2020
DOI: 10.9734/csji/2019/v28i430149
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Isolation, Bioactivity and Charaterisation of 3-Ethynyl-5-(2,3-dehydropyrrole) Pyridine from the Stem Bark of Adenanthera pavonina

Abstract: Natural products from medicinal plants either as pure compounds or standardized extracts, provide unlimited opportunities for new drug leads, because of the unmatched availability of chemical diversity. Due to an increasing demand for therapeutic drugs from natural products, interest particularly in edible plants has grown throughout the world. The phytochemical screening was carried out via standard procedures while the isolation and characterization was done using different solvents via thin layer and column… Show more

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“…In addition, the alcoholic extract of the leaves of A. pavonina showed the presence of an alkaloidal substance, melting point 88 0 C [12]. Later on, 3ethynyl, 5(2, 3-dehydropyrrole) pyridine (49) was isolated from the stem bark of the ethyl acetate fraction of ethanol extract [33].…”
Section: Alkaloidmentioning
confidence: 99%
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“…In addition, the alcoholic extract of the leaves of A. pavonina showed the presence of an alkaloidal substance, melting point 88 0 C [12]. Later on, 3ethynyl, 5(2, 3-dehydropyrrole) pyridine (49) was isolated from the stem bark of the ethyl acetate fraction of ethanol extract [33].…”
Section: Alkaloidmentioning
confidence: 99%
“…-glucopyranosyl-(6' 2' -2) --D-glucopyranosyl(6'' 1', 2 2)--D-glucopyranoside (71) , a few compounds showed potential pharmacological effects.β-sitosterol glucoside (4) was isolated from the leaves of A. pavonina and showed potential antioxidant and hepatoprotection ability against CCl4 induced liver injury rats[38]. In the investigation of antioxidant and (49) showed potential activity against Gram-positive and Gram-negative bacteria as well as radical scavenging power[33]. In the case of cytotoxic activity, quercetin 3-O-αdirhamnopyranosyl-(1′′′→2′′,1′′′′→6′′)-β-glucopyr-anoside-4′-methoxy (29) reported the moderate activity on MCF7 and HepG2 cell lines that was isolated from the leaves[32] As the anti-inflammatory potentials, tamarixetin 3-O-(α-ʟ-rhamnopyranosyl)-(1→2)-β-ᴅgalactopyranoside (43) was the most effective at suppressing TNF-a protein and m-RNA levels followed by isovitixin (25), quercetin-3-O-[α-ʟrhamnopyranosyl-(1→2)]-[α-ʟ-rhamnopyranosyl-(1→6)]-β-ᴅ-galactopyrano-side (42) and quercetin 3-O-(α-ʟ-rhamnopyranosyl-(1→2)-β-ᴅ-xylopyranoside (41) as TNF-a inhibitors in LPS-stimulated BV2 cells.…”
mentioning
confidence: 99%