Isolation and synthesis of a new clerodane from Echinodorus grandiflorus

Costa, Marta; Tanaka, Clara M. A.; Imamura, Paulo M.; Marsaioli, Anita J.

doi:10.1016/s0031-9422(98)00464-6

Cited by 42 publications

(29 citation statements)

References 7 publications

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“…A strong IR absorption band occurred at 3434 cm -1 . The molecular formula, C 21 H 30 O 5 (HRESIMS), was consistent with this proposal. One of the hydroxyl groups was again located at C-1, showing the same couplings as in 7.…”

supporting

confidence: 85%

Divinatorins A−C, New Neoclerodane Diterpenoids from the Controlled Sage Salvia divinorum

et al. 2003

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supporting

confidence: 85%

Divinatorins A−C, New Neoclerodane Diterpenoids from the Controlled Sage Salvia divinorum

et al. 2003

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“…Substâncias terpenoídicas das quais destacamse diterpenos dos tipos clerodano (Costa et al, 1999;Tanaka, 2000) e cembrano tais como equinodol (Manns;Hartman, 1993) e ácido equinóico (Tanaka et al, 1997, Tanaka, 2000 foram isoladas de E. grandifl orus. Os diterpenos equinofi linas A e B (Kobayashi et al, 2000) e equinodolidos A e B (Shigemori et al, 2002) foram identifi cados em E. macrophyllus.…”

Section: Introductionunclassified

Investigação das atividades analgésica e antiinflamatória do extrato metanólico dos rizomas de Echinodorus grandiflorus

Dutra¹,

Tavares²,

Ferraz³

et al. 2006

Rev. bras. farmacogn.

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RESUMO:O presente trabalho investigou as atividades analgésica e antiinfl amatória do extrato metanólico de rizomas de Echinodorus grandifl orus. Para isto, foram realizados os testes de contorções abdominais induzidas por ácido acético; tempo da lambida da pata induzida por formalina; edema de pata e pleurisia induzidas por carragenina. As doses de 100, 200 e 400 mg/kg inibiram as contorções em 34,30%, 35,84% e 36,07%, respectivamente. O tempo de lambida da primeira fase foi reduzido nas doses de 200 e 400 mg/kg, enquanto a segunda fase teve redução em 400 mg/kg. As doses testadas diminuíram o edema, enquanto o volume do exsudato foi reduzido em 24,61% na dose de 400 mg/kg. As doses de 200 e 400 mg/kg diminuíram a migração leucocitária. Os resultados indicam que o extrato de E. grandifl orus testado pode constituir alvo potencial para uso em terapias da dor e da infl amação. Unitermos:Echinodorus grandifl orus, atividade analgésica, atividade antiinfl amatória.ABSTRACT: "Investigation of analgesic and anti-infl ammatory activities of Echinodorus grandifl orus rhizomes methanol extract". The present work investigated the analgesic and antiinfl ammatory activities of the methanol extract of the rhizomes of Echinodorus grandifl orus. For this purpose, acetic acid writhing, paw licking induced by formalin, carrageenan-induced rat paw edema and pleurisy tests were performed. The doses of 100, 200 and 400 mg/kg inhibited the contortions 34.30%, 35.84% and 36.07%, respectively. The lick of the paw 1st phase was reduced at the doses of 200 and 400 mg/kg, while the 2nd phase had reduction at 400 mg/kg. All doses inhibited the paw edema, while the volume of the exsudate was reduced 24.61% in the dose of 400 mg/kg. The doses of 200 and 400 mg/kg decreased the leukocytes migration. The results indicate that the methanol extract of E. grandifl orus can constitute target potential for use in therapies of the pain and infl ammation.

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“…The pro-19S diastereotopic proton, which was ω-coupled ( 4 J = 2.0 Hz) with H-6β, 23 showed correlations with H-1α and H 3 -20, indicating α-and axial orientation for both C-20 and C-19. In addition, the axially 24 except that a methoxy group was evident in 6. HMBC correlation in 6 from the methoxy protons (δ H 3.57) to C-16 verified that the methoxy group was at C-16.…”

Section: Resultsmentioning

confidence: 99%