobox 1, SREBP-1c: Sterol regulatory element binding protein-1c, DMC: Dihydroxy-6’-methoxy-3’,5’-dimethylchalcone, GLP-1: Glucagon-like peptide-1, GLP-1R: Glucagon-like peptide 1 receptor.

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“…[49][50][51][52][53] The marked beneficial role of taxifolin, cryptolepine and reserpine in inhibiting activities of carbohydrate metabolizing enzymes and preserving β-cell function through oxidative stress obliteration have also been documented. [54][55][56] Furthermore, while the improved hemostatic imbalance and glycemic control, attenuated lipid peroxidation and ameliorated inflammatory and oxidative stress in diabetic animals have been linked with antidiabetic attributes of luteolin, gingerol and ursolate, 49,53,57 berberine and kaempferol have been opined to elicit antidiabetic influence of P. suberosa elicited marked hypoglycemic potential in STZ-challenged diabetic animals. The data also divulged the beneficial attributes of the extract in boosting antioxidant defense systems and improving the lipid metabolism imbalance experienced during diabetes.…”

Section: Discussionmentioning

confidence: 99%

Pteleopsis suberosa Engl. and Diels (Combretaceae) aqueous stem bark extract extenuates oxidative damage in streptozotocin-induced diabetic Wistar rats

Raliat¹,

Sabiu²,

Abdulhakeem³

2019

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Pteleopsis suberosa Engl. and Diels (Combretaceae) is a deciduous shrub, 6-10 m tall with characteristic bark distinctively covered with corky warts. It occurs freely in West Africa, from Senegal east to Nigeria. The different parts of P. suberosa (PS) have been medicinally used throughout West Africa. A decoction of the fresh roots is normally applied as enema, purgative, antidysentery and to treat dermatitis, stomach ache and gastric ulcers. 1 Its roots and young shoots extracts are taken as antituisive. The bark or leafy twig infusion of PS is also ethnomedicinally valued to treat jaundice, toothache, haemorrhoids, filariasis, wounds, conjunctivitis, trachoma, cataract and as aphrodisiac. 2,3 It has also been reported to be rich in triterpenoids, coumarins and tannins as its essential phytonutrients. 4Pteleopsis suberosa Engl. and Diels (Combretaceae) aqueous stem bark extract extenuates oxidative damage in streptozotocin-induced diabetic Wistar rats ABSTRACT Context: Pteleopsis suberosa Engl. and Diels (Combretaceae) is an ethnomedicinally valued deciduous shrub with significant therapeutic application against diabetes in West Africa. Aims: This study evaluated the hypoglycaemic and antioxidant activity of its aqueous stem bark extract (PSAE) over a 15-day experimental period in streptozotocin (STZ)-challenged diabetic rats. Methods and Material: STZ-induced diabetic rats were administered 50, 100 and 200 mg/kg body weight of the extract once daily and the blood glucose levels were monitored for 15 days. The bioactive constituents of PSAE were analyzed using Gas Chromatography-Mass Spectrometry (GC-MS) technique. Results: Treatment with PSAE markedly (p< 0.05) ameliorated the concentrations of blood glucose and improved the lipid metabolism imbalance in the diabetic animals. Also, while PSAE significantly (p<0.05) improved glycogen and glutathione (reduced) levels as well as glucose-6-phosphate dehydrogenase, superoxide dismutase and catalase activities, the concentrations of glucose and malondialdehyde coupled with the activity of α-amylase were significantly reduced in the liver of PSAE-administered diabetic animals when compared with those of the normal control and untreated diabetic groups. The observed improvements could be associated with the phytoconstituents of PSAE as evident from the results of the GC-MS analysis. Put together, the elicited effects compared favorably well with metformin (a standard hypoglycemic drug) and are suggestive of antidiabetic and antioxidant capabilities of the extract. Conclusion: The scope of the data presented in this study indicates that the extract ameliorated streptozotocin-induced diabetes in rats and it is suggested to be mediated via antioxidant and concerted blood glucose lowering actions.

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Isolation and structural characterization of 2R, 3R taxifolin 3-O-rhamnoside from ethyl acetate extract of Hydnocarpus alpina and its hypoglycemic effect by attenuating hepatic key enzymes of glucose metabolism in streptozotocin-induced diabetic rats

Cited by 22 publications

References 62 publications

Studies on the Antidiabetic and Antinephritic Activities ofPaecilomyces hepialiWater Extract in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats

Studies on the Antidiabetic and Antinephritic Activities ofPaecilomyces hepialiWater Extract in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats

Influence of flavonoids on mechanism of modulation of insulin secretion

Pteleopsis suberosa Engl. and Diels (Combretaceae) aqueous stem bark extract extenuates oxidative damage in streptozotocin-induced diabetic Wistar rats

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